Association of common variations of the E-cadherin with endometriosis

Abstract

Endometriosis is a polygenic and multifactorial disease. E-cadherin (CDH1) gene encodes an epithelial cell-cell adhesion glycoprotein that modulates a wide variety of processes, including cell polarization, migration and cancer metastasis. Decreased expression of CDH1 in epithelial cells in peritoneal endometriosis has been reported in advanced stages of endometriotic lesions. We investigated the CDH1 -160C/A and +54C/T variations with susceptibility to endometriosis in an Iranian population. In this case-control study, 149 patients with endometriosis (stages I-IV) and 151 healthy women as controls were included. Genotyping was performed using PCR-RFLP method. A p value of <0.05 was considered statistically significant. The CDH1 + 54TT genotype was significantly lower (p = 0.012; OR = 0.30, 95% CI: 0.12-0.77) in the patients (11.6%) than the control group (26.7%). The CDH1 + 54T allele was significantly lower (p = 0.001; OR = 0.55, 95% CI: 0.38-0.77) in the cases (35.7%) compared with the control group (50.3%). No association was found between CDH1 - 160C/A polymorphism and endometriosis. The CDH1 +54C/T was associated with susceptibility to endometriosis in Iranian population, and +54T allele may have a protective role in progression of endometriosis.

Hypoxia‑induced lactate dehydrogenase A protects cells from apoptosis in endometriosis

“…Increased expression of E-cadherin, a calcium-dependent adhesion molecule found on the surface of epithelial cells, may enhance the connection between cells, thus inhibiting their migratory and invasive abilities ( 49 ). Downregulated expression of E-cadherin has been reported to be potentially associated with susceptibility to endometriosis, resulting in elevated migration and invasion potentials of endometriotic cells ( 50 ). β-catenin protein localizes in the cell membrane and cytoplasm, where it is mainly involved in cell proliferation, differentiation and apoptosis ( 51 ).…”