Association of dietary acid load with metabolic syndrome in overweight and obese women

Tangestani, Hadith; Emamat, Hadi; Tavakoli, Atefeh; Ghalandari, Hamid; Keshavarz, Seyed Ali; Yekaninejad, Mir Saeed; Mirzaei, Khadijeh

doi:10.1024/0300-9831/a000748

Cited by 5 publications

(12 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, higher NEAP was associated with higher fasting blood glucose 12 . Two other studies on Iranian women also showed no significant association between dietary acid load and MetS 11 , 28 , which is in accordance with our results. On the other hand, two other studies on Iranian elders and adolescents showed that higher NEAP was significantly associated with higher odds of MetS.…”

Section: Discussionsupporting

confidence: 93%

Higher dietary acid load is associated with an increased risk of metabolic syndrome

Seifi,

Rahimi,

Koochakpoor

et al. 2023

Sci Rep

View full text Add to dashboard Cite

There have been inconsistent reports regarding the association between dietary acid load and Metabolic Syndrome (MetS). We aimed to investigate the association between dietary acid load and MetS in an Iranian adult population. In this cross-sectional study, 1945 participants aged 35–65 years were recruited from MASHAD cohort study. Dietary intakes were assessed using a 24-h dietary recall. Diet-based acidity was assessed as the net endogenous acid production (NEAP), potential renal acid load (PRAL), and dietary acid load (DAL). To define MetS, the International Diabetes Federation (IDF) criteria were used. Multivariable logistic regression models were applied to determine the association between diet-based acid load scores and MetS. Participants' mean age and BMI were 47.13 ± 7.78 years and 27.57 ± 4.48 kg/m2, respectively. Around 57% of the population was female. Overall, 31.9% had MetS. According to the full-adjusted model, there was a significant association between higher quartiles of PRAL, NEAP, and DAL and MetS (Q4 PRAL; OR (95%CI) 1.42(1.05–1.91), Q4 NEAP; OR (95%CI) 1.48(1.11–1.98), Q4 DAL; OR (95%CI) 1.44(1.05–1.91)). This study showed a significant positive association between different dietary acid load indicators (PRAL, NEAP, and DAL) and odds of MetS among Iranian adults.

show abstract

Section: Discussionsupporting

confidence: 93%

Higher dietary acid load is associated with an increased risk of metabolic syndrome

Seifi,

Rahimi,

Koochakpoor

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…NAFLD is known as the hepatic manifestation of metabolic syndrome (Buzzetti et al, 2016). Previous studies have shown some mechanistic pathways for the relationship between PRAL and metabolic syndrome components (Mozaffari et al, 2019; Arisawa et al, 2020; Tangestani et al ., 2022). It is suggested that this relationship might be explained by the role of diet acidity in increasing blood pressure or hypertension risk (Krupp et al, 2012), or its indirect effects on the other CVD risk factors (Kucharska et al, 2018; Gæde et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…An unhealthy dietary pattern such as western diet increases acid load, which can induce chronic metabolic acidosis (Williams et al, 2016). Recent studies considered the acid–base imbalance as a risk factor for metabolic disorders and all-cause mortality (Fagherazzi et al, 2014; Akter et al, 2016a; Emamat et al ., 2018b; Hejazi et al, 2021; Tangestani et al ., 2022).…”

Section: Introductionmentioning

confidence: 99%

The association between dietary acid load and odds of non-alcoholic fatty liver disease: A case-control study

Emamat

Farhadnejad

Teymoori³

et al. 2022

Nutr Health

Self Cite

View full text Add to dashboard Cite

Background: Data on the association between dietary acid load and non-alcoholic fatty liver disease (NAFLD) are scarce and controversial. Aim: This study aimed to assess the association between dietary acid-base loads and odds of NAFLD. Methods: In the current study, 196 cases of NAFLD (proven by a gastroenterologist using Fibroscan) and 803 age-matched controls were enrolled from the same clinic. Dietary intakes of patients with NAFLD and controls without hepatic steatosis were evaluated using a validated food frequency questionnaire. Dietary acid load was estimated using the validated potential renal acid load (PRAL) algorithm. Multivariable logistic regression model was used to estimate the odds of NAFLD across quintiles of PRAL. Results: The mean ± SD age of the study population (43% male) was 43.28 ± 14.02 years. The mean ± SD of PRAL was −1.90 ± 7.12 for all participants. After adjustment for all known confounders, subjects in the third quintile of PRAL (nearly with neutral PRAL) had a 54% lower odds of NAFLD compared with those in the lowest quintiles of the PRAL [(OR: 0.46; 95%CI: 0.24–0.89), (P = 0.021)]. However, the odds of NAFLD in the highest quintiles of PRAL was not different in comparison to the lowest quintiles (OR: 0.90; 95%CI: 0.41–1.57). Conclusion: In conclusion, our results have shown a modest U shaped relationship between PRAL and NAFLD. Further studies with acid-base biomarkers are needed to confirm the role of dietary acid load in the development of NAFLD and its potential mechanisms.

