Association of COVID-19 Vaccination With Risk for Incident Diabetes After COVID-19 Infection

Abstract

This cohort study compares the risk of new-onset hypertension, hyperlipidemia, and diabetes before and after COVID-19 infection among patients who were vaccinated vs unvaccinated before infection.

COVID-19 and Incident Diabetes—Recovery Is Not So Sweet After All

“…In addition, they provide compelling evidence that the increase in diagnoses of diabetes was associated with severity of COVID-19, with a hazard ratio of 2.42 (95% CI, 1.87-3.15) for persons hospitalized with COVID-19, and a hazard ratio of 3.29 (95% CI, 1.98-5.48) for those who required intensive care. 1 For those with severe COVID-19, the increase in new diagnoses of diabetes was significant for women as well. Results were significant only for non-insulin-dependent diabetes, although this finding may not represent a clean separation into type 2 and type 1 disease.…”

“…Post–COVID-19 condition (colloquially called long COVID ) is the most frequent of the postacute sequelae of COVID-19, but SARS-CoV-2 infection can trigger or accelerate other debilitating and costly chronic diseases, including cardiac and neurological disorders. Naveen and colleagues add their Canadian study to the international reports of increased occurrence of diabetes following SARS-CoV-2 infection. A meta-analysis of reports from the US, Norway, the UK, Germany, and multisite consortia found an overall 66% increase in the incidence of new-onset diabetes following SARS-CoV-2 infection.…”

“…However, in a US study using electronic health records that was restricted to children with a specified diagnoses of type 1 diabetes, even children younger than 10 years of age had an increased risk of new diagnoses. Naveen and colleagues report a significant, although modest, increase in new diagnosis of diabetes in British Columbia, Canada, among adult men following SARS-CoV-2 infection compared with men who tested negative for SARS-CoV-2 at about the same time. In addition, they provide compelling evidence that the increase in diagnoses of diabetes was associated with severity of COVID-19, with a hazard ratio of 2.42 (95% CI, 1.87-3.15) for persons hospitalized with COVID-19, and a hazard ratio of 3.29 (95% CI, 1.98-5.48) for those who required intensive care .…”

“…Naveen and colleagues report a significant, although modest, increase in new diagnosis of diabetes in British Columbia, Canada, among adult men following SARS-CoV-2 infection compared with men who tested negative for SARS-CoV-2 at about the same time. In addition, they provide compelling evidence that the increase in diagnoses of diabetes was associated with severity of COVID-19, with a hazard ratio of 2.42 (95% CI, 1.87-3.15) for persons hospitalized with COVID-19, and a hazard ratio of 3.29 (95% CI, 1.98-5.48) for those who required intensive care . For those with severe COVID-19, the increase in new diagnoses of diabetes was significant for women as well.…”

“…Results were significant only for non–insulin-dependent diabetes, although this finding may not represent a clean separation into type 2 and type 1 disease. This study represents a population-based investigation that adds to the existing literature suggesting an increased risk for developing diabetes following COVID-19.…”