Association of corynebacteria with granulomatous mastitis

Mathelin, Carole; Riegel, Philippe; Chenard, Marie–Pierre; Brettes, Jean-Philippe

doi:10.1016/j.ejogrb.2004.08.003

Cited by 19 publications

(15 citation statements)

References 2 publications

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“…Nevertheless, corynebacteria are common mastitis agents in ruminants (Contreras and Rodríguez, 2011) and they are the main cause of human granulomatous mastitis (Taylor et al, 2003; Mathelin et al, 2005). Rothia spp.…”

Section: Discussionmentioning

confidence: 99%

Identification of Emerging Human Mastitis Pathogens by MALDI-TOF and Assessment of Their Antibiotic Resistance Patterns

Marín

Arroyo²,

Espinosa-Martos³

et al. 2017

Front. Microbiol.

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Lactational mastitis constitutes one of the main causes of undesired weaning, depriving the mother–infant pair from the benefits of breastfeeding; therefore, this condition should be considered a relevant public health issue. The role of specific microorganisms remains unclear since human milk cultures and antibiotic susceptibility testing (AST) are not routinely performed, despite the fact that this would be key to ensure an early and effective diagnosis and treatment. The objective of this study was to describe the culturable microbial diversity in 647 milk samples from breastfeeding women with clinical symptoms of mastitis by Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF) VITEK MS technology and to analyze the antimicrobial susceptibility profiles of a collection of isolates from these samples by the VITEK 2 AST system. Staphylococcus epidermidis was the most common species isolated from mastitis samples (87.6%), while Staphylococcus aureus was detected in 22.1%. Streptococci constituted the second (68.6%) most prevalent bacterial group, with Streptococcus mitis/oralis, Streptococcus salivarius, and Streptococcus parasanguinis detected with frequencies of 40.8, 36.8, and 14.4%, respectively. The antibiotic susceptibility profiles of 642 staphylococcal isolates indicated a remarkable resistance to benzylpenicillin (88.3%) and erythromycin (67.3%) with differences between species. A high percentage of Staphylococcus isolates were resistant to at least one antibiotic (Staphylococcus hominis, 100%; S. epidermidis, 98.2%; S. aureus, 92.9%; Staphylococcus lugdunensis, 90.5%) and the percentage of multidrug-resistance (MDR) isolates was noticeable (S. hominis, 81%; S. epidermidis, 64.4%; S. aureus, 11.5%; S. lugdunensis, 10.5%). In relation to streptococcal isolates (n = 524), AST revealed high or moderate percentages of resistance to erythromycin (68.7%), benzylpenicillin (63.7%), ampicillin (51.5%), and tetracycline (30.8%). Antibiotic resistance to at least one antibiotic was detected in 97.6% of S. parasanguinis, 92.6% of S. salivarius, 83.3% of S. mitis/oralis, and 72.4% of Streptococcus vestibularis isolates. A significant number of MDR streptococcal isolates was also found (S. parasanguinis, 51.2%; S. salivarius, 39.3%; S. mitis/oralis, 34.6%; and S. vestibularis, 19%). The results highlight the important role of coagulase-negative staphylococci and streptococci as human mastitis-causing agents. Moreover, the high rates of antimicrobial resistance among these microorganisms must be contemplated as an issue of clinical relevance in relation to treatment options.

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Section: Discussionmentioning

confidence: 99%

Identification of Emerging Human Mastitis Pathogens by MALDI-TOF and Assessment of Their Antibiotic Resistance Patterns

Marín

Arroyo²,

Espinosa-Martos³

et al. 2017

Front. Microbiol.

