Association of Diabetes Mellitus with a Combination of Vitamin D Deficiency and Arsenic Exposure in the Korean General Population: Analysis of 2008–2009 Korean National Health and Nutrition Examination Survey Data

Lee, Byung-Kook; Kim, Yangho

doi:10.1186/2052-4374-25-7

Cited by 12 publications

(12 citation statements)

References 34 publications

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“…Thus, the present study suggested that vitamin D status had no association with GDM preva- .4 nmol/L). Surprisingly, the levels in the first trimester were much lower than 40.363.4 nmol/L in 20-to 39-y-olds compared to levels reported by KHANES 2008KHANES -2009, and then they increased to more than the average levels of a Korean population (7). In the present study, low levels of serum 25-OH-D levels in the first trimester were related to a low intake of vitamin D. Daily vitamin D intake was calculated from food frequency tests that listed foods containing meaningful amounts of vitamin D. Frequencies of consuming each food and corresponding vitamin D intakes were calculated for each subject from these results using CAN-PRO (Korean Nutrient Society, Seoul, Korea).…”

Section: Discussioncontrasting

confidence: 57%

“…Serum levels of 25-hydroxyvitamin D (25-OH-D), a good measure of vitamin D status in humans, are inversely related to hypertension, diabetes, carotid atherosclerosis, myocardial infarction, congestive heart failure, stroke, microalbuminuria, and kidney dysfunction (3)(4)(5)(6). In a recent cross-sectional study on a Korean population, women less than 50 y old with more serum 25-OH-D (75 nmol/L) had a significantly lower prevalence of type 2 diabetes than those with less 25-OH-D (25 nmol/L) (7). In addition, serum 25-OH-D levels were significantly negatively associated with fasting insulin and homeostatic model assessment for insulin resistance (HOMA-IR) values in all participants.…”

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confidence: 99%

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Maternal Vitamin D Deficiency in Early Pregnancy Is Not Associated with Gestational Diabetes Mellitus Development or Pregnancy Outcomes in Korean Pregnant Women in a Prospective Study

Park

Yoon

Ryu

et al. 2014

J Nutr Sci Vitaminol

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Gestational diabetes mellitus (GDM) is a worldwide, growing complication during pregnancy (1). Many risk factors for GDM have been identified, including obesity prior to and during pregnancy, older maternal age, previous history of GDM, and family history of diabetes (1). However, these risk factors are not sufficient to predict GDM development in almost half of all cases (2). Hence, it is necessary to identify other risk factors, including potential nutritional factors.Vitamin D deficiency has recently been drawing the interest of medical researchers with its link to adverse outcomes of various diseases, other than bone diseases (3-6). Serum levels of 25-hydroxyvitamin D (25-OH-D), a good measure of vitamin D status in humans, are inversely related to hypertension, diabetes, carotid atherosclerosis, myocardial infarction, congestive heart failure, stroke, microalbuminuria, and kidney dysfunction (3-6). In a recent cross-sectional study on a Korean population, women less than 50 y old with more serum 25-OH-D (75 nmol/L) had a significantly lower prevalence of type 2 diabetes than those with less 25-OH-D (25 nmol/L) (7). In addition, serum 25-OH-D levels were significantly negatively associated with fasting insulin and homeostatic model assessment for insulin resistance (HOMA-IR) values in all participants. As GDM has a similar pathophysiology to type 2 diabetes (1), serum 25-OH-D levels in the first trimester may be a risk factor for GDM in Korean women. In previous studies, there is still some controversy about the association of vitamin D deficiency in the first trimester with adverse pregnancy outcomes such as GDM development, pre-eclampsia, infections, caesarean section, and fetal growth restric- Summary The association between vitamin D deficiency in the first trimester and GDM development remains controversial in various ethnicities. We prospectively assessed whether pregnant women with vitamin D deficiency during early pregnancy had an increased likelihood of GDM development or poor fetal growth or pregnancy outcomes compared to those with sufficient vitamin D levels. Serum 25-OH-D measurements and fetal ultrasonograms were carried out at 12-14, 20-22, and 32-34 wk in 523 pregnant women. Each woman was screened for GDM at 24-28 wk. There were no differences in serum 25-OH-D levels at 12-14 wk or 22-24 wk of pregnancy between GDM and non-GDM women after adjusting for maternal age, BMI at prepregnancy, BMI at first visit, BMI at GDM screening, gestational age at sampling, previous history of GDM, vitamin D intake, and seasonal variation in sampling. The risk of GDM, insulin resistance, and impaired b-cell function had no association with serum 25-OH-D levels in crude or adjusted logistic regression analysis. GDM was not associated with maternal serum 25-OH-D deficiency during the first trimester or fetal growth during the first and second trimesters. Pregnancy outcomes such as miscarriage, Apgar 1, Apgar 5 and birth weight were independent of maternal serum 25-OH-D levels during the first, second and third ...

