Association of decreased myonectin levels with metabolic and hormonal disturbance in polycystic ovary syndrome

Demir, İsmail; Güler, Aslı

doi:10.1080/09513590.2020.1751109

Cited by 11 publications

(17 citation statements)

References 16 publications

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“…It has been demonstrated that irisin and myonectin are associated with many diseases such as T2DM, polycystic ovary syndrome ▶Table 1 Comparison of clinical and biochemical parameters in GDM and control groups. (PCOS), myocardial infarction, obesity, and IR [8][9][10][13][14][15][16]. Pre viously, irisin has been studied many times in patients with GDM.…”

Section: Discussionmentioning

confidence: 99%

“…The increase in myonectin levels, which were measured 6 months after the procedure in obese patients who underwent bariatric surgery (laparoscopic sleeve gastrectomy), compared to the pre-operation levels support these fi ndings [ 25 ] . In their study, Demir and Guler [ 15 ] compared myonectin levels of women with PCOS, a metabolic disease, vs. healthy controls, and underscored that myonectin levels were correlated with hormonal and metabolic disorders present in PCOS. In our study, the fi ndings showed that serum myonectin level was signifi cantly lower among the GDM group, and there was a negative correlation between myonectin and pre-gestational BMI, HOMA-IR, HbA1c, FSI, and FSG.…”

Section: Gdmmentioning

confidence: 99%

“…In addition, it is secreted from erythroblasts to pro vide mobilization of iron from the liver in response to blood loss [12]. It has been revealed that myonectin could be associated with cardiovascular disease, polycystic ovary syndrome, obesity, T2DM, and insulin resistance [13][14][15][16]. The literature review revealed that the correlation between myonectin and GDM has not been pre viously investigated.…”

Section: Introductionmentioning

confidence: 99%

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Circulating Myonectin and Irisin Levels in Gestational Diabetes Mellitus – A Case-control Study

Onat

2021

Z Geburtshilfe Neonatol

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Objective The objective of this study was to assess the levels of serum myonectin and irisin in pregnant women with and without gestational diabetes mellitus (GDM). Method A total of 80 pregnant women participated in our study (which consisted of 40 patients with GDM, 40 participants as the control group). Myonectin and irisin levels were analyzed through the ELISA technique, in addition to metabolic parameters in the serum samples of the participants. Results It was found that the levels of irisin and myonectin were lower in the GDM group compared to the control group. Moreover, it was determined that the values of age (p<0.001), body mass index (p=0.001), gravida (p=0.001), parity (p = 0.016), fasting serum glucose (p=0.001), fasting serum insulin (p=0.007), postprandial serum glucose (p=0.006), HbA1c (p<0.001), HOMA-IR (p<0.001) were higher; HDL cholesterol (p<0.001) was lower. Insulin resistance was significantly higher in the GDM group. Conclusions Levels of myonectin and irisin were determined to be low in the GDM group. Our results have demonstrated that myonectin and irisin could play a role in the development of GDM and that irisin as well as myonectin could be a novel biomarker for GDM.

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Section: Discussionmentioning

confidence: 99%

Section: Gdmmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Circulating Myonectin and Irisin Levels in Gestational Diabetes Mellitus – A Case-control Study

Onat

2021

Z Geburtshilfe Neonatol

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“…There have been two studies assessing the levels of myonectin in PCOS patients, to the best of our knowledge [ 27 , 75 ]. In the study by Demur and Guler, myonectin levels were significantly lower in PCOS subjects, when compared to their BMI-matched controls.…”

Section: Myonectinmentioning

confidence: 99%

“…In the study by Demur and Guler, myonectin levels were significantly lower in PCOS subjects, when compared to their BMI-matched controls. Myonectin has exhibited inverse association with BMI, insulin resistance (measured using HOMA-IR, FPI), free androgen index (FAI), and triglycerides, while it showed a positive association with high-density lipoprotein cholesterol (HDL-C) [ 27 ]. Concordant results, in terms of myonectin concentration and the correlations were obtained by Zhang et al, in slightly larger groups (each containing 100 participants) [ 75 ].…”

Section: Myonectinmentioning

confidence: 99%

Review of Novel Potential Insulin Resistance Biomarkers in PCOS Patients—The Debate Is Still Open

Kruszewska

Laudy-Wiaderny²,

Kunicki

2022

IJERPH

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Research on proteins and peptides that play roles in metabolic regulation, which may be considered potential insulin resistance markers in some medical conditions, such as diabetes mellitus, obesity and polycystic ovarian syndrome (PCOS), has recently gained in interest. PCOS is a common endocrine disorder associated with hyperandrogenemia and failure of ovulation, which is often accompanied by metabolic abnormalities, including obesity, dyslipidemia, hyperinsulinemia, and insulin resistance. In this review, we focus on less commonly known peptides/proteins and investigate their role as potential biomarkers for insulin resistance in females affected by PCOS. We summarize studies comparing the serum fasting concentration of particular agents in PCOS individuals and healthy controls. Based on our analysis, we propose that, in the majority of studies, the levels of nesfastin-1, myonectin, omentin, neudesin were decreased in PCOS patients, while the levels of the other considered agents (e.g., preptin, gremlin-1, neuregulin-4, xenopsin-related peptide, xenin-25, and galectin-3) were increased. However, there also exist studies presenting contrary results; in particular, most data existing for lipocalin-2 are inconsistent. Therefore, further research is required to confirm those hypotheses, as well as to elucidate the involvement of these factors in PCOS-related metabolic complications.

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Diagnostic and predictive abilities of myokines in patients with heart failure

Berezin,

Berezina,

Hoppe

et al. 2024

Advances in Protein Chemistry and Structural Biology

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Association of decreased myonectin levels with metabolic and hormonal disturbance in polycystic ovary syndrome

Cited by 11 publications

References 16 publications

Circulating Myonectin and Irisin Levels in Gestational Diabetes Mellitus – A Case-control Study

Circulating Myonectin and Irisin Levels in Gestational Diabetes Mellitus – A Case-control Study

Review of Novel Potential Insulin Resistance Biomarkers in PCOS Patients—The Debate Is Still Open

Diagnostic and predictive abilities of myokines in patients with heart failure

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