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“…It typically affects younger women, usually within 5 years of pregnancy (49 -51). Inflammatory factors have been suggested as a possible cause (52,53), but a recent study isolated Corynebacterium in up to 75% of cases (54,55).…”

Section: Granulomatous Mastitismentioning

confidence: 97%

“…Primary treatment has classically been based on excisional biopsy (48 -52,56,57), but close surveillance without surgery has also proved adequate in the management of cases involving spontaneous resolution (58). If Corynebacterium is isolated with microbiologic or pathologic studies, antibiotic therapy based on the administration of penicillin and tetracycline should be effective (54,55).…”

Section: Granulomatous Mastitismentioning

confidence: 99%

Radiologic Evaluation of Breast Disorders Related to Pregnancy and Lactation

Sabaté

Clotet²,

Torrubia³

et al. 2007

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204

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During pregnancy and lactation, the breast can be affected by a variety of specific and unique disorders, including benign disorders closely related to physiologic changes, inflammatory and infectious diseases, juvenile papillomatosis, and benign and malignant tumors. Patients with pregnancy-associated breast carcinoma tend to have more advanced neoplasms at diagnosis and a poorer prognosis due to delayed diagnosis and a more aggressive biologic pattern. Pregnancy-related Burkitt lymphoma characteristically manifests with bilateral and diffuse involvement of the breasts. Fibroadenoma may manifest with growth, infarction, large cysts, prominent ducts, and secretory hyperplasia during pregnancy and lactation. Galactocele is the breast lesion most commonly found during lactation and manifests as either pseudolipoma, a cystic mass with a fat-fluid level, or pseudohamartoma. Tumors and diseases affecting the breasts during pregnancy and lactation are basically the same as those observed in nonpregnant women but may have a different appearance. The sensitivity of mammography in pregnant and lactating women is decreased due to increased parenchymal density. Instead, ultrasonography is the most appropriate radiologic method for evaluating breast masses in this setting and is particularly useful in the diagnosis and treatment of abscesses. Knowledge of the unique entities that are specifically related to pregnancy and lactation and of their radiologic-pathologic appearances can help the radiologist make the correct diagnosis.

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“…The pathophysiology of the disease remains unknown. Recent reports claim a relationship between corynebacterium infection and IGM [5][6][7]. IGM typically affects women of childbearing age, and most patients have a recent history of breast feeding [8].…”

Section: Introductionmentioning

confidence: 99%

Combined Long-Term Steroid and Immunosuppressive Treatment Regimen in Granulomatous Mastitis

Konan

Kalyoncu²,

Doğan³

et al. 2012

Breast Care

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Background: Idiopathic granulomatous mastitis (IGM) is a rare benign inflammatory disease of the breast. It is related to various etiological factors. The treatment of IGM is challenging as there is a lack of consensus in the literature and treatment options vary widely. Conservative treatment with antibiotics, glucocorticoids and immunosuppressive drugs, and surgery are used in the management of the disease. In this article we report our experience with IGM patients receiving immunosuppressive treatment. Patients and Methods: The medical records of patients with IGM receiving systemic therapy at the Hacettepe University Hospital between October 2007 and May 2010 were reviewed. 15 cases of histopathologically proven IGM were identified. The data was examined for risk factors and success of treatment. Results: 14 patients were given prednisolone together with azathioprine, and 1 patient who was pregnant at the time of diagnosis received only prednisolone (30 mg/day). 11 (73%) patients had a complete response to systemic therapy. 2 patients had a relapse, of whom 1 required surgical drainage and 1 was treated with a higher dose of glucocorticoids. Conclusion: Systemic therapy is a safe and effective treatment for IGM. The addition of azathioprine to glucocorticoid therapy permits quick tapering of the steroid doses and increases the treatment success.

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Association of corynebacteria with granulomatous mastitis

Cited by 19 publications

References 2 publications

Identification of Emerging Human Mastitis Pathogens by MALDI-TOF and Assessment of Their Antibiotic Resistance Patterns

Identification of Emerging Human Mastitis Pathogens by MALDI-TOF and Assessment of Their Antibiotic Resistance Patterns

Radiologic Evaluation of Breast Disorders Related to Pregnancy and Lactation

Combined Long-Term Steroid and Immunosuppressive Treatment Regimen in Granulomatous Mastitis

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