Association of Deja vu With Cardiovascular Diseases

Rashid, Sarim; Khenhrani, Raja Ram; Devi, Sapna; Veer, Maha; Malik, Maria; Malik, Jahanzeb

doi:10.1016/j.cpcardiol.2023.101793

Cited by 1 publication

(1 citation statement)

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“…It also partially regulates blood Aβ hemodynamics ( 55 ). The protein that this gene codes for is also involved in the metabolism of lipoproteins, such as triglycerides and cholesterol, and this process aids in the development of atherosclerosis, a condition that is known to be a major cause of coronary artery disease ( 56 ).…”

Section: Discussionmentioning

confidence: 99%

Causal relationship between Alzheimer’s disease and unstable angina: a bidirectional Mendelian randomization analysis

Chen,

Ren,

2024

Front. Psychiatry

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BackgroundResearch from observational studies has demonstrated a link between Alzheimer’s disease (AD) and a higher risk of cardiovascular disease (CVD). Uncertainty surrounds the exact genetic cause of AD and coronary heart disease, particularly unstable angina (UA). Mendelian randomization (MR) analysis was used to examine the causal genetic link between AD and UA to evaluate the impact of AD on UA.MethodsThe purpose of the bidirectional MR analysis was to investigate the link between exposure and illness causation. Genetic instrumental variables for AD were obtained from European populations using genome-wide association studies (GWAS). The primary causal conclusions were obtained using the inverse variance weighted approach (IVW), and other sensitivity analysis techniques were employed. Sensitivity analyses were carried out to evaluate heterogeneity and horizontal pleiotropy to guarantee accurate MR results.ResultsAn elevated risk of UA was linked to genetically predicted AD (IVW: OR=3.439, 95% CI: 1.565-7.555, P=0.002). A substantial genetic relationship between UA and the risk of AD was not supported by any evidence in the reverse study (IVW: OR=0.998, 95% CI: 0.995-1.001, P=0.190). Various MR techniques produced consistent results. Sensitivity analysis revealed no discernible heterogeneity or horizontal pleiotropy.ConclusionsOne risk factor for UA that we found in our bidirectional Mendelian randomization trial was AD. This highlights the necessity of researching the underlying molecular mechanisms linked to AD and UA as well as the possibility of creating individualized treatment plans based on genetic data.

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Section: Discussionmentioning

confidence: 99%