Association of depressed postoperative lymphoproliferative responses to alloantigens with poor prognosis in patients with stage I lung cancer

Cannon, Grace B.; Dean, Jack H.; Rb, Herberman; Perlin, Elliott; Reid, James W.; Miller, Charles C.; Lang, Nicholas P.

doi:10.1002/ijc.2910250103

Cited by 29 publications

(13 citation statements)

References 22 publications

(22 reference statements)

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“…Defective cell-mediated immunity is known to corre late with the extent and spread of tumor in other human malignancies [4,6,13,20], This study confirms that spe cific immunologic mechanisms in patients with RCC remain well at an early tumor stage and reveal attenua tion with metastatic tumor spread. In our study all patients of the different subgroups showed similar levels of NK cell activity, which roughly correlated with the course of the RCC disease.…”

Section: Discussionsupporting

confidence: 72%

Natural Killer Cells in Patients with Renal Cell Cancer

Hofmann¹,

Lehmer²,

Reidel

et al. 1985

Urol Int

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Cytotoxic activity of natural killer (NK) cells in peripheral blood was studied in 60 patients with renal cell carcinoma (RCC) by means of a ⁵¹Cr release assay against K 562 cells, homologous and autologous RCC. All patients were tested prior to surgery and thereafter followed up for 1 year. Immunostimulating agents as interferon, levamisole, OMPI, and various bacterial extracts were tested for their boosting capacity on NK cells. Patients with localized tumor showed increased activity in comparison to age-matched controls, whereas NK cell activity and interferon-boosted activity in patients with advanced disease and tumor spread was decreased. Augmentation of NK activity could only be achieved by interferon, while application of levamisole, OMPI, and bacterial extracts resulted rather in suppression of cytotoxic activity.

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Section: Discussionsupporting

confidence: 72%

Natural Killer Cells in Patients with Renal Cell Cancer

Hofmann¹,

Lehmer²,

Reidel

et al. 1985

Urol Int

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“…In a previous study of Stage I lung cancer patients (Cannon et al, 19806), we have shown that depressed MLC reactivity was associated with a significantly shorter disease-free interval.…”

mentioning

confidence: 88%

Lymphoproliferative responses to autologous tumor extracts as prognostic indicators in patients with resected breast cancer

Cannon¹,

Dean²,

Herberman³

et al. 1981

Intl Journal of Cancer

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Patients with operable breast cancer were tested postoperatively to assess lymphoproliferative responses. Patients with lymphocytes capable of recognizing and proliferating in response to autologous tumor extracts had a significantly longer disease-free interval than those with a low response to their autologous extract. In this group of patients, immunological responses to autologous tumors predicted subsequent clinical course better than pathological evaluation based on tumor presence in axillary lymph nodes. Low or negative reactivity to autologous tumor often was not accompanied by a general, impaired ability to respond in LP assays. In fact, patients with low autologous tumor response and normal MLC were at particularly high risk for recurrence.

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“…The data for PHA and MLC responses were expressed as a relative proliferation index (RPI), which is a ratio of the net counts/min (CPM) (CPM in experimental group -CPM in unstimulated control) of a test individual to the mean net CPM in three or more normal individuals tested simultaneously [3]. Depressed or normal responses were determined from cut-off values (< 0.61 for PHA and <_ 0.50 for MLC) set at the lower tenth percentile of a large number (> 1,000) of normal individuals tested in our laboratory [1,3].…”

Section: Assays Rosettes With Sheep Erythrocytes (E) Total Rosette-fmentioning

confidence: 99%