Association of decrease in serum dehydroepiandrosterone sulfate levels with the progression to type 2 diabetes in men of a Japanese population: The Fungata Study

The aim of this study was to confirm if there is a link between the alteration in blood levels of trace elements (chromium, copper, lead, cadmium, and zinc) and dehydroepiandrosterone sulfate (DHEAS) in healthy and diabetic states. This study is the first study to test these parameters in Egyptians. The study included 150 subjects divided into the following four groups: healthy middle-aged, healthy elderly, middle-aged diabetics, and elderly diabetics. Our results revealed a statistically significant decrease in the level of DHEAS in the elderly compared to middle-aged healthy and diabetic groups (p < 0.05). There was a significant difference between the middle-aged groups with respect to zinc, copper, chromium, and cadmium levels. Zinc and copper were lower in the diabetic subjects while chromium and cadmium were higher in the same group in comparison to healthy subjects. In the elderly groups, there were significant increases in chromium and cadmium levels in diabetic subjects rather than healthy ones. There was a significant increase in the thiobarbituric acid reactive substance level in the elderly healthy and diabetic groups and a significant decrease in the glutathione level in the elderly groups. There was no correlation between the levels of trace elements and DHEAS or between the levels of DHEAS, oxidants, and antioxidants in all of the tested groups. In conclusion, only the DHEAS level was correlated with age. There was no difference between the diabetic and healthy groups with respect to the levels of trace elements, with the exception of chromium and cadmium, which suggests the effect of pollution on the pathogenesis of diabetes in Egyptians. No correlation existed between the levels of DHEAS and trace elements, oxidants, and antioxidants. Finally, we believe that there is a large regional variation in the levels of trace elements due to different environmental exposure and nutritional factors which are responsible for contradictory results regarding the pathogenesis of diseases related to alterations in the levels of trace elements.

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“…This is similar to what was reported, that starting at 50 years of age a significant age-related decrease in DHEAS is observed [27,28].…”

Section: Discussionsupporting

confidence: 93%

Impact of Trace Element Changes on Dehydroepiandrosterone Sulfate in Healthy and Diabetic States among Middle-Age and Elderly Egyptians

Husseiny

Said

Mohamed³

et al. 2011

Biol Trace Elem Res

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“…A greater effect of DHEAS on insulin resistance and potentially frank diabetes in PCOS may be found by studying the change in DHEAS over time (17). HOMA-IR has been shown to correlate well to insulin-mediated glucose disposal as assessed by the glucose clamp technique, and is thus a valuable predictor of insulin resistance, although it may be a less accurate measure of insulin action in patients with PCOS (33,36).…”

Section: Discussionmentioning

confidence: 99%

“…Low DHEAS levels have been associated with coronary artery disease in men (14)(15)(16). Although the mechanism underlying this association is unclear, a study of a Japanese population found that a decrease of serum DHEAS levels over a period of time is significantly associated with the development of DM in men (17), suggesting a complex interaction between DHEAS and insulin and the development of cardiovascular disease and DM. DHEAS levels have also been shown to decrease with age, as does insulin action (18)(19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

Dehydroepiandrosterone sulfate and insulin resistance in patients with polycystic ovary syndrome

Brennan

Huang

Azziz

2009

Fertility and Sterility

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“…DHEAS supplementation in women aged 40 to 70 years leads to an increase in insulin like growth factor (IGF-1) levels as well as an improvement of physical and psychological well-being but without a significant change in insulin sensitivity [15][16][17]. Further Kameda et al found that decreased level of DHEAS is associated with the development of type 2 DM [18].…”

Section: Discussionmentioning

confidence: 99%

Determination of Source of Hyperandrogenism and Comparisons of Hormonal and Metabolic Profile in Different Phenotype of PCOS: A Hospital Based Study

Agrawala¹,

Chudhury²,

Mohanty³

et al. 2017

J Diabetes Metab

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Objective: Metabolic parameters in polycystic ovary syndrome (PCOS) correlate to their phenotypic presentations and sources of hyperandrogenism. Till date no studies have evaluated the source of hyperandrogenism among phenotypic variants of PCOS. Therefore we determined the sources of hyperandrogenism and compared the metabolic parameters in different phenotypes of PCOS. Result: This study had 2 phenotypic presentations i.e. PHO (80%) and OH (20%) out of 4 phenotypic presentations described by Rotterdam among all PCOS (may be due to referral bias). Among obese PCOS 87.5% had PHO and 12.5% had OH phenotypes, while it was 75% and 25% in normal weight PCOS. PHO phenotypes had adrenal and ovarian source of hyperandrogenism. Fasting insulin and HOMA-IR were higher in non-obese PHO than obese PHO but statistically insignificant. Serum DHEAS (delta steroid) had a negative but serum testosterone (keto steroid) had positive correlation with IR in PCOS. Conclusion:Both adrenal and ovarian hyperandrogenism was found in PHO as compared to OH phenotype that had only ovarian hyperandrogenism. Normal weight PCOS had less chance of getting ultrasound abnormalities compared to obese PCOS. PHO phenotypes, who had a greater degree of serum DHEAS had a better metabolic profile despite a greater BMI. So our result suggests that distinction between source of hyperandrogenism and evaluation of different phenotype is beneficial in predicting metabolic risk and future management.

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Association of decrease in serum dehydroepiandrosterone sulfate levels with the progression to type 2 diabetes in men of a Japanese population: The Fungata Study

Cited by 37 publications

References 36 publications

Impact of Trace Element Changes on Dehydroepiandrosterone Sulfate in Healthy and Diabetic States among Middle-Age and Elderly Egyptians

Impact of Trace Element Changes on Dehydroepiandrosterone Sulfate in Healthy and Diabetic States among Middle-Age and Elderly Egyptians

Dehydroepiandrosterone sulfate and insulin resistance in patients with polycystic ovary syndrome

Determination of Source of Hyperandrogenism and Comparisons of Hormonal and Metabolic Profile in Different Phenotype of PCOS: A Hospital Based Study

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