Association of collagenous colitis with prurigo nodularis

Abstract

The etiology and pathogenesis of collagenous colitis (CC) is poorly understood and probably multifactorial; many potential pathophysiological mechanisms have been described, although none have been conclusively proved. Circumstantial evidence suggests that CC appears as an autoimmune response to a luminal or epithelial antigen of unknown origin. Infections and certain drugs (e.g. NSAID, lansoprazole) may act as triggers for an immune-mediated process. CC is characterized clinically by chronic watery, nonbloody diarrhea with normal endoscopic appearance and without radiological abnormalities, but specific microscopic changes in the colon. Histopathology is featured by the presence of a thickened subepithelial collagen band adjacent to the basal membrane. Up to 40% of patients with CC have associated diseases of autoimmune or inflammatory origin, such as thyroid disease, coeliac disease, rheumatoid arthritis, diabetes mellitus, Sjögren's syndrome, CREST syndrome, scleroderma, pernicious anemia, and sarcoidosis. Prurigo nodularis is a chronic condition characterized by intensely pruritic, lichenified, or excoriated papules and nodules of unknown etiology. It is assumed to represent a cutaneous reaction pattern to repeated scrubbing or scratching caused by pruritus. We report a case of CC and prurigo nodularis. To our knowledge, this association has not been reported earlier.

Association between Prurigo Nodularis and Etiologies of Peripheral Neuropathy: Suggesting a Role for Neural Dysregulation in Pathogenesis

“…It is associated with other dermatologic conditions, such as atopic dermatitis and other systemic diseases [2]. Examples of systemic diseases associated with PN include liver or kidney dysfunction, hyperthyroidism, metabolic dysfunction, inflammatory processes, psychological factors, and malignancy [3][4][5]. The underlying mechanism of how these conditions contribute to the pathogenesis of PN remains unclear; however, neural dysregulation is thought to play a central role.…”

Sustained Release Myofascial Release as Treatment for a Patient with Complications of Rheumatoid Arthritis and Collagenous Colitis: A Case Report

“…(10) It is also suggested that IBD may share pathogenic pathways with other autoimmune diseases; (1,8,11) 40% of individuals with collagenous colitis also have autoimmune diseases such as RA. (12,13) Extraintestinal signs and symptoms signifying coexistent IBD and autoimmune diseases include chronic fatigue, fever, night sweats, skin lesions, uveitis, arthritis, migratory arthralgias, and hip pain. (1,10) IBD displays periods of exacerbation and remission.…”