show abstract

“…Moreover, another cross-sectional study of 371 Iranian women (20-50 years old) revealed no significant association between DAL and MetS [ 12 ]. Research by Tangestani et al did not reveal a statistically significant association between PRAL score and MetS in 246 Iranian women with overweight or obesity [ 16 ]. However, two Japanese cross-sectional studies contradict these findings [ 13 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Given the inconsistent results of previous studies on the association between dietary acid load (DAL) and MetS [ 11 - 16 ] and the different assumptions on the direction of this association, the present study aimed to examine the association between DAL and MetS and its components in a large sample of Iranian adults.…”

Section: Introductionmentioning

confidence: 97%

Association of Dietary Acid Load With Metabolic Syndrome and Its Components in Iranian Adults: A Cross-Sectional Study

Rajaie,

Homayounfar,

Khayyatzadeh

et al. 2023

Cureus

View full text Add to dashboard Cite

Introduction Metabolic syndrome (MetS) remains one of the leading health challenges worldwide. A combination of genetic and environmental factors has been implicated in the etiology of MetS. Diet is a changeable environmental risk factor, and dietary modifications could significantly reduce the incidence and mortality of numerous diseases, including MetS. Certain dietary factors may contribute to MetS by affecting the acid-base balance within the body. This study examined the association of dietary acid load (DAL) with MetS and its components in Iranian adults. Materials and methods This cross-sectional study was conducted in 2022 on 6356 Iranian adults aged 35-70 years. Potential renal acid load (PRAL) and net endogenous acid production (NEAP) as two indicators of DAL were calculated based on nutrient intake data from validated food frequency questionnaires. MetS and its components were defined according to the Adult Treatment Panel III criteria. Logistic regression analysis was used to explore the associations between DAL and MetS and its components. Age, energy intake, physical activity, education, marital status, home ownership, socioeconomic status, history of obesity-related disease, and calcium supplements were included in model I. Further adjustment in model II was made for body mass index. Results Higher NEAP scores were associated with increased odds of low high-density lipoprotein cholesterol (HDL-C) in the crude model (OR: 1.26, 95% CI: 1.01-2.56, p trend = 0.06) in women, which was confirmed in the adjusted models. In model I, women in the last quintile of NEAP had 54% greater odds of having hypertriglyceridemia compared to the first quintile (OR: 1.54, 95% CI: 1.007-2.36, p trend = 0.02). This association was still significant and even stronger after further adjustment for BMI (OR: 1.55, 95% CI: 1.01-2.40, p trend = 0.01). In addition, in model I, men in the fourth quintile of NEAP had 5.68-fold greater odds of hyperglycemia compared to the first quintile (OR: 5.68, 95% CI: 1.18-27.25, p trend = 0.11). Similar results were found in the fully adjusted model (OR: 5.89, 95% CI: 1.19-28.99, p trend = 0.54). Conclusion There was no significant association between DAL and MetS. DAL was positively associated with the odds of low HDL-C and hypertriglyceridemia in women. Moreover, moderate DAL (NEAP) was associated with an increased odds of hyperglycemia in men.

show abstract

Association of dietary acid load with metabolic syndrome in overweight and obese women

Cited by 5 publications

References 38 publications

Higher dietary acid load is associated with an increased risk of metabolic syndrome

Higher dietary acid load is associated with an increased risk of metabolic syndrome

The association between dietary acid load and odds of non-alcoholic fatty liver disease: A case-control study

Association of Dietary Acid Load With Metabolic Syndrome and Its Components in Iranian Adults: A Cross-Sectional Study

Contact Info

Product

Resources

About