Association of dermatoses with duration and quantum of alcohol intake: A comparative cross-sectional study

Shukla, Pankaj; Nayak, Roopa P; Kothari, Preeti; Gupta, Aayush

doi:10.4103/ijd.ijd_348_16

Cited by 6 publications

(21 citation statements)

References 16 publications

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“…Chronic alcohol use is linked to a variety of skin conditions and the earliest clinical manifestations of alcohol use disorder are cutaneous [46]. There is a known association between regular alcohol use and SD, likely resulting from immunosuppression, malnutrition, poor hygiene, vitamin B deficiency, and other confounders [17,18,19,20]. One study did not find an association between regular alcohol use and SD adjusted for possible confounders, including demographic, socioeconomic, and medical information, calling into doubt conclusions drawn from unadjusted studies [10].…”

Section: Discussionmentioning

confidence: 99%

“…They found an inverse relationship between SD prevalence and duration of alcohol intake, SD prevalence is inversely related to the duration of alcohol intake, meaning those with fewer years of alcohol use (P < .001) were more likely to have SD [17]. when looking at an older population [17].…”

Section: Alcoholmentioning

confidence: 98%

Section: Alcoholmentioning

confidence: 99%

“…Numerous studies found significant associations between regular alcohol use and an increased prevalence of SD [17,18,19,20] Further, increased alcohol consumption is associated with a greater risk of SD flares (OR = 5.4, P = .08) [20]. Sharma et al evaluated quantity of alcohol consumed in a week, duration of alcohol intake, and SD duration in 196 males, who reported drinking ≥200 mL of pure alcohol weekly, that were referred for a dermatologic consult [17]. They found an inverse relationship between SD prevalence and duration of alcohol intake, SD prevalence is inversely related to the duration of alcohol intake, meaning those with fewer years of alcohol use (P < .001) were more likely to have SD [17].…”

Section: Alcoholmentioning

confidence: 99%

“…Sharma et al evaluated quantity of alcohol consumed in a week, duration of alcohol intake, and SD duration in 196 males, who reported drinking ≥200 mL of pure alcohol weekly, that were referred for a dermatologic consult [17]. They found an inverse relationship between SD prevalence and duration of alcohol intake, SD prevalence is inversely related to the duration of alcohol intake, meaning those with fewer years of alcohol use (P < .001) were more likely to have SD [17]. when looking at an older population [17].…”

Section: Alcoholmentioning

confidence: 99%

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Nutrition, Obesity, and Seborrheic Dermatitis: Systematic Review

Woolhiser,

Keime,

Patel

et al. 2024

JMIR Dermatol

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Background: Pathogenesis of seborrheic dermatitis (SD) involves lipid secretion by sebaceous glands, Malassezia colonization and an inflammatory response with skin barrier disruption. Each of these pathways could be modulated by diet, obesity, and nutritional supplements. Current treatment options provide only temporary control of the condition; thus, it is essential to recognize modifiable lifestyle factors that may play a role in determining disease severity.Objective: To summarize published evidence on diet, nutritional supplements, alcohol, obesity, and micronutrients in SD patients and to provide useful insights into areas of further research. Methods:A literature search of Scopus, PubMed, and Medline (OVID interface) for English language articles published between 1993-2023 was conducted on 16th April 2023. Case-control studies, cohort studies, and randomized controlled trials with 5 or more subjects conducted on adult participants (>14 years) were included, case reports, case series and review papers were excluded.Results: 13 studies, eight case-control, three cross-sectional and two randomized control trials, involving 13,906 patients were included. SD patients had significantly increased copper, manganese, iron, calcium, and magnesium concentrations and significantly lower serum zinc and vitamin D and E concentrations compared to controls. Adherence to the Western Diet was associated with a higher risk for SD in female patients and an increased consumption of fruit was associated with a lower risk of SD in all patients. The prebiotic Triphala improved patient satisfaction and decreased scalp sebum levels over eight weeks. Most studies find associations between regular alcohol use and SD but the association with BMI and obesity on SD severity and prevalence is mixed. Conclusions:This review sheds light on specific promising areas of research that require further study, including the need for interventional studies evaluating serum zinc, vitamin D, and vitamin E supplementation for SD. The negative consequences of a western diet, alcohol use, and obesity, and the benefits of fruit consumption are well known; however, to fully understand their specific relationships to SD, further cohort or interventional studies are needed. Clinical Trial: This protocol was registered and can be accessed at Prospero with the registration number CRD42023417768.

