Association of cord blood des-acyl ghrelin with Apgar score and anthropometric measures in relation to its maternal one.

Abdelhamid, Enas R.; Kamhawy, Alyaa H.; Ahmed, Hanaa H.; Shady, Mones M. Abu; Fathy, Ahmed; Fahmy, Reham F.

doi:10.13005/bpj/1743

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…The diabetic children age ranged between 5 and 15 years were divided into two groups: 34 overweight and obese diabetics (Group 1) and nonobese diabetics (Group 2). All anthropometric parameters have been obtained using standardized equipment and following the recommendations of the International Biological Program [20]. Obesity was considered when BMI exceeded 95 th percentile while overweight was considered when BMI was from 85…”

Section: Methodsmentioning

confidence: 99%

Role of Inflammatory Cytokines in Obese and Nonobese Diabetic Children

Abdelhamid

Kamhawy

Ahmed

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Obesity is an expanded health problem worldwide and it is blamed for a startling rise in type 1 diabetes (T1DM), the interaction between obesity, autoimmune processes, and glucose homeostasis is a growing field of study. AIM: This study was undertaken to predict the role of the inflammatory cytokines (interleukin [IL]-17 and IL-10) as biomarkers in early screening for obesity and T1DM and to determine the relation of inflammatory cytokines with diabetic complications especially nephropathy. SUBJECTS AND METHODS: The target group consisted of 92 children with type 1 diabetes children who were diagnosed according to the criteria provided by American Diabetes Association Diabetic; cases were divided into two groups, Group 1 (overweight and obese diabetics) and Group 2 (normal weight diabetic children). The levels of serum IL-17 and IL-10 were assayed in these children by an enzyme-linked immunosorbent assay. Serum triglycerides (TG) and cholesterol levels were measured as well as urinary microalbumin level was estimated for detection of nephropathy. RESULTS: Diabetic overweight and obese children exhibited significantly 3.8 folds more at risk to be bad glycemic control than diabetic children with normal body mass index (BMI). Furthermore, overweight and obese diabetic children displayed significantly 15 times more at risk of having nephropathy than diabetic children with normal BMI. Low serum level of IL 10 and high level of IL 17 showed a significant association with high BMI in diabetic children. High HBA1c, low IL 10, and long disease duration were significantly considered as predominant risk factors for diabetic nephropathy in diabetic children. CONCLUSION: The obtained data from these investigations proved that overweight and obese children have a low serum level of IL-10 and high serum IL-17 levels. The relationship between IL-10/IL-17 can be applied as a good marker for the inflammatory state and these inflammatory interleukins can be employed as biomarkers in early screening for obesity and T1DM. Furthermore, these interleukins can be utilized as a predictor for early diabetic complications, particularly nephropathy.

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Section: Methodsmentioning

confidence: 99%

Role of Inflammatory Cytokines in Obese and Nonobese Diabetic Children

Abdelhamid

Kamhawy

Ahmed

et al. 2020

Open Access Maced J Med Sci

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“…Ghrelin and obestatin are appetite regulatory hormones, originated from the same ghrelin gene (GHRL), and produced by the stomach [13]. Their potential roles in uremic PEW have been investigated in adults [14], [15], [16] and, to a lesser extent, in pediatric CKD [17], [18], [19], with contradictory issues.…”

Section: Introductionmentioning

confidence: 99%

Protein Energy Wasting in a Sample of Egyptian Children on Regular Hemodialysis: Relation to Anorexigenic Hormones

Said¹,

Wakeel²,

El-Kassas³

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Increased incidence of pediatric end-stage renal disease (ESRD) with associated serious consequences indicating a major public health problem. Malnutrition and uremic wasting are leading causes of growth impairment and increasing morbidity and mortality of pediatric ESRD patients, predominantly those on regular hemodialysis (HD). Ghrelin and obestatin, which are known appetite regulatory hormones, might have a pivotal role in uremic wasting and growth impairment in hemodialyzed children. AIM: The aim of the present study was to measure serum unacylated ghrelin (UAG) and obestatin and to investigate their roles in the growth impairment of Egyptian hemodialyzed children. SUBJECTS AND METHODS: The study included 50 hemodialyzed and 40 healthy children recruited from the Department of Nephrology, Pediatric Hospital, Ain Shams University. Full clinical examination and measurement of anthropometric indices were done. Routine labs were done as well, with an assessment of serum levels of obestatin, UAG, and insulin by enzyme linked immunosorbent assay. Furthermore, we determined fasting serum glucose and lipid profile with the calculation of homeostasis model assessment for insulin resistance (HOMA-IR). RESULTS: Anthropometric measurements were statistically significantly decreased in the hemodialyzed group than that of the control group (p < 0.05). Weight z-score was the most affected anthropometric parameter (37 patients = 74% with underweight and 13 patients = 26% with normal weight). The hemodialyzed children showed a significant increase of UAG, obestatin, insulin, glucose, HOMA-IR, and TG, while a significant decrease of HDL-cholesterol and albumin (p < 0.01). UAG had a negative correlation with Wt-z score, Ht z-score, fat mass %, albumin, and TG while obestatin was inversely correlated to Wt-z score, BMI z-score, waist circumference, and waist-height ratio (W/H). CONCLUSION: UAG and obestatin hormones were elevated in a group of Egyptian children on regular HD. These hormones were strongly related to the impairment of renal functions, and anthropometric parameters, dyslipidemia, hypoalbuminemia, and insulin resistance in these pediatric hemodialyzed patients.

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Association of cord blood des-acyl ghrelin with Apgar score and anthropometric measures in relation to its maternal one.

Cited by 2 publications

References 41 publications

Role of Inflammatory Cytokines in Obese and Nonobese Diabetic Children

Role of Inflammatory Cytokines in Obese and Nonobese Diabetic Children

Protein Energy Wasting in a Sample of Egyptian Children on Regular Hemodialysis: Relation to Anorexigenic Hormones

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