Association of dental and periodontal status with bisphosphonate-related osteonecrosis of the jaws. A retrospective case controlled study

Kos, Marcin

doi:10.5114/aoms.2014.40738

Cited by 31 publications

(47 citation statements)

References 42 publications

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“…A retrospective case control study by Kos showed that the percentage of patients with deep teeth pockets was significantly higher among BRONJ cases (14). …”

Section: Discussionmentioning

confidence: 99%

A 5-year retrospective longitudinal study on the incidence and the risk factors of osteonecrosis of the jaws in patients treated with zoledronic acid for bone metastases from solid tumors

Manfrēdi

Mergoni²,

Goldoni³

et al. 2017

Med Oral

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BackgroundThe aim of this study was to evaluate the incidence and the risk factors of osteonecrosis of the jaw (ONJ) in a group of patients treated with zoledronic acid (ZA) for bone metastases from solid tumors and enrolled in a preventive dental program.Material and MethodsThis 5-year retrospective longitudinal study included all consecutive oncological patients who underwent at least one infusion with ZA between 2004 and 2011 for bone metastases due to solid neoplasms.ResultsOf the 156 patients enrolled in the study, 17 developed ONJ (10.89%). At the multivariate analysis, severe periodontal disease (P=0.025), tooth extraction (P<0.0001) and starting the preventive dental program after the beginning of ZA therapy (P=0.02) were the only factors which showed a significant association with the occurrence of ONJ.ConclusionsThis study demonstrated the importance of beginning dental prevention before zoledronic acid exposure in reducing ONJ occurrence, especially in the long term. The results of this research show that control of periodontal disease and an increase in the time between tooth extraction and the first ZA administration are recommended in order to reduce the risk of ONJ development. Key words:Osteonecrosis of the jaw, dental prevention, zoledronic acid, incidence.

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“…A retrospective case control study by Kos showed that the percentage of patients with deep teeth pockets was significantly higher among BRONJ cases (14). …”

Section: Discussionmentioning

confidence: 99%

A 5-year retrospective longitudinal study on the incidence and the risk factors of osteonecrosis of the jaws in patients treated with zoledronic acid for bone metastases from solid tumors

Manfrēdi

Mergoni²,

Goldoni³

et al. 2017

Med Oral

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“…All of the studies had been published since 2008. Six of the studies were based in Europe (two in the Germany, three in Italy, one in Greece and one in Spain), two in United States of America, one in Brazil, one in Japan and one in Australia …”

Section: Resultsmentioning

confidence: 99%

Association between periodontitis and medication‐related osteonecrosis of the jaw: A systematic review and meta‐analysis

Lorenzo-Pouso

Pérez‐Sayáns

Chamorro-Petronacci

et al. 2019

J Oral Pathology Medicine

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Consensus has yet to be reached about the prevention and treatment of medication‐related osteonecrosis of the jaw (MRONJ), which is a treatment sequela of several antiresorptive therapies and other pharmaceutical interventions. Several epidemiologic studies have identified periodontal disease (PD) as a risk factor for this outcome. Thus, the objective of this systematic review and meta‐analysis was to investigate this association and its magnitude. A systematic search in MEDLINE via PubMed, Scopus and ISI Web of Science, and a meta‐analysis were undertaken. Observational studies that gathered information regarding prefixed definitions for both outcomes were selected, and the relevant information was then extracted, and their risk of bias was evaluated using the Newcastle‐Ottawa Scale. The protocol of the study was registered on PROSPERO (CRD42019125646). The initial search yielded 757 eligible records, of which 12 were deemed adequate for inclusion (5 cohort studies and 7 case‐control studies). On a random‐effects meta‐analysis, the risk of PD in MRONJ‐affected sites compared with at‐risk non‐affected patients was significantly greater, with a risk ratio of 2.75 (95% CI: 1.67‐4.52). Nonetheless, from a pooled analysis of three standardized periodontal measures (ie plaque index, clinical attachment loss and probing depth) no significant results were obtained. MRONJ appears to be associated with an increase in prevalence of PD. The direction of this association, and the factors influencing it must be investigated using further prospective data, and likewise, the possibility for using periodontal therapy as a prevention strategy must be looked into. Periodontal screening needs to be made an indispensable requisite for clinicians in order to establish a correct multidisciplinary approach in MRONJ.

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“…When BRONJ progressed into the basal bone, pathologic fracture, pus discharge and cutaneous fistula could be formed. The incidence of the BRONJ has been reported as between 0 to 28% (13)(14)(15)(16)(17). The incidence of the BRONJ in oral bisphosphonates were reported as a minimal risk.…”

Section: Discussionmentioning

confidence: 99%

Fibula Free Flap for Mandibular Reconstruction using Simulation Surgery in Bisphosphonate related Osteonecrosis of the Jaw

Kim¹,

Hwang²,

Ahn³

2015

Journal of International Society for Simulation Surgery

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PurposeZZBisphophonate-related osteonecrosis of the jaw (BRONJ) is an emerging problem. Extensive osteonecrosis of the jaw needs free flap reconstruction. Free fibular flap is the most useful flap for maxilla-mandibular hard and soft tissue reconstruction. The advantages of fibular free flap are simultaneous soft and hard tissue reconstruction and placing implant in reconstructed mandible and maxilla. In this study, four consecutive BRONJ patients who underwent fibula free flap reconstruction using simulation surgery were reviewed. Materials and MethodsZZFour BRONJ patients who underwent free fibula reconstruction between May 2006 and September 2014 were included in this study. Male to female ratio was 1:3 and average age was 67.3 years old (62-70). All patients need mandibular bone reconstruction. Three patients suffered from osteoporosis and one male patient had multiple myeloma. Postoperative flap survival, functional reconstruction, esthetic results, food taking were evaluated. ResultsZZThree osseous flaps and one osteocutaneous flap were used. All the fibular flaps were survived and patients were recovered without complications. Oro-cutaneous fistula was resolved after operation. All patients were satisfied with the esthetic results. Patients reported improved solid food intake after operation with partial denture. One fully edentulous patient had semi-fluid diet after operation. ConclusionZZTreatment of the BRONJ is difficult due to lack of standard protocol. Fibular free flap using simulation surgery is the workhorse flap for mandibular hard and soft tissue reconstruction, especially in stage III BRONJ patient. In this study, functional and esthetic results were successful in all patients. Normal diet was possible with partial dentures. Key WordsZZ3D RP model ㆍSimulation surgery ㆍFibula free flap ㆍReconstruction ㆍBRONJ.

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Association of dental and periodontal status with bisphosphonate-related osteonecrosis of the jaws. A retrospective case controlled study

Cited by 31 publications

References 42 publications

A 5-year retrospective longitudinal study on the incidence and the risk factors of osteonecrosis of the jaws in patients treated with zoledronic acid for bone metastases from solid tumors

A 5-year retrospective longitudinal study on the incidence and the risk factors of osteonecrosis of the jaws in patients treated with zoledronic acid for bone metastases from solid tumors

Association between periodontitis and medication‐related osteonecrosis of the jaw: A systematic review and meta‐analysis

Fibula Free Flap for Mandibular Reconstruction using Simulation Surgery in Bisphosphonate related Osteonecrosis of the Jaw

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