Association of CYP19A1 Polymorphism with Genetic Susceptibility to Lung Cancer in Chinese population:a case-control study

Abstract

Background Lung cancer is a kind of cancer with high morbidity and mortality related to genetic factors. Many studies have shown that CYP19A1 gene polymorphism is associated with a variety of cancers, but there are few studies on lung cancer at present. The aim of the study was to explore the correlation between CYP19A1 polymorphisms and lung cancer risk in Chinese population.Methods We enrolled 510 lung cancer patients as the case group and 504 healthy people as the control group. Five single nucleotide polymorphisms determined in CYP19A1 gene were genotyped by MassARRAY, and correlation analysis was performed by Chi square test and logistic regression model.Results The genotypes of rs4646 (OR=0.77, p=0.010), rs6493487 (OR=0.76, p=0.006) and rs17601876 (OR=0.69, p=1.15E-04) in CYP19A1 gene were linked to decreasing the risk of lung cancer, while the rs1062033 (OR=1.49, p=0.029) was linked to increasing lung cancer risk. In gender-stratified analysis, female patients with the GG genotype of the rs6493487 (OR=0.31, p=0.037) and male patients with the rs17601876 (OR=0.52, p=0.012) had lower lung cancer risk. In age-stratified analysis, for patients ≥58 years, decreased lung cancer risk was correlated with the genotypes of rs4646 (OR=0.66, p=0.021), rs6493487 (OR=0.65, p=0.021) and rs17601876 (OR=0.39, p=0.001), and increased risk was associated with the GG genotype of rs1062033 (OR=2.09, p=0.003). In pathologic type-stratified analysis, the AA genotype of rs17601876 (OR=0.41, p=0.048) was associated with decreased risk of small cell lung cancer, and the AA genotype of rs4646 (OR=0.41, p=0.027), the GA genotype of rs6493487 (OR=0.65, p=0.024) and the AA genotype of rs17601876 (OR=0.34, p=0.005) were linked to decreased risk of squamous cell carcinoma.Conclusion CYP19A1 polymorphisms are associated with lung cancer risk, especially in elderly patients and patients with pathologic types of small cell lung cancer and squamous cell carcinoma.