Association of dietary fat intake and hepatocellular carcinoma among US adults

Moussa, Iman; Day, R. Sue; Li, Ruosha; Kaseb, Ahmed O.; Jalal, Prasun K.; Daniel, Carrie R.; Hatia, Rikita; Abdelhakeem, Ahmed; Rashid, Asif; Chun, Yun Shin; Li, Donghui; Hassan, Manal M.

doi:10.1002/cam4.4256

Cited by 11 publications

(5 citation statements)

References 62 publications

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“…Because Chinese participants, living in rural, consumed fewer animal fats, such as unprocessed red meat and processed meat; more vegetable oil dietary and fat from the plant, such as whole grains, nuts and legumes [37,38]. Moreover, dietary total fat intake up to 90g/ day has a signi cant protective effect on HCC; much higher than the protective effect of 47.50 g/ day dietary fat intake on liver function suggested by our RCS model [39]. It may be caused by Chinese and American difference in eating habits.…”

Section: Discussionmentioning

confidence: 81%

Association between macronutrient intake and liver dysfunction among tuberculosis patients in rural China

Liangjie

et al. 2023

Preprint

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Background Macronutrients play a vital role in liver dysfunction and affect the treatment and prognosis of tuberculosis. This study aimed to clarify the associations between macronutrients intakes or to energy percentages and liver dysfunction in tuberculosis patients. Methods In this cross-sectional study, 2695 active tuberculosis patients aged ≥ 18 years were included based on the data from local tuberculosis clinics in Linyi rural areas, China. Macronutrients intakes and to energy percentages were assessed by the 24-hour dietary recalls. The concentration of alanine transferase (ALT) or aspartate transaminase (AST) greater than 40 U/L was defined liver dysfunction. In addition, restricted cubic spline (RCS) was applied to determine the dose-response relationships. Results Among those who were male, or normal BMI, or consumed energy less than 1646.80 kcal/d, it was suggested both inverse associations between protein (47.30–78.80 g/d) or fat (> 20.30 g/d) intake and the risks of liver dysfunction in all models (all P-trend < 0.05). Moreover, the RCS model showed J-shaped associations between protein, fat intake, the fat or carbohydrate to energy percentages and the odds of liver dysfunction (the cut-off values = 70.69 g/d, 47.50 g/d, 22% and 69%, respectively, and all P-nonlinearity < 0.05). Conclusions An appropriate increase in dietary intakes of protein or fat might reduce liver dysfunction risk. However, intakes of more than 70.69 g/d for protein or 47.50 g/d for fat could increase the risk of liver dysfunction. Our study may provide a novel idea of alleviating liver dysfunction with nutritional improvement.

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Section: Discussionmentioning

confidence: 81%

Association between macronutrient intake and liver dysfunction among tuberculosis patients in rural China

Liangjie

et al. 2023

Preprint

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“…83,84 In a case-control study, intake of monounsaturated fatty acid (MUFA) and long-chain n-3 PUFA (EPA and DHA) was negatively associated with HCC risk, whereas intake of total PUFA and n-6 PUFA was positively associated with HCC risk. 85 Plasma concentrations of very-long-chain saturated fatty acids and n-3 PUFAs were lower in HCC patients as well as subjects with the PNPLA3 I148M risk genotype in South Texas Hispanics. 86 Rodent model-based studies have shown involvement of COX2 and other molecular pathways.…”

Section: Accepted Manuscriptmentioning

confidence: 90%

Hepatocellular Carcinoma Chemoprevention with Generic Agents

et al. 2022

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Liver cancer, mainly hepatocellular carcinoma (HCC), remains a major cause of cancer-related death worldwide. With the global epidemic of obesity, the major HCC etiologies have been dynamically shifting from viral to metabolic liver diseases. This change has made HCC prevention difficult with increasingly elusive at-risk populations as rational target for preventive interventions. Besides ongoing efforts to reduce obesity and metabolic disorders, chemoprevention in patients who already have metabolic liver diseases will have a significant impact on the poor HCC prognosis. Hepatitis B- and C-related HCC incidences have been substantially reduced by the new anti-virals, but HCC risk can persist over a decade even after successful viral treatment, highlighting the need for HCC-preventive measures also in these patients. Experimental and retrospective studies have suggested potential utility of generic agents such as lipophilic statins and aspirin for HCC chemoprevention given their well characterized safety profile, although anticipated efficacy may be modest. In this review, we overview recent clinical and translational studies of generic agents in the context of HCC chemoprevention under the contemporary HCC etiologies. We also discuss newly emerging approaches to overcome the challenges in clinical testing of the agents to facilitate their clinical translation.

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“…There was a positive association among US adults between hepatocellular carcinogenesis (HCC) and the total intake of PUFAs and ω-6 PUFAs. In contrast, the intake of long-chain omega-3 fatty acids and MUFAs was negatively associated with liver cancer [ 64 ]. ω-6 PUFAs could enhance the metastatic ability of gastric cancer cells through the COX-2/PGE2 signaling pathway, whereas ω-3 PUFAs serve to inhibit that ability through the COX-1/PGE3 signaling axis [ 65 ].…”

Section: Fatty Acids In the Diet And Their Relationship To Cancermentioning

confidence: 99%

CD36: The Bridge between Lipids and Tumors

Zhou,

Su,

et al. 2024

Molecules

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It has been found that the development of some cancers can be attributed to obesity, which is associated with the excessive intake of lipids. Cancer cells undergo metabