2011
DOI: 10.3748/wjg.v17.i6.708
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Association of core promoter mutations of hepatitis B virus and viral load is different in HBeAg(+) and HBeAg(-) patients

Abstract: The percentage of HBeAg(-) patients is high in Indonesia, and most of the HBeAg(-) patients had been seroconverted. The A1896 mutation was most likely the major cause of HBeAg loss. The T1762/A1764 mutation alone was associated with lower viral loads in HBeAg(+) patients, but not in HBeAg(-) patients.

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Cited by 9 publications
(4 citation statements)
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“…Within our asymptomatic donors BCP and PC mutations were very common, even though these have been linked to disease progression . No association was found between these mutations, either independently or in a dual mutation profile, and HBV viral load despite other studies finding links between their presence and high viral loads . There is clearly a link, however, between the prevalence of these mutations and the specific genotype of the virus, and it appears that those genotypes (A and C) with a higher propensity for BCP mutations are also less likely to have the PC mutations and vice versa.…”
Section: Discussioncontrasting
confidence: 58%
See 1 more Smart Citation
“…Within our asymptomatic donors BCP and PC mutations were very common, even though these have been linked to disease progression . No association was found between these mutations, either independently or in a dual mutation profile, and HBV viral load despite other studies finding links between their presence and high viral loads . There is clearly a link, however, between the prevalence of these mutations and the specific genotype of the virus, and it appears that those genotypes (A and C) with a higher propensity for BCP mutations are also less likely to have the PC mutations and vice versa.…”
Section: Discussioncontrasting
confidence: 58%
“…2,13,28 No association was found between these mutations, either independently or in a dual mutation profile, and HBV viral load despite other studies finding links between their presence and high viral loads. 29,30 There is clearly a link, however, between the prevalence of these mutations and the specific genotype of the virus, and it appears that those genotypes (A and C) with a higher propensity for BCP mutations are also less likely to have the PC mutations and vice versa. These findings suggest a more complex relationship between the virus and severity of liver disease than simply the presence of these mutations.…”
Section: Discussionmentioning
confidence: 99%
“…One study reported that the T1762/A1764 mutations occurred frequently in patients with viral loads rising to over 10 6 copies/mL regardless of the presence of HBeAg,33 while another study reported that the effect of T1762/A1764 mutation on viral replication differed according to the presence of HBeAg. That is, T1762/A1764 mutations were associated with reduced HBV DNA levels in HBeAg-positive patients but not in HBeAg-negative patients 34. Another significant naturally double mutation is A1896/A1899.…”
Section: Discussionmentioning
confidence: 97%
“…Several molecular epidemiological studies of HBV have been carried out in Indonesia. Particularly, HBV genotype and basal core promoter mutations prevalence in blood donors and HBV‐associated liver disease patients and their association with the progress of liver disease and HBV DNA have been reported previously [Utama et al, 2009a,b, 2011]. So far, however, there is no report about the prevalence of pre‐S mutations in Indonesian patients.…”
Section: Introductionmentioning
confidence: 94%