Association of common variants on chromosome 8q24 with gastric cancer in Venezuelan patients

Labrador, Luis; Torres, Keila E.; Camargo, María; Santiago, Laskhmi; Valderrama, Elvis; Chiurillo, Miguel Ángel

doi:10.1016/j.gene.2015.04.081

Cited by 11 publications

(8 citation statements)

References 35 publications

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“…Mutations in the CYP1A1 , GSTM1 , MTHFR , SRD5A2 , AR , and GSTA1 genes were relevant in prostate cancer in Latin Americans [108,109,110,111,112], also determined in Caucasians and Asians [113,114,115,116,117,118,119,120,121]. The IL-1 , TP53 , WNT , 8q24 region and IL-8 genes were consistent with gastric cancer in Latin Americans [122,123,124,125,126], as well as in some Asians and Caucasians [127,128,129,130]. The CDKN2A and MC1R genes were related with myeloma in Latin Americans [131], as well as in Caucasians [132,133].…”

Section: Germline Cancer Predisposition In Latin Americamentioning

confidence: 99%

State of Art of Cancer Pharmacogenomics in Latin American Populations

López‐Cortés

Guerrero

Redal

et al. 2017

IJMS

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Over the past decades, several studies have shown that tumor-related somatic and germline alterations predicts tumor prognosis, drug response and toxicity. Latin American populations present a vast geno-phenotypic diversity due to the great interethnic and interracial mixing. This genetic flow leads to the appearance of complex characteristics that allow individuals to adapt to endemic environments, such as high altitude or extreme tropical weather. These genetic changes, most of them subtle and unexplored, could establish a mutational profile to develop new pharmacogenomic therapies specific for Latin American populations. In this review, we present the current status of research on somatic and germline alterations in Latin America compared to those found in Caucasian and Asian populations.

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Section: Germline Cancer Predisposition In Latin Americamentioning

confidence: 99%

State of Art of Cancer Pharmacogenomics in Latin American Populations

López‐Cortés

Guerrero

Redal

et al. 2017

IJMS

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“…A manual search of references cited in the eligible articles did not reveal any additional studies. Consequently, seven articles including ten case-control studies met our inclusion criteria, of these six studies investigated rs6983267 polymorphisms and GC susceptibility had a total of 4,813 subjects [ 12 , 13 , 15 – 18 ] and four studies investigated rs1447295 variants in 2,054 subjects [ 14 , 16 – 18 ]. Detailed characteristics and genotype distribution of eligible studies are summarized in Tables 1 and 2 , respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Over the last two decades, a number of molecular epidemiological studies have investigated the link between two polymorphisms, rs6983267 and rs1447295, in this region and analysis of association to GC susceptibility have revealed inconsistent results. Several studies suggest that the rs6983267 polymorphism is associated with an increased risk of GC [ 12 , 13 ], while an inverse association was seen with rs1447295 polymorphisms [ 14 ]; however other studies have failed to confirm such associations [ 15 – 18 ]. Taking into account all of these controversial results, we executed the first meta-analysis study to evaluate the existence of any association between polymorphism variants on the 8q24 chromosome (specifically rs6983267 and rs1447295) and GC susceptibility.…”

Section: Introductionmentioning

confidence: 99%

Genetic variations at 8q24 and gastric cancer susceptibility: A meta-analysis study

