Association of decreases in PM2.5 levels due to the implementation of environmental protection policies with the incidence of obesity in adolescents: A prospective cohort study

Liang, Xiaohua; Liu, Fangchao; Liang, Fengchao; Ren, Yanling; Tang, Xian; Luo, Sheng‐Wei; Huang, Daochao; Feng, Wei

doi:10.1016/j.ecoenv.2022.114211

Cited by 9 publications

(3 citation statements)

References 81 publications

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“…Another study showed that there is a dose-response relationship between PM 2.5 exposure and childhood obesity, especially central obesity, suggesting that controlling ambient air pollution can prevent the occurrence of obesity in children and adolescents 42 . Finally, a prospective study from China 43 demonstrated that a reduction in PM 2.5 levels due to implementation of environmental protection policies led to a substantial decrease in adolescent obesity rates. Using GIS in this study made it possible to identify and illustrate the world regions and the specific countries with a high prevalence of adolescent obesity, air pollution by PM 2.5 , or both, such as Venezuela, Algeria, Libya, Saudi Arabia, Iraq, and the Oceania islands.…”

Section: Discussionmentioning

confidence: 99%

An Ecological Association Between Air Pollution and Adolescent Obesity Study

Treister-Goltzman

2024

J Occup Environ Med

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Objective The purposes of this study were to assess the association between exposure to particulate matter (PM2.5) and adolescent obesity, and to identify and visualize the world areas where the problems of adolescent obesity and air pollution by fine PM are more severe. Methods An ecological study, based on publicly available data from a WHO site. Results For each increase in air pollution there was an increase in the probability of being in the higher prevalence obesity group (OR = 1.18 (95% CI, 1.06-1.31)). High prevalence rates for both adolescent obesity and air pollution by PM2.5 were identified in several countries, including Venezuela, Algeria, Libya, Saudi Arabia, Iraq, and Oceania islands. Conclusions Efforts by local authorities and world organizations should be focused on the countries with the highest prevalence rates for both conditions.

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Section: Discussionmentioning

confidence: 99%

An Ecological Association Between Air Pollution and Adolescent Obesity Study

Treister-Goltzman

2024

J Occup Environ Med

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“…Meanwhile, the risk associated with PM2.5 was significantly higher in groups that were older or lived in urban areas. Another prospective cohort study suggested a negative correlation between decreasing PM2.5 concentrations and the prevalence of obesity in children and adolescents, suggesting that cleaning up airborne pollutants could prevent the development of obesity in these populations ( 36 ). Sara Fioravanti et al.…”

Section: Discussionmentioning

confidence: 99%

The causal relationship between air pollution, obesity, and COVID-19 risk: a large-scale genetic correlation study

Zhang,

Wen,

Wan

et al. 2023

Front. Endocrinol.

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ObjectiveObservational evidence reported that air pollution is a significant risk element for numerous health problems, such as obesity and coronavirus disease 2019 (COVID-19), but their causal relationship is currently unknown. Our objective was to probe the causal relationship between air pollution, obesity, and COVID-19 and to explore whether obesity mediates this association.MethodsWe obtained instrumental variables strongly correlated to air pollutants [PM2.5, nitrogen dioxide (NO2) and nitrogen oxides (NOx)], 9 obesity-related traits (abdominal subcutaneous adipose tissue volume, waist-to-hip ratio, body mass index, hip circumference, waist circumference, obesity class 1-3, visceral adipose tissue volume), and COVID-19 phenotypes (susceptibility, hospitalization, severity) from public genome-wide association studies. We used clinical and genetic data from different public biological databases and performed analysis by two-sample and two-step Mendelian randomization.ResultsPM2.5 genetically correlated with 5 obesity-related traits, which obesity class 1 was most affected (beta = 0.38, 95% CI = 0.11 - 0.65, p = 6.31E-3). NO2 genetically correlated with 3 obesity-related traits, which obesity class 1 was also most affected (beta = 0.33, 95% CI = 0.055 - 0.61, p = 1.90E-2). NOx genetically correlated with 7 obesity-related traits, which obesity class 3 was most affected (beta = 1.16, 95% CI = 0.42-1.90, p = 2.10E-3). Almost all the obesity-related traits genetically increased the risks for COVID-19 phenotypes. Among them, body mass index, waist circumference, hip circumference, waist-to-hip ratio, and obesity class 1 and 2 mediated the effects of air pollutants on COVID-19 risks (p < 0.05). However, no direct causal relationship was observed between air pollution and COVID-19.ConclusionOur study suggested that exposure to heavy air pollutants causally increased risks for obesity. Besides, obesity causally increased the risks for COVID-19 phenotypes. Attention needs to be paid to weight status for the population who suffer from heavy air pollution, as they are more likely to be susceptible and vulnerable to COVID-19.

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“…Recently, the relationships between components of PM2.5 and ischemic stroke have been investigated. Zhang et al reported that the association of ions were generally consistent for ischemic stroke and that polycyclic aromatic hydrocarbons (PAHs), especially indeno(1,2,3-cd)pyrene and benzo(b)fluoranthene, were predominantely associated with ischemic stroke [ 24 ]. PAHs upregulate CYP1A1 by an aryl hydrocarbon receptor (AhR)-dependent manner.…”

Section: Introductionmentioning

confidence: 99%

Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation

et al. 2023

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Background A recent epidemiological study showed that air pollution is closely involved in the prognosis of ischemic stroke. We and others have reported that microglial activation in ischemic stroke plays an important role in neuronal damage. In this study, we investigated the effects of urban aerosol exposure on neuroinflammation and the prognosis of ischemic stroke using a mouse photothrombotic model. Results When mice were intranasally exposed to CRM28, urban aerosols collected in Beijing, China, for 7 days, microglial activation was observed in the olfactory bulb and cerebral cortex. Mice exposed to CRM28 showed increased microglial activity and exacerbation of movement disorder after ischemic stroke induction. Administration of core particles stripped of attached chemicals from CRM28 by washing showed less microglial activation and suppression of movement disorder compared with CRM28-treated groups. CRM28 exposure did not affect the prognosis of ischemic stroke in null mice for aryl hydrocarbon receptor, a polycyclic aromatic hydrocarbon (PAH) receptor. Exposure to PM2.5 collected at Yokohama, Japan also exacerbated movement disorder after ischemic stroke. Conclusion Particle matter in the air is involved in neuroinflammation and aggravation of the prognosis of ischemic stroke; furthermore, PAHs in the particle matter could be responsible for the prognosis exacerbation.

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Association of decreases in PM2.5 levels due to the implementation of environmental protection policies with the incidence of obesity in adolescents: A prospective cohort study

Cited by 9 publications

References 81 publications

An Ecological Association Between Air Pollution and Adolescent Obesity Study

An Ecological Association Between Air Pollution and Adolescent Obesity Study

The causal relationship between air pollution, obesity, and COVID-19 risk: a large-scale genetic correlation study

Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation

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