Association of diabetes mellitus and chronic hepatitis C virus infection

BALIK, İsmail; Yılmaz, Nisbet; Türkçapar, Nuran; Yaşa, Hadi

doi:10.1002/hep.510300225

Cited by 8 publications

(7 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding was consistent with a previous study in which the HBV infection group had a lower prevalence of CKD (14.3%) than an HCV infection group (22.1%) and HBV/HCV co-infection group (17.2%) 8 . (3) The HCV infection group had the highest prevalence of diabetes (10.8%), which is consistent with several studies, showing that the prevalence of diabetes mellitus was significantly greater in patients with HCV infection 18–20 . Although the underlying mechanisms need to be elucidated, it appears that dysregulation of cytokines, intracellular oxidative stress, suppression of insulin downstream signaling, modulation of incretins, and pancreatic β-cell dysfunction are contributing factors 21–23 .In the present study, multivariate logistic regression analysis revealed that age >60 years, female gender, diabetes, lower TBIL, higher triglycerides, and higher total cholesterol were significant independent risk factors associated with the development of CKD, and these findings were consistent with other studies 24,25 .…”

Section: Discussionsupporting

confidence: 89%

Association of Hepatitis C and B Virus Infection with CKD and Impact of Hepatitis C Treatment on CKD

Zhang

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Hepatitis C virus (HCV) infection greatly increases the risk of nephropathy. In this observational study, we aimed to explore the relationship between viral hepatitis infection and chronic kidney disease (CKD), identify risk factors, and determine the effect of antiviral treatment on CKD in Chinese patients with chronic HCV infection. A total of 2,435 study subjects were enrolled and divided into four groups: the HCV infection, HBV infection, HBV and HCV co-infection, and uninfected control groups. Of these, 207 patients with chronic hepatitis C (CHC) were given standard dual therapy [subcutaneous injection of recombinant interferon (IFN)-α2b and oral ribavirin (RBV)] for 48 weeks. We found that the prevalence of CKD gradually increased with age in all groups and was significantly increased in patients 60 years or older. Multivariate logistic regression analyses showed that persistent HCV infection was significantly associated with CKD [odds ratio (OR), 1.33; 95% confidence interval (CI), 1.06–1.66; P = 0.013], whereas there was no significant link between CKD and spontaneous HCV clearance (OR, 1.23; 95% CI, 0.79–1.90; P = 0.364), HBV infection (OR, 0.73; 95% CI, 0.44–1.19; P = 0.201), or HBV/HCV co-infection (OR, 1.40; 95% CI, 0.81–2.40; P = 0.234). Notably, after anti-HCV therapy, the serum creatinine concentration was significantly decreased (76.0, 75.5–79.4 μmol/L) from the pretreatment level (95.0, 93.0–97.2 μmol/L), both in patients who showed an end of treatment virological response (ETVR) and those who did not (P < 0.001). Also, in both the ETVR and non-ETVR groups, the percentages of patients with an estimated glomerular filtration rate (eGFR) ≥90 ml/min/1.73 m2 increased significantly (P < 0.001), whereas the percentages of those with an eGFR <60 ml/min/1.73 m2 significantly decreased (P < 0.001). In conclusion, persistent HCV infection was independently associated with CKD, and antiviral treatment with IFN plus RBV can improve renal function and reverse CKD in HCV-infected patients.

show abstract

Section: Discussionsupporting

confidence: 89%

Association of Hepatitis C and B Virus Infection with CKD and Impact of Hepatitis C Treatment on CKD

Zhang

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Diabetes mellitus was present in 13% of our chronic viral hepatitis patients without significant difference between those with chronic hepatitis B or C. This is in contrast to previous reports suggesting that the prevalence of diabetes is higher in patients with HCV than HBV related chronic liver disease [11,13,14,32]. However, data among the several studies cannot be easily compared, as patient populations differed in age and presence or severity of cirrhosis, which are all very important factors associated with the risk of diabetes [11,[13][14][15].…”

Section: Discussioncontrasting

confidence: 82%

Diabetes mellitus in chronic hepatitis B and C: prevalence and potential association with the extent of liver fibrosis

