Association of congenital microtia with environmental risk factors in South Korea

Lee, Kyeong Tae; Yang, Eun‐Jung; Lim, So-Young; Pyon, Jai‐Kyong; Mun, Goo‐Hyun; Bang, Sa Ik; Oh, Kap Sung

doi:10.1016/j.ijporl.2011.12.009

Cited by 22 publications

(11 citation statements)

References 28 publications

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“…After analyzing the epidemiologic characteristics of congenital microtia with our study, the results were found to be consistent with those of prior studies from different populations such as the United States [9], Korea [6], Japan [10] and Europe [11]. In this study, a stronger male predominance (69.7%) was observed compared with those in prior studies, including a 54.0% male predominance in 354 Hungary patients [12] and 56.7% in 742 Texan patients [13] in the United States.…”

Section: Discussionsupporting

confidence: 87%

Phenotypic characterization and risk factors for microtia in East China, a case–control study

Chen

Jin

et al. 2014

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionsupporting

confidence: 87%

Phenotypic characterization and risk factors for microtia in East China, a case–control study

Chen

Jin

et al. 2014

International Journal of Pediatric Otorhinolaryngology

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“…Several possibilities for the cause is suggested but still poorly understood. These include vertebrae abnormalities [8], medications [9,10], genetic disorders [11], and even illness during pregnancy [12]. There are two forms of microtia, unilateral or bilateral.…”

Section: Pathologymentioning

confidence: 99%

A bioprinting printing approach to regenerate cartilage for microtia treatment

et al. 2018

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The need to search for biomaterials that can promote tissue regeneration and easy to replicate and manufacture is a major driving force for research and development in the area of reconstructive surgery and regenerative medicine. It is of great importance to otolaryngologists to find alternate solutions that require harvesting large amounts of autologous cartilage in patients needing cartilage grafts. Due to its very limited self-regeneration capacity, cartilage repair and reconstruction is extremely challenging. Microtia is a congenital condition of abnormal development of the outer and/ or the middle ear and can range from mild to complete absence of the ear. Current treatment methods such as autologous, alloplastic and prosthetic reconstruction have limitations such as donor site morbidity, long-term complications and implant failure. 3D printing is an exciting solution to address the challenges of microtia and create customised implants. The ability to deposit cells and biomaterials in a controlled and precise manner, allows the fabrication of implants with complex internal architecture and functional properties not achievable through traditional manufacturing methods. Despite the ability to mimic native properties and structure of tissue, 3D printed constructs using pristine inks lack the structural integrity and adequate mechanical properties for use in vivo or handling. These requirements highlight the importance of ink development and selection, which is a continuing challenge in the bioprinting process. This review will address the current treatment options for patients with microtia and the potential of 3D bioprinting in area of auricular cartilage regeneration. In particular, the use of hybrid printing to better mimic the practical and functional requirements of an ear scaffold will be discussed.

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“…In addition, growth restriction, preterm delivery, mother's age and weight during pregnancy and parental consanguinity are also associated with birth defects [7,8]. Furthermore, it has been reported that there is an association between environmental exposures such as air pollution, alcohol consumption, environmental tobacco smoking, radiation, pesticides and pregnancy outcomes such as pregnancy loss, stillbirth, fetal growth, preterm birth and congenital anomalies [9][10][11]. There have been no studies on the risk factors associated with birth defects in Sulaimani; therefore, the current study was undertaken to determine the risk factors associated with congenital anomalies in the governorate.…”

Section: Introductionmentioning

confidence: 99%

A Case-Control Study for Assessing Risk Factors for Congenital Anomalies among Children in Sulaimani City

2018

KJAR

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Congenital anomalies comprise a wide range of abnormalities in body structure or function that are present at birth and are of prenatal origin. These are defined as structural changes that have significant medical, social or cosmetic consequences for the affected individual, and typically require medical intervention. According to our Knowledge, research is scarce on these conditions in Sulaimaniyah city. Therefore, the current study was conducted to investigate potential risk factors for congenital anomalies. A case-control study was carried out from March to August 2017 involving 400 children (200 cases and 200 controls) aged 0-5 years. Required data were obtained on the risk factors through face to face interviews with mothers of cases and controls. The data were using descriptive statistical methods, Chi-square and Logistic Regression using STATA 11, calculating odds ratios and condensing P value less than 0.05 as statistically significant. The mean age of the children was 1.9 years and age of their mothers at the time of pregnancy was 28 years. Congenital heart anomalies were the commonest type accounting for 27.5%. Significant risk factors for congenital anomalies were family history (OR=2.24, P= 0.007), maternal obesity (OR= 2.26, P= 0.001), mothers age over 30 (OR=2.78, P= 0.002) and mothers not using folic acid during pregnancy (OR=2.12, P= 0.0007). In general, in order to control and prevent the cases of CM, it is important to provide health education and policies to reduce environmental and maternal risk factors. Further, studies with larger sample size are needed to investigate incidence and risk factors of congenital anomalies.

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Association of congenital microtia with environmental risk factors in South Korea

Cited by 22 publications

References 28 publications

Phenotypic characterization and risk factors for microtia in East China, a case–control study

Phenotypic characterization and risk factors for microtia in East China, a case–control study

A bioprinting printing approach to regenerate cartilage for microtia treatment

A Case-Control Study for Assessing Risk Factors for Congenital Anomalies among Children in Sulaimani City

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