Association of CTLA-4 variants with susceptibility to inflammatory bowel disease: A meta-analysis

Zhang, Min; Ni, Jing; Xu, Wang‐Dong; Wen, Pengfei; Qiu, Lijuan; Wang, Xiaosong; Pan, Hai‐Feng; Ye, Dong-Qing

doi:10.1016/j.humimm.2013.12.008

Cited by 25 publications

(16 citation statements)

References 57 publications

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“…Ulcerative Colitis (UC) is a chronic relapsing and remitting intestinal inflammatory disorder that is confined to the mucosal and submucosal layers of rectum and colon, invading epithelial lining of the gut [1, 2]. The etiology and pathogenesis of UC are still unclear, but the epidemiological data have suggested that genetic variation is a major risk factor for the evolution of UC [3, 4].…”

Section: Introductionmentioning

confidence: 99%

IL-23R mutation is associated with ulcerative colitis: A systemic review and meta-analysis

Peng

Wang²,

Zhu

et al. 2016

Oncotarget

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ObjectivesSince a genome-wide association study revealed that Interleukin-23 receptor (IL-23R) gene is a candidate gene for Ulcerative Colitis (UC), many studies have investigated the association between the IL-23R polymorphisms and UC. However, the results were controversial. The aim of the study was to determine whether the IL-23R polymorphisms confer susceptibility to UC.MethodsA systematic literature search was carried out to identify all potentially relevant studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of association.ResultsA total of 33 studies in 32 articles, including 10,527 UC cases and 15,142 healthy controls, were finally involved in the meta-analysis. Overall, a significant association was found between all UC cases and the rs11209026A allele (OR = 0.665, 95% CI = 0.604~0.733, P < 0.001). Similarly, meta-analyses of the rs7517847, rs1004819, rs10889677, rs2201841, rs11209032, rs1495965, rs1343151 and rs11465804 polymorphisms also indicated significant association with all UC (all P < 0.05). Stratification by ethnicity revealed that the rs11209026, rs7517847, rs10889677, rs2201841 andrs11465804 polymorphisms were associated with UC in the Caucasian group, but not in Asians, while the rs1004819 and rs11209032 polymorphisms were found to be related to UC for both Caucasian and Asian groups. However, subgroup analysis failed to unveil any association between the rs1495965 and rs1343151 polymorphisms and UC in Caucasians or Asians.ConclusionsThe meta-analysis suggests significant association between IL-23R polymorphisms and UC, especially in Caucasians.

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Section: Introductionmentioning

confidence: 99%

IL-23R mutation is associated with ulcerative colitis: A systemic review and meta-analysis

Peng

Wang²,

Zhu

et al. 2016

Oncotarget

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“…Although some studies reported that PTPN22 does not influence the risk of IBD, including CD [12], other studies reported that PTPN22 may influence the risk of developing CD [13,14]. Moreover, some studies reported that CTLA4 may also influence the risk of developing CD [15,16]. Moreover, in a Spanish meta-analysis, the frequency of the minor allele rs1883832T of the CD40 gene was observed to be significantly higher in CD patients than that in control individuals, but it was not significantly higher in UC patients [17].…”

Section: Autoimmune Thyroid Diseasesmentioning

confidence: 99%

Autoimmune Thyroid Diseases Concomitant with Crohn’s Disease and Ulcerative Colitis

2014

Thyroid Disorders Ther

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The coexistence of Crohn's disease (CD) and autoimmune thyroid diseases [Graves' disease (GD) and Hashimoto's thyroiditis (HT)] is uncommon, although these conditions involve autoimmune processes. This report reviews the English and Japanese literature, including proceedings regarding coexisting CD and the autoimmune thyroid diseases GD and HT, and discusses cases of concomitant CD and GD (six cases) and CD and HT (12 cases), compared with reported concomitant cases of ulcerative colitis and GD.

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“…However, several immunological alterations have been found in these patients, such as HLA-DR antigen expression in thyrocytes, the presence of growth-stimulating immunoglobulins, and an increase in dendritic cells and lymphocytes, which suggest the possibility of autoimmune problems (1,(8)(9)(10). Although many of these findings may be an epiphenomenon of other primary defects in immunoregulation, the alteration of lymphocyte populations indicates a primary defect (6,7,10,(12)(13)(14)(15)(16)(17)(18). Variations in several genes have been studied as possible risk factors for Hashimoto thyroiditis.…”

Section: Introductionmentioning

confidence: 99%

Molecular-genetic mechanisms in development of degree of function and hyperplasia of thyroid gland of patients with nodular goiter with autoimmune thyroiditis and thyroid adenoma

Шеремет¹,

Sydorchuk²,

Shidlovskyі³

et al. 2019

Ro J Med Pract.

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Introduction. Autoimmune thyroiditis affects in average 2% to 5% of the general population, with young adult females and the elderly being the most vul-nerable patients. Hashimoto's thyroiditis causing hypothyroidism is the most prevalent etiology. Although genetics is well known to cause and influence the progression of autoimmune diseases in approximately 79%, other environmental factors are known to be involved in the development of autoimmune thyroid dis-eases: quantity of ingested iodine, stress, drugs, pregnancy, and changes in sexual hormones.Autoimmune thyroiditis, as a background disease of nodular goiter, in which hypothyroidism usually develops, has been insufficiently studied.Material and methods. The BCL-2 (rs17759659), CTLA-4 (rs231775), Fas (rs2234767) genes' polymorphism were studied by Real-Time Polymerase Chain Reaction in 95 patients with NGAIT, 30 patients with thyroid adenoma (TA) and 25 healthy individuals. The thyroid gland (TG) functional activity changes (nor-mal function, subclinical and clinical hypothyroidism) and TG hyperplasia degrees (IB, II and III) were analyzed.Results. TA and NGAIT are more common in the minor G-allele carriers (GА-and GG-genotypes) of the BCL-2 gene and in homozygous G allele patients (GG-genotype) of the Fas gene by 11.5 and 4.34 times (р<0.01), with no signifi-cant interdependence between the CTLA4 gene's genotypes. TG hyperplasia in patients' general cohort as well as in those with NGAIT is associated with the wild A alleles of the CTLA-4 gene (АА-and AG-genotypes): the І and ІІІ degree hy-perplasia occurred reliably more frequently in the AA genotype carriers, and ІІ degree of the TG enlargement in the AG genotype patients.Conclusions. Pathology of the thyroid gland has unreliable chances to be inherited depending on the polymorphism of BCL-2 (rs17759659), CTLA-4 (rs231775) and Fas (rs2234767) genes in Bukovina region (Western Ukraine). We did not find any difference between the relative incidences of the genotypes of the analyzed genes in the patients with NGAIT and those with TA or depending on the TG function (euthyroid goiter, subclinical and clinical hypothyroidism)..

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Association of CTLA-4 variants with susceptibility to inflammatory bowel disease: A meta-analysis

Cited by 25 publications

References 57 publications

IL-23R mutation is associated with ulcerative colitis: A systemic review and meta-analysis

IL-23R mutation is associated with ulcerative colitis: A systemic review and meta-analysis

Autoimmune Thyroid Diseases Concomitant with Crohn’s Disease and Ulcerative Colitis

Molecular-genetic mechanisms in development of degree of function and hyperplasia of thyroid gland of patients with nodular goiter with autoimmune thyroiditis and thyroid adenoma

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