Product modeling has been applied in product engineering with success for geometric representation. With the application of multidisciplinary analysis, application-driven models need specific knowledge and time-consuming adjustment work based on the geometric model. This paper proposes a novel modeling technology named computer-aided design-supporting-simulation (CADSS) to generate multiphysics domain models to support multidisciplinary design optimization processes. Multiphysics model representation was analyzed to verify gaps among different domain models’ parameters. Therefore, multiphysics domain model architecture was integrated by optimization model, design model, and simulation model in consideration of domain model’s parameters. Besides, CADSS uses requirement space, domain knowledge, and software technology to describe the multidisciplinary model’s parameters and its transition. Depending on the domain requirements, the CADSS system extracts the required knowledge by decomposing product functions and then embeds the domain knowledge into functional features using software technology. This research aims to effectively complete the design cycle and improve the design quality by providing a consistent and concurrent modeling environment to generate an adaptable model for multiphysics simulation. This system is demonstrated by modeling turbine blade design with multiphysics simulations including computational fluid dynamics (CFD), conjugate heat transfer (CHT), and finite element analysis (FEA). Moreover, the blade multiphysics simulation model is validated by the optimization design of the film hole. The results show that the high-fidelity multiphysics simulation model generated through CADSS can be adapted to subsequent simulations.