Association of criteria pollutants with plasma hemostatic/inflammatory markers: a population-based study

Liao, Duanping; Heiss, Gerardo; Chinchilli, Vernon M.; Duan, Yinkang; Folsom, Aaron R.; Lin, Hung Mo; Salomaa, Veikko

doi:10.1038/sj.jea.7500408

Cited by 109 publications

(87 citation statements)

References 49 publications

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“…Some of them showed increased levels of FVII [12], fibrinogen [9,19,21] and von Willebrand factor [18,20]. On the other hand, other studies that measured the same factors found decreased levels or no association with air pollution exposure [17,20,[38][39][40][41].…”

Section: Discussionmentioning

confidence: 99%

Effects of exposure to air pollution on blood coagulation

Baccarelli

Zanobetti²,

Martinelli

et al. 2007

Journal of Thrombosis and Haemostasis

197

130

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Summary. Background: Consistent evidence has indicated that air pollution increases the risk of cardiovascular diseases. The underlying mechanisms linking air pollutants to increased cardiovascular risk are unclear. Objectives: We investigated the association between the pollution levels and changes in such global coagulation tests as the prothrombin time (PT) and the activated partial thromboplastin time (APTT) in 1218 normal subjects from the Lombardia Region, Italy. Plasma fibrinogen and naturally occurring anticoagulant proteins were also evaluated. Methods: Hourly concentrations of particulate (PM 10 ) and gaseous pollutants (CO, NO 2 , SO 2 , and O 3 ) were obtained from 53 monitoring sites covering the study area. Generalized additive models were applied to compute standardized regression coefficients controlled for age, gender, body mass index, smoking, alcohol, hormone use, temperature, day of the year, and long-term trends. Results: The PT became shorter with higher ambient air concentrations at the time of the study of PM 10 (coefficient ¼ )0.06; P < 0.05), CO (coefficient ¼ )0.11; P < 0.001) and NO 2 (coefficient ¼ )0.06; P < 0.05). In the 30 days before blood sampling, the PT was also negatively associated with the average PM 10 (coefficient ¼ )0.08; P < 0.05) and NO 2 (coefficient ¼ )0.08; P < 0.05). No association was found between the APTT and air pollutant levels. In addition, no consistent relations with air pollution were found for fibrinogen, antithrombin, protein C and protein S. Conclusions: This investigation shows that air pollution is associated with changes in the global coagulation function, suggesting a tendency towards hypercoagulability after short-term exposure to air pollution. Whether these changes contribute to trigger cardiovascular events remains to be established.

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Section: Discussionmentioning

confidence: 99%

Effects of exposure to air pollution on blood coagulation

Baccarelli

Zanobetti²,

Martinelli

et al. 2007

Journal of Thrombosis and Haemostasis

197

130

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“…154 Riediker 157 found that components of in-vehicle PM 2.5 were also related to increased von Willebrand factor and decreased protein C among highway patrol troopers. In the Atherosclerosis Risk in Communities study, a 12.8-g/m 3 elevation in ambient PM 10 was associated with a 3.9% higher von Willebrand factor level, 173 but only among those with diabetes. There was no linkage between PM 10 exposure and fibrinogen or white blood cell levels.…”

Section: Thrombosis and Coagulationmentioning

confidence: 95%

Particulate Matter Air Pollution and Cardiovascular Disease

Brook¹,

Rajagopalan²,

Pope³

et al. 2010

Circulation

5,443

3,225

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Abstract-In 2004, the first American Heart Association scientific statement on "Air Pollution and Cardiovascular Disease" concluded that exposure to particulate matter (PM) air pollution contributes to cardiovascular morbidity and mortality. In the interim, numerous studies have expanded our understanding of this association and further elucidated the physiological and molecular mechanisms involved. The main objective of this updated American Heart Association scientific statement is to provide a comprehensive review of the new evidence linking PM exposure with cardiovascular disease, with a specific focus on highlighting the clinical implications for researchers and healthcare providers. The writing group also sought to provide expert consensus opinions on many aspects of the current state of science and updated suggestions for areas of future research. On the basis of the findings of this review, several new conclusions were reached, including the following: Exposure to PM Ͻ2.5 m in diameter (PM 2.5 ) over a few hours to weeks can trigger cardiovascular disease-related mortality and nonfatal events; longer-term exposure (eg, a few years) increases the risk for cardiovascular mortality to an even greater extent than exposures over a few days and reduces life expectancy within more highly exposed segments of the population by several months to a few years; reductions in PM levels are associated with decreases in cardiovascular mortality within a time frame as short as a few years; and many credible pathological mechanisms have been elucidated that lend biological plausibility to these findings. It is the opinion of the writing group that the overall evidence is consistent with a causal relationship between PM 2.5 exposure and cardiovascular morbidity and mortality. This body of evidence has grown and been strengthened substantially since the first American Heart Association scientific statement was published. Finally, PM 2.5 exposure is deemed a modifiable factor that contributes to cardiovascular morbidity and mortality. (Circulation. 2010;121:2331-2378.)

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“…Similarly, investigation of blood biomarkers (reflecting haemostasis and inflammation) of cardiovascular risk in panel studies have provided inconsistent associations with ozone, complicated by the different averaging times and lag structures examined (Rudez et al, 2009;Thompson et al, 2010;Chuang et al, 2007;Liao et al, 2005;Steinvil et al 2008).…”

Section: Experimental and Panel Studiesmentioning

confidence: 99%

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

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This document presents answers to 24 questions relevant to reviewing European policies on air pollution and to addressing health aspects of these policies. The answers were developed by a large group of scientists engaged in the WHO project "Review of evidence on health aspects of air pollution -REVIHAAP". The experts reviewed and discussed the newly accumulated scientific evidence on the adverse effects on health of air pollution, formulating science-based answers to the 24 questions. Extensive rationales for the answers, including the list of key references, are provided. The review concludes that a considerable amount of new scientific information on the adverse effects on health of particulate matter, ozone and nitrogen dioxide, observed at levels commonly present in Europe, has been published in recent years. This new evidence supports the scientific conclusions of the WHO air quality guidelines, last updated in 2005, and indicates that the effects in some cases occur at air pollution concentrations lower than those serving to establish these guidelines. It also provides scientific arguments for taking decisive actions to improve air quality and reduce the burden of disease associated with air pollution in Europe.This publication arises from the project REVIHAAP and has been co-funded by the European Union. Keywords AIR POLLUTANTS AIR POLLUTION -ADVERSE EFFECTS ENVIRONMENT AND PUBLIC HEALTH EVIDENCE BASED PRACTICE GUIDELINES HEALTH POLICYAddress requests about publications of the WHO Regional Office for Europe to: Publications WHO Regional Office for Europe Scherfigsvej 8 DK-2100 Copenhagen Ø, Denmark Alternatively, complete an online request form for documentation, health information, or for permission to quote or translate, on the Regional Office web site (http://www.euro.who.int/pubrequest). © World Health Organization 2013All rights reserved. The Regional Office for Europe of the World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full.The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate borderlines for which there may not yet be full agreement.The mention of specific companies or of certain manufacturers products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either express or implied. ...

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Association of criteria pollutants with plasma hemostatic/inflammatory markers: a population-based study

Cited by 109 publications

References 49 publications

Effects of exposure to air pollution on blood coagulation

Effects of exposure to air pollution on blood coagulation

Particulate Matter Air Pollution and Cardiovascular Disease

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

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