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Section: Discussionmentioning

confidence: 99%

Section: Alcoholmentioning

confidence: 98%

Section: Alcoholmentioning

confidence: 99%

Section: Alcoholmentioning

confidence: 99%

Section: Alcoholmentioning

confidence: 99%

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Nutrition, Obesity, and Seborrheic Dermatitis: Systematic Review

Woolhiser,

Keime,

Patel

et al. 2024

JMIR Dermatol

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Correlation between cigarette smoking and alcohol consumption and Rosacea: A two‐sample Mendelian randomization study

Wang,

Zhang

2024

Skin Research and Technology

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BackgroundControversy persists regarding the causal relationship between Cigarette smoking, alcohol consumption, and Rosacea. This paper employs the Mendelian randomization (MR) method to elucidate the correlation between Cigarette smoking, alcohol consumption, and Rosacea. The aim is to contribute valuable insights to aid in the prevention and early treatment of Rosacea.MethodSummary datasets for cigarette smoking parameters (Cigarettes smoked per day, Smoking status: Previous, smoking status: Current) and alcohol consumption (Alcoholic drinks per week) were selected alongside data for Rosacea from genome‐wide association studies (GWAS). The Two‐sample MR method was employed to analyze the correlation between cigarette smoking, alcohol consumption, and Rosacea. Various MR analysis methods, including inverse variance weighting (IVW), MR‐Egger, Simple Mode, Weighted Mode, and Weighted Median, were chosen. IVW served as the primary analysis method.ResultsThe results indicate a significant negative association between Cigarettes smoked per day and Rosacea. Moreover, a significant positive correlation was observed between Smoking status: Previous and Rosacea. However, no significant associations were found between Smoking status: Current, Alcoholic drinks per week, and Rosacea.ConclusionThis study provides further clarity on the association between cigarette smoking, drinking, and Rosacea through a two‐sample MR analysis. Notably, the number of cigarettes smoked per day appears to be associated with a reduced incidence of Rosacea, while cigarette smoking cessation may increase the risk. Surprisingly, alcohol consumption does not emerge as a significant risk factor for Rosacea. These findings contribute to a nuanced understanding of the complex relationship between lifestyle factors and the occurrence of Rosacea, offering potential insights for preventive measures and early intervention.

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Nutrition, Obesity, and Seborrheic Dermatitis: Systematic Review (Preprint)

Weber¹,

Adelman²,

Woolhiser³

et al. 2023

Preprint

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BACKGROUND Pathogenesis of seborrheic dermatitis (SD) involves lipid secretion by sebaceous glands, Malassezia colonization and an inflammatory response with skin barrier disruption. Each of these pathways could be modulated by diet, obesity, and nutritional supplements. Current treatment options provide only temporary control of the condition; thus, it is essential to recognize modifiable lifestyle factors that may play a role in determining disease severity. OBJECTIVE To summarize published evidence on diet, nutritional supplements, alcohol, obesity, and micronutrients in SD patients and to provide useful insights into areas of further research. METHODS A literature search of Scopus, PubMed, and Medline (OVID interface) for English language articles published between 1993-2023 was conducted on 16th April 2023. Case-control studies, cohort studies, and randomized controlled trials with 5 or more subjects conducted on adult participants (>14 years) were included, case reports, case series and review papers were excluded. RESULTS 13 studies, eight case-control, three cross-sectional and two randomized control trials, involving 13,906 patients were included. SD patients had significantly increased copper, manganese, iron, calcium, and magnesium concentrations and significantly lower serum zinc and vitamin D and E concentrations compared to controls. Adherence to the Western Diet was associated with a higher risk for SD in female patients and an increased consumption of fruit was associated with a lower risk of SD in all patients. The prebiotic Triphala improved patient satisfaction and decreased scalp sebum levels over eight weeks. Most studies find associations between regular alcohol use and SD but the association with BMI and obesity on SD severity and prevalence is mixed. CONCLUSIONS This review sheds light on specific promising areas of research that require further study, including the need for interventional studies evaluating serum zinc, vitamin D, and vitamin E supplementation for SD. The negative consequences of a western diet, alcohol use, and obesity, and the benefits of fruit consumption are well known; however, to fully understand their specific relationships to SD, further cohort or interventional studies are needed. CLINICALTRIAL This protocol was registered and can be accessed at Prospero with the registration number CRD42023417768.

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Association of dermatoses with duration and quantum of alcohol intake: A comparative cross-sectional study

Cited by 6 publications

References 16 publications

Nutrition, Obesity, and Seborrheic Dermatitis: Systematic Review

Nutrition, Obesity, and Seborrheic Dermatitis: Systematic Review

Correlation between cigarette smoking and alcohol consumption and Rosacea: A two‐sample Mendelian randomization study

Nutrition, Obesity, and Seborrheic Dermatitis: Systematic Review (Preprint)

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