Association of depressive disorder with biochemical and anthropometric indices in adult men and women

Abstract

Depression is a common psychiatric disorder. Although many risk factors for depression have been reported, the associations of biochemical and anthropometric indices with depressive disorder remain unclear. The objective of this study was to assess whether there are significant associations of depressive disorder with biochemical and obesity indices. This study was based on data from the Korea National Health and Nutrition Examination Survey from 2007 to 2018, and logistic regression was performed to examine the association of depression with biochemical and obesity indices. A total of 33,993 subjects were included in the analyses. Study subjects consisted of 13,178 men in the control group (mean age of 51.12 years), 509 men in the depression group (53.67), 18,279 women in the control group (50.5), and 2027 women in the depression group (55.39). Among men, the depression group was significantly more likely to have a lower height and weight than the control group. Compared to the control group, the depression group was more likely to have higher triglyceride levels and tended to have lower hematocrit and blood urea nitrogen (BUN) levels. Among women, the depression group was more likely to have higher triglyceride, aspartate aminotransferase (AST), BUN, and creatinine levels and lower high-density lipoprotein cholesterol (HDL-C), hematocrit, and red blood cell counts. Several biochemical and anthropometric indices used in this study were associated with depressive disorder, but these associations may differ according to sex.

Older Women Who Practiced Physical Exercises before the COVID-19 Pandemic Present Metabolic Alterations and Worsened Functional Physical Capacity after One Year of Social Isolation

“…We also observed significant negative correlations between circulating urea levels and triglycerides or the TG/HDL ratio in the post-COVID-19 pandemic period. Individuals with depressive disorders showed not only elevated triglyceride levels but also a decrease in urea levels [ 49 ]. Although we cannot confirm, this finding suggests that some volunteers enrolled in the present study may have developed depressive symptoms during the social isolation period imposed in response to the COVID-19 pandemic; for example, Sepúlveda-Loyola et al reported a significant association between vulnerability and depressive symptoms during the social isolation imposed in response to the COVID-19 pandemic [ 26 ].…”

Nutrition, Epigenetics, and Major Depressive Disorder: Understanding the Connection

“…Furthermore, to assess concretely nutritional deficiencies, questionnaires about food intake and biochemical markers measurements are the norm. Metabolic parameters include low hematocrit, low high-density lipoprotein cholesterol (HDL-C), and high triglyceride levels in patients with depression ( 76 ). More precisely and above mentioned, concrete groups of essential micronutrients are often much lower in these patients.…”

Associations between urea nitrogen and risk of depression among subjects with and without type 2 diabetes: A nationwide population-based study

“…In a mouse model simulating CKD, experiments confirmed the above, indicating that chronic accumulation of urea causes β-cell dysfunction in CKD patients and that urea is responsible for reduced insulin sensitivity and defective insulin secretion ( 22 , 23 ). However, in several other studies, BUN and depression risk were negatively correlated, demonstrated in the Korean and Chinese populations respectively ( 24 , 25 ).…”