Association of cord blood and maternal lipid profile

Zohra, Noor Fathima S.; Prabhu, Anitha S.; Rao, Smitha B.; Saldanha, Prema

doi:10.18203/2349-3291.ijcp20200211

Cited by 1 publication

(3 citation statements)

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“…The high TGL in these studies has been partly attributed to a high prevalence of vitamin D deficiency (9,10). The values of HDL and LDL in our study were like the reported values by other studies (5,16). The characteristics of the child including sex, BMI, head circumference does not seem to influence the cord blood lipid profile.…”

Section: Discussionsupporting

confidence: 89%

“…In our study the mean TC was 73.31mg%, like those reported by other studies from India (5,14) (8), higher TGL levels were reported in Iranian newborns (9,10). The high TGL in these studies has been partly attributed to a high prevalence of vitamin D deficiency (9,10).…”

Section: Discussionsupporting

confidence: 85%

“…he pathogenesis of atherosclerosis has been described to begin early in life if the newborns have a high lipid concentration in the blood (1). Additionally, it is observed that babies who are born pre-term may have an increased risk of developing coronary artery disease later in their life (2)(3)(4)(5). In general population, the serum levels of total cholesterol (TC), triglycerides (TGL) and its subtypes-LDL (Low-density lipoprotein) and HDL (high density lipoprotein) have been widely studied and documented.…”

Section: Introductionmentioning

confidence: 99%

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Umbilical cord serum lipid profile of healthy neonates- A single center study from rural Tamil Nadu, India

A.G.¹,

Meenakshi²,

Porchelvan³

et al. 2022

Biomedicine

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Introduction and Aim: Umbilical cord lipid profile of neonates might help facilitate the assessment of risk of developing atherosclerotic disorders later in life. This study prospectively measures the cord blood lipid profile of healthy newborn at birth in medical college hospital in rural Tamil Nadu. Material sand Methods: Consecutive full-term newborns (n=105) were enrolled for this study. Umbilical cord blood sample was collected from placental end of the cord immediately after delivery of placenta of each baby and sent to the lab for lipid profile estimation. Results: In the newborns born to non-diabetic mothers, the mean cord blood total serum cholesterol (TC) was 73.31mg %, triglyceride (TGL) was 51.50mg %, high-density lipoproteins (HDL) 24.62 mg % and low-density lipoproteins (LDL) 51.73 mg %. Amongst newborns born to diabetic mothers, the mean TC was 113 mg % (P = 0.001), TGL 98.08mg% (P = 0.045) HDL 28.75 mg% (P = 0.130) LDL 73.48mg% (P = 0.007). Umbilical cord blood lipid profile did not show any significant sex-dependent difference. There was no statistical difference in lipid values between appropriate for gestational age (AGA)and small for gestational age (SGA). Birth weight had a negative correlation to cord blood serum TC and TGL values and showed no correlation to HDL and LDL values. Other parameters including head circumference, length of newborn at birth also showed no correlation to lipid profile. Total cholesterol, TGL and LDL were significantly elevated in newborns born to diabetic mothers. There was no statistical difference in cord blood lipid profile of babies born to mothers who were hypertensive. Conclusion: Infants born to diabetic mothers tend to have significantly elevated lipid values at birth and must be followed regularly later in life to diagnose and treat dyslipidemia and diabetes, to prevent onset of premature atherosclerotic coronary artery disease in this population.

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Section: Discussionsupporting

confidence: 89%