Association of CYP24A1 gene polymorphism with colorectal cancer in the Jiamusi population

Abstract

Background The population in Jiamusi has been reported to have the highest prevalence of colorectal cancer (CRC) in China. The genetic causal-effect for this occurrence among the residents remains unclear. Given the long cold seasons with people wearing more clothes and reduced UV exposure, we aimed to study the association between the vitamin D metabolism-related gene CYP24A1 polymorphism and CRC susceptibility. Method A case-control study was conducted that included 168 patients with CRC and 710 age-matched healthy individuals as the control group. Plausible susceptible variations were sought and clinical phenotypic-genotype association analysis was performed. Results Overall, two CYP24A1 polymorphisms, rs6013905 AX (P = 0.02, OR = 1.89, 95%CI: 1.09–3.29) and rs2762939 GX (P = 0.02, OR = 1.52, 95%CI: 1.08–2.13) were significantly associated with CRC in the Jiamusi population. In the female group, three CYP24A1 polymorphisms, rs6013905 AX (P = 0.04, OR = 2.59, 95%CI: 1.03–6.49), rs2762939 GX (P = 0.01, OR = 2.35, 95%CI: 1.25–4.42), and rs6068816 GG (P = 0.05, OR = 1.89, 95%CI: 0.99–3.59) carriers were significantly associated with CRC. In clinical phenotypic-genotype analysis, rs6013905 GG (P = 0.05, OR = 4.00, 95%CI: 0.92–17.48) and rs2762939 GX (P = 0.03, OR = 4.87, 95%CI: 1.00–23.69) carriers were significantly associated with poorly differentiated CRC, while CYP24A1 rs6068816 AX was significantly associated with the tumor type (P = 0.02, OR = 2.08, 95%CI: 1.10–3.96) and location (P = 0.04, OR = 2.24, 95%CI: 1.05–4.77). Conclusion CYP24A1 gene polymorphism may be a genetic risk factor attributable to the highest prevalence of CRC in Jiamusi people. Individuals with CYP24A1 gene polymorphism may have an increased barrier for vitamin D absorption, thus contributing to the risk of CRC development.

Capsaicin and Cold exposure promote EMT-mediated premetastatic niche formation to facilitate colorectal cancer metastasis

“…Studies have shown that the occurrence and development of most colorectal cancer is related to environmental factors, such as dietary intake and the surrounding environment 1 , 2 . Epidemiological survey has indicated that cold exposure may not only be closely associated with high incidence of colorectal cancer, but also with malignant metastasis 3 . In addition, chili-pepper was positively associated with colorectal cancer incidence 4 .…”

The Association Between CYP24A1 rs4809957 Gene Polymorphism and Grade of Colorectal Cancer at Prof. Dr. I G.N.G Ngoerah Hospital in Bali

“…11 The CYP24A1 rs4809957 polymorphism AA genotype significantly increased the risk of CRC 2.38 (1.30-4.37) times (p = 0.005). Research by Chai et al (2021) shows that CYP24A1 polymorphisms are more common in low-grade CRC patients (p = 0.15). 24 Sun et al (2016) also found a similar study, which showed that CYP24A1 polymorphisms were more common in low-grade CRC patients with insignificant results (p = 0.137).…”

“…Research by Chai et al (2021) shows that CYP24A1 polymorphisms are more common in low-grade CRC patients (p = 0.15). 24 Sun et al (2016) also found a similar study, which showed that CYP24A1 polymorphisms were more common in low-grade CRC patients with insignificant results (p = 0.137). 11 Meanwhile, another study by Gong et al (2017) in China with 528 samples showed that the CYP24A1 rs4809957 A/G polymorphism had a statistically significant association with the risk of colon polyps, colon cancer and ulcerative colitis.…”

“…Meanwhile, the G allele is protective against CRC. 24 Alleles that do not match the base sequence will be destructive, thereby reducing the levels of protein produced. 25 People who have CYP24A1 gene polymorphism may have a higher barrier to vitamin D absorption, which raises the possibility of developing CRC.…”

“…25 People who have CYP24A1 gene polymorphism may have a higher barrier to vitamin D absorption, which raises the possibility of developing CRC. 24 Several factors could cause this difference in results. Most of the subjects in this study (88.2%) experienced low-grade CRC.…”