2023
DOI: 10.31557/apjcp.2023.24.12.4219
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Association of Cytidine Deaminase Polymorphism with Capecitabine Effectiveness in Breast Cancer Patients

Ali Amal Aldeen Majeed,
Ahmed Salih Sahib,
Hasanian Shakir Mahmood
et al.

Abstract: Objective: Cancer is caused by abnormal growth and disruption of homeostatic mechanisms. Breast cancer is a major health problem and the second leading cause of death in women. Capecitabine is a prodrug of 5-fluorouracil, which is a non-cytotoxic agent and is used to treat advanced or metastatic breast cancer. Cytidine deaminase (CDA) plays an important role in the activation of capecitabine by acetylating 5-deoxycytidine in the liver, which ultimately leads to the formation of 5-fluorouracil. In … Show more

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