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Section: Discussioncontrasting

confidence: 57%

mentioning

confidence: 99%

Maternal Vitamin D Deficiency in Early Pregnancy Is Not Associated with Gestational Diabetes Mellitus Development or Pregnancy Outcomes in Korean Pregnant Women in a Prospective Study

Park

Yoon

Ryu

et al. 2014

J Nutr Sci Vitaminol

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“…Epidemiological studies have reported an association between arsenic exposure and T2DM [ 87 , 90 , 92 , 94 , 170 ].…”

Section: Environmental Chemicalsmentioning

confidence: 99%

Can Exposure to Environmental Chemicals Increase the Risk of Diabetes Type 1 Development?

Bodin

Stene

Nygaard

2015

BioMed Research International

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Type 1 diabetes mellitus (T1DM) is an autoimmune disease, where destruction of beta-cells causes insulin deficiency. The incidence of T1DM has increased in the last decades and cannot entirely be explained by genetic predisposition. Several environmental factors are suggested to promote T1DM, like early childhood enteroviral infections and nutritional factors, but the evidence is inconclusive. Prenatal and early life exposure to environmental pollutants like phthalates, bisphenol A, perfluorinated compounds, PCBs, dioxins, toxicants, and air pollutants can have negative effects on the developing immune system, resulting in asthma-like symptoms and increased susceptibility to childhood infections. In this review the associations between environmental chemical exposure and T1DM development is summarized. Although information on environmental chemicals as possible triggers for T1DM is sparse, we conclude that it is plausible that environmental chemicals can contribute to T1DM development via impaired pancreatic beta-cell and immune-cell functions and immunomodulation. Several environmental factors and chemicals could act together to trigger T1DM development in genetically susceptible individuals, possibly via hormonal or epigenetic alterations. Further observational T1DM cohort studies and animal exposure experiments are encouraged.

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“…β -glucan mainly reduces insulin resistance to improve glucose metabolism [34]. Koreans have low levels of 25-OH-cholecalciferol in the blood, indicating vitamin D insufficiency that may affect glucose homeostasis with decreasing lean body mass [35,36]. Therefore, the combination of aronia, ginseng and mushroom may have a potent ant-diabetic activity.…”

Section: Discussionmentioning

confidence: 99%

Combination of Aronia, Red Ginseng and Shiitake Mushroom Potentiated Insulin Secretion and Reduced Insulin Resistance with Improving Gut Microbiome Dysbiosis in Insulin Deficient Type 2 Diabetic Rats

Yang¹,

Kim²,

Kwon³

et al. 2018

Preprint

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The combination of freeze-dried aronia, red ginseng, ultraviolet-irradiated shiitake mushroom and natokinase (AGM; 3.4: 4.1: 2.4: 0.1) was examined to evaluate its effects on insulin resistance, insulin secretion and gut microbiome in a non-obese type 2 diabetic animal model. Pancreatectomized (Px) rats were provided high fat diets supplemented with either of 1) 0.5 g AGM (AGM-L), 2) 1 g AGM (AGM-H), 3) 1 g dextrin (control), or 4) 1g dextrin with 120 mg metformin (positive-control) per kg body weight for 12 weeks. AGM (1 g) contained 6.22 mg cyanidin-3-galactose, 2.5 mg ginsenoside Rg3 and 0.6 mg β-glucan. Px rats had decreased bone mineral density in the lumbar spine and femur and lean body mass in the hip and leg compared to the normal-control and AGM-L and AGM-H prevented the decrease. Visceral fat mass was lower in the control group than the normal-control group and its decrease was smaller by AGM-L and AGM-H. HOMA-IR was lower in descending order of the control, positive-control, AGM-L, AGM-H and normal-control groups. Glucose tolerance was deteriorated in the control group and it was improved by AGM-L and AGM-H more than in the positive-control group.Glucose tolerance is associated with insulin resistance and insulin secretion. Insulin tolerance indicated insulin resistance was highly impaired in diabetic rats, but it was improved in the ascending order of the positive-control, AGM-L and AGM-H. Insulin secretion capacity, measured by hyperglycemic clamp, was much lower in the control group than the normalcontrol group and it was improved in the ascending order of the positive-control, AGM-L and AGM-H. Diabetes modulated the composition of gut microbiome and AMG prevented the modulation of gut microbiome. In conclusion, AGM improved glucose metabolism by potentiating insulin secretion and reducing insulin resistance in insulin deficient type 2 diabetic rats. The improvement of diabetic status alleviated body composition changes and prevented changes of gut microbiome composition.Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted:

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Association of Diabetes Mellitus with a Combination of Vitamin D Deficiency and Arsenic Exposure in the Korean General Population: Analysis of 2008–2009 Korean National Health and Nutrition Examination Survey Data

Cited by 12 publications

References 34 publications

Maternal Vitamin D Deficiency in Early Pregnancy Is Not Associated with Gestational Diabetes Mellitus Development or Pregnancy Outcomes in Korean Pregnant Women in a Prospective Study

Maternal Vitamin D Deficiency in Early Pregnancy Is Not Associated with Gestational Diabetes Mellitus Development or Pregnancy Outcomes in Korean Pregnant Women in a Prospective Study

Can Exposure to Environmental Chemicals Increase the Risk of Diabetes Type 1 Development?

Combination of Aronia, Red Ginseng and Shiitake Mushroom Potentiated Insulin Secretion and Reduced Insulin Resistance with Improving Gut Microbiome Dysbiosis in Insulin Deficient Type 2 Diabetic Rats

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