2017

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BackgroundPublished data on the association between genetic variants on the 8q24 chromosome and gastric cancer (GC) susceptibility are inconclusive. Here we present a meta-analysis designed to evaluate the relationship between 8q24 variants (single nucleotide polymorphisms (SNPs) labeled rs6983267 and rs1447295) and risk of developing GC.MethodsA literature search was performed using studies published on PubMed, Science Direct, OVID and Web of Science databases up to December 2016. Studies were selected based on our enrollment criteria, relevant data was extracted from each study and the odds ratios (OR), and 95% confidence intervals (CI) were calculated and used to assess the strength of associations found between 8q24 polymorphisms and GC risk. Conclusions about acceptable strong associations were made after taking into account sample heterogeneity and sensitivity analyses.ResultsA total of seven studies containing ten case-control studies were selected. Among these studies were six studies of 1,421 GC patients and 3,393 controls examining the role of the rs6983267 SNP and four studies including 779 cases and 1,266 controls examining rs1447295 SNP. The pooled results of these studies indicated that there was no significant association between both genetic variants and GC susceptibility using an allele, dominant, recessive and homozygote genetic models. When using a heterozygote genetic model, a significant increase was found in the association of GC risk for rs6983267 SNP (OR = 1.07, 95% CI = 1.01–1.12, P = 0.015), whereas for rs1447295 SNP a significant decreased risk was detected (OR = 0.82, 95% CI = 0.69–0.98, P = 0.030). In subgroup analyses based on ethnicity and genotyping methods, similar non-significant results were observed for the rs1447295 variant using the four genetic models (allele, dominant, recessive or homozygote models) and for the rs6983267 variant using only the allele, recessive and homozygote models. However, after a multiple testing correction to our calculations, these associations remained non-significant.ConclusionMeta-analysis of gastrointestinal cancer genetic analysis studies did not confirm an association between 8q24 chromosome polymorphisms (specifically rs6983267 and rs1447295) and susceptibility to GC in the general populations.

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“…Analysis of a gastric cancer GWAS dataset indicated the presence of susceptibility loci associated with different pathways in cancer progression [89]. Chromosome locus 8q24 was reported to be associated with different cancers including gastric cancer [55], and SNP rs4733616 was specifically associated with gastric cancer. Gastric cancer GWAS facilitated the identification of two tumor subtypes -gastric cardia and gastric noncardia -in a population study [101].…”

Section: • Gastric Cancermentioning

confidence: 99%

“…Genome-wide methylation [52]; the major genes affected were PTK2, RND1, and UBL3 which regulate recurrence of cancer [52] Sensitive locus for mutations 4q21 [22] 4q21 [22] SNP rs1229984 in ADH1B [22] SNP rs7922612 related with survival [22] Germline copy number loss of UGT28 and gain of PLEC [53] Gastric cancer FAT4, a novel tumor suppressor identified by exome sequencing gets inactivated due to hypermethylation (field canerization) [54] Epigenetic silencing of GLDC [57] Susceptibility locus 8q24 [55] 8q24.3 [58] SNP rs4733616 [55] SNP rs2294008 was associated with decreased risk of duodenal cancer [55] SNP rs2294008 was found to be associated with increased risk of gastric cancer and decreased risk of duodenal cancer [58] SNP rs2976392 [22] Loss of CNV at 5q22 region surrounding APC [56] Hepatocellular carcinoma (liver cancer)…”

Section: Cervical Cancermentioning

confidence: 99%

Genome-Wide Association Studies and Epigenome-Wide Association Studies Go Together in Cancer Control

Verma

2016

Future Oncol.

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Completion of the human genome a decade ago laid the foundation for: using genetic information in assessing risk to identify individuals and populations that are likely to develop cancer, and designing treatments based on a person's genetic profiling (precision medicine). Genome-wide association studies (GWAS) completed during the past few years have identified risk-associated single nucleotide polymorphisms that can be used as screening tools in epidemiologic studies of a variety of tumor types. This led to the conduct of epigenome-wide association studies (EWAS). This article discusses the current status, challenges and research opportunities in GWAS and EWAS. Information gained from GWAS and EWAS has potential applications in cancer control and treatment.

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Association of common variants on chromosome 8q24 with gastric cancer in Venezuelan patients

Cited by 11 publications

References 35 publications

State of Art of Cancer Pharmacogenomics in Latin American Populations

State of Art of Cancer Pharmacogenomics in Latin American Populations

Genetic variations at 8q24 and gastric cancer susceptibility: A meta-analysis study

Genome-Wide Association Studies and Epigenome-Wide Association Studies Go Together in Cancer Control

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