2017
DOI: 10.29333/ejgm/81878
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Association of coronary artery disease severity and disulphide/native thiol ratio

Abstract: Objective: Oxidative stress is among the major components of cardiovascular disease pathogenesis. Thiols play a significant role in prevention of oxidative stress in the cell. The purpose of this study is to investigate the relationship between the severity of coronary artery disease and disulphide/native thiol ratio, also determine if this ratio can be used as a marker of oxidative stress in this population. Methods: A total number of 107 patients with angiographically established coronary artery disease and … Show more

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Cited by 6 publications
(8 citation statements)
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“…Stability of thiols and disulphides have been assessed in various samples including plasma and were found to be stable at −80 °C for at least 6 months [ 194 ]. Most clinical applications have been originating from Turkey, focussing on CVD [ 195 ], respiratory diseases and metabolic disorders [ 27 ], as well as cancer, ageing, and neurodegenerative diseases [ 196 ], though the relevance for localized diseases such as cancer has been questioned in the same review. The disulphide/native thiol ratio has also been measured in obese children and was elevated compared to non-obese children [ 197 ].…”
Section: Markers Of Os Relation To Disease and Practical Aspectsmentioning
confidence: 99%
“…Stability of thiols and disulphides have been assessed in various samples including plasma and were found to be stable at −80 °C for at least 6 months [ 194 ]. Most clinical applications have been originating from Turkey, focussing on CVD [ 195 ], respiratory diseases and metabolic disorders [ 27 ], as well as cancer, ageing, and neurodegenerative diseases [ 196 ], though the relevance for localized diseases such as cancer has been questioned in the same review. The disulphide/native thiol ratio has also been measured in obese children and was elevated compared to non-obese children [ 197 ].…”
Section: Markers Of Os Relation To Disease and Practical Aspectsmentioning
confidence: 99%
“…-Protein oxidation marker -Protein Thiol/Free Thiol. Thiols are organic compounds that contain a sulfhydryl group(-SH) (195)(196)(197). Among the antioxidants prevailing in the body, thiol constitutes the significant share of the total body antioxidants, plays a crucial role in defense against ROS, and ameliorates ROS's lipid peroxidative effects.…”
Section: Biomarkers Of Oxidative Stressmentioning
confidence: 99%
“…Among the antioxidants prevailing in the body, thiol constitutes the significant share of the total body antioxidants, plays a crucial role in defense against ROS, and ameliorates ROS's lipid peroxidative effects. So total thiol is a critical antioxidant in body fluid, and mammalian tissue is rich in protein thiol (20-40mM) (195,196). A significant part of thiol in plasma is derived from albumin and protein thiol and, to a lesser extent, by low molecular weight thiols such as cysteinyl glycine, cystine, homocysteine, glutathione, and γglutamylcysteine (195,198).…”
Section: Biomarkers Of Oxidative Stressmentioning
confidence: 99%
“…Increased vascular oxidative stress, characterized by an increase in reactive oxygen species (ROS), is caused by an imbalance between ROS-producing and -degrading enzyme systems. An increase in ROS levels can lead to thiol oxidation, which has been shown to be higher in ischemic heart disease patients [ 34 , 35 ]. Further, increased ROS can contribute to activation of redox-dependent inflammatory mediators exacerbating inflammation.…”
Section: Mechanisms Of Cmdmentioning
confidence: 99%