Association of decreased sperm motility and increased seminal plasma IGF-I, IGF-II, IGFBP-2, and PSA levels in infertile men

Fu, Li; Yuen, Kevin C.J.; Tint, Aye Nyein; Hoffman, Andrew R.; Bongso, Ariff; Lee, Kok-Onn

doi:10.1007/s12020-021-02823-w

Cited by 8 publications

(4 citation statements)

References 54 publications

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“…SCc protects sperm through various paracrine factors. Among these factors, IGF-I can stabilize DNA by regulating spermatozoa maturation, which then increases sperm motility and count (22). These findings are consistent with previous studies.…”

Section: Real-time Pcr Analysissupporting

confidence: 93%

Sertoli cell-conditioned medium can improve blood-testis-barrier function and spermatogenesis in azoospermia mice induced by scrotal hyperthermia: An experimental study

Aghajanpour,

Soltani,

Afshar

et al. 2024

IJRM

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Background: An increase in the temperature of the testis is associated with damage to the epithelium of seminiferous tubules and disruption of sperm production. Objective: The current study aimed to investigate the effect of the Sertoli cell-conditioned medium (SCCM) on the blood-testis-barrier associated genes and spermatogenesis process following scrotal hyperthermia. Materials and Methods: In this experimental study, 40 adult NMRI mice (8 wk, 25–30 gr) were allocated into 4 groups: I) control, II) DMEM (10 μl Dulbecco’s Modified Eagle Medium), III) scrotal hyperthermia, and IV) scrotal hyperthermia+SCCM (10 μl SCCM). Hyperthermia was induced by placing the mice scrotum in water at 43°C for 20 min every other day for 10 days. Mice were treated every other day for 5 wk. Then the animals were euthanized, and the tails of epididymis were removed to analyze sperm parameters, testis were taken for stereological assessment, reactive oxygen spices and glutathione levels, and the expression of Ocln, Gja1, Cdh2, and Itgb1. Results: The results of sperm analysis indicated that SCCM-treated mice significantly increased sperm count and motility and reduced DNA fragmentation. In addition, histological and molecular findings showed that the volume of testicular tissue, the number of germ cells, the glutathione level, and the expression of Ocln, Gja1, Cdh2, and Itgb1 genes were significantly increased in the SCCM-treated mice. Conclusion: Findings suggest that growth factors of SCCM stimulate the proliferation and differentiation of germ cells through paracrine effects and upregulate the blood-testis-barrier-associated genes in mice subjected to scrotal hyperthermia. Key words: Testis, Sertoli cells, Culture media, Hyperthermia, Spermatogenesis.

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Section: Real-time Pcr Analysissupporting

confidence: 93%

Sertoli cell-conditioned medium can improve blood-testis-barrier function and spermatogenesis in azoospermia mice induced by scrotal hyperthermia: An experimental study

Aghajanpour,

Soltani,

Afshar

et al. 2024

IJRM

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“…In another study, Fu et al found significantly higher sperm IGF-1 level in the group with sperm motility disorders. A significant positive correlation was found between sperm count and sperm IGF-1 level [31]. In our study, differences were found in sperm parameters and GH/IGF-1 levels in serum and semen between individuals with acromegaly and healthy controls.…”

Section: Discussionsupporting

confidence: 52%

The Association Between Oxidative Stress and Sperm Parameters in Patients with Acromegaly

Sahin,

Cicek,

Kocaman

et al. 2024

Exp Clin Endocrinol Diabetes

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Objective Spermatozoa are susceptible to oxidative radicals when antioxidant defenses are inadequate. The extent to which oxidative radicals contribute to sperm damage in patients with acromegaly remains unclear. This study aimed to investigate and elucidate this relationship. Methods The overall status of oxidants and antioxidants in both seminal plasma and serum of patients with acromegaly compared to a control group of healthy individuals was investigated. In addition, sperm parameters, including important measures such as growth hormone and insulin-like growth factor-1 concentrations. Results Twenty-two patients with acromegaly with controlled disease and 14 healthy controls were included. The total oxidant status was significantly higher in the semen samples of the patients with acromegaly. A negative correlation was found between sperm total oxidant status and total sperm count and sperm concentration. Similarly, a negative correlation was found between the total sperm count and the sperm oxidative stress index. In individuals diagnosed with acromegaly, there was a statistically significant increase in sperm growth hormone levels. Conversely, the level of insulin-like growth factor 1 was significantly increased in the sperm of the control group, which consisted of healthy individuals. The correlation analysis revealed a significant relationship between venous total oxidant status and growth hormone levels in semen. Conclusion The elevated levels of reactive oxygen radicals in individuals with acromegaly suggest a possible link between oxidative stress and its effects on semen quality.

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“…FRMD3 was identified as a novel putative tumour suppressor gene that plays an important role in the origin and progression of lung cancer (Haase et al, 2007). High IGF2 gene expression may lead to decreased sperm motility (Fu et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Analysis of lncRNA and mRNA expression profiling in immature and mature DeZhou donkey (equine Taurus) testes

Yu¹,

Wang²,

Wang³

et al. 2023

Reprod Domestic Animals

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Testicular development and spermatogenesis are tightly regulated by the number of genes and noncoding genes, and mRNAs and lncRNAs play vital roles in regulating posttranscriptional gene expression. However, mRNAs and lncRNAs have not been systematically identified in the testes of donkeys. In this study, mRNA and lncRNA expression profiles in the testes of DeZhou donkeys between 2 months and 2 years of age were comprehensively analysed by RNA sequencing. We identified 56,605 lncRNAs and 61,857 mRNAs by gene expression analysis, and 21,845 lncRNAs (p < .05) and 14,109 mRNAs (p < .05) were differentially expressed in the immature (2‐month‐old, n = 3, noADGW) and mature (2‐year‐old, n = 3, ADGW) stages. In addition, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses revealed that the predicted target genes were enriched in the adherens junction, cell cycle, propanoate metabolism and cell adhesion molecule pathways. This study identified and analysed a comprehensive catalogue of lncRNAs and mRNAs in donkey testes, which provides a useful resource for further investigation of biological function in donkey lncRNAs.

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Association of decreased sperm motility and increased seminal plasma IGF-I, IGF-II, IGFBP-2, and PSA levels in infertile men

Cited by 8 publications

References 54 publications

Sertoli cell-conditioned medium can improve blood-testis-barrier function and spermatogenesis in azoospermia mice induced by scrotal hyperthermia: An experimental study

Sertoli cell-conditioned medium can improve blood-testis-barrier function and spermatogenesis in azoospermia mice induced by scrotal hyperthermia: An experimental study

The Association Between Oxidative Stress and Sperm Parameters in Patients with Acromegaly

Analysis of lncRNA and mRNA expression profiling in immature and mature DeZhou donkey (equine Taurus) testes

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