Papatheodoridis¹,

Chrysanthos²,

Savvas³

et al. 2005

Journal of Viral Hepatitis

111

103

View full text Add to dashboard Cite

Diabetes mellitus has been reported to have an increased prevalence and to be associated with more severe fibrosis in patients with chronic hepatitis C. We evaluated the prevalence of diabetes mellitus in patients with chronic hepatitis B or C as well as the possible association between presence of diabetes and extent of liver fibrosis. In total, 434 consecutive patients with histologically documented hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (n = 174) or chronic hepatitis C (n = 260) were studied. The relationships of diabetes and epidemiological, somatomorphic, laboratory and histological patient characteristics were evaluated. Liver histological lesions were blindly evaluated according to the Ishak's classification. Diabetes was present in 58 (13%) patients, without any difference between those with chronic hepatitis B (14%) or C (13%). Diabetes was observed significantly less frequently in patients with fibrosis score 0-2 (7.7%) than 3-4 (10.4%) than 5-6 (29.2%) (P < 0.001). The presence of diabetes was independently associated with higher gamma-glutamyl-transpeptidase (GGT) levels and more severe fibrosis or presence of cirrhosis (P < 0.001) as well as with presence of hepatic steatosis and increased serum triglycerides levels (P < 0.02). In the noncirrhotic patients, diabetes was significantly associated with older age and higher GGT levels, but not with the extent of fibrosis. In conclusion, diabetes mellitus is observed in more than 10% of patients with either HBeAg-negative chronic hepatitis B or chronic hepatitis C. The presence of diabetes is strongly associated with more severe liver fibrosis, but such an association may be related to the high prevalence of diabetes in patients with cirrhosis.

show abstract

“…Alterations in carbohydrate metabolism are frequent in patients with cirrhosis 4, 5. In addition, previous reports have suggested an association between diabetes and HCV infection,6–9 although to our knowledge this remains controversial 10, 11. According to the criteria of National Diabetes Data Group,12 the prevalence of diabetes mellitus is higher in patients with cirrhosis than in those with chronic hepatitis, and in patients with cirrhosis the risk of diabetes depends on the stage of the disease 13.…”

mentioning

confidence: 99%

Impact of diabetes mellitus on the prognosis of patients with hepatocellular carcinoma

Toyoda

Kumada

Nakano

et al. 2001

Cancer

View full text Add to dashboard Cite

BACKGROUND The majority of patients with hepatocellular carcinoma (HCC) have coexisting cirrhosis or chronic hepatitis, often complicated by diabetes mellitus. In the current study, the authors evaluated the impact of diabetes mellitus on the prognosis of patients with HCC. METHODS Among 581 patients with HCC who had been diagnosed and treated between 1990 and 1999, survival was compared between those patients with and those patients without diabetes mellitus. The rate of disease recurrence after treatment also was analyzed. RESULTS Ninty‐two patients (15.8%) had diabetes mellitus. There was no significant difference with regard to patient characteristics (i.e., age, gender, or alcohol intake) or liver function between those patients with and those patients without diabetes mellitus. No differences were observed in survival between patients with diabetes mellitus and patients without it. Among the 195 patients with a solitary HCC lesion measuring ≦ 3 cm in greatest dimension, the survival of the 32 patients with diabetes mellitus was significantly poorer than that of the 163 patients without diabetes mellitus (P = 0.0273), despite no apparent difference in liver function between the 2 groups. On multivariate analysis, diabetes mellitus was found to be an independent factor predicting lower survival after treatment (P = 0.0077) among patients with a solitary HCC lesion measuring ≦ 3 cm in greatest dimension. No difference in the rate of recurrence was observed between the two groups in all the patients and in those patients with a solitary HCC lesion measuring ≦ 3 cm in greatest dimension. CONCLUSION The results of the current study indicated that the presence of diabetes mellitus worsens the prognosis of patients with a solitary HCC lesion measuring ≦ 3 cm in greatest dimension; it appears to impact prognosis in patients with HCC when HCC is treatable, based on the size and the number of lesions. However, diabetes mellitus did not appear to affect the prognosis in the general population of patients with HCC. Based on the current study data, diabetes mellitus does not appear to modify the progression of HCC and its recurrence after treatment, but it does appear to worsen the prognosis of patients with HCC by means of a rapid decline in remnant liver function caused by repeated treatment of HCC. Cancer 2001;91:957–63. © 2001 American Cancer Society.

show abstract

Association of diabetes mellitus and chronic hepatitis C virus infection

Cited by 8 publications

References 3 publications

Association of Hepatitis C and B Virus Infection with CKD and Impact of Hepatitis C Treatment on CKD

Association of Hepatitis C and B Virus Infection with CKD and Impact of Hepatitis C Treatment on CKD

Diabetes mellitus in chronic hepatitis B and C: prevalence and potential association with the extent of liver fibrosis

Impact of diabetes mellitus on the prognosis of patients with hepatocellular carcinoma

Contact Info

Product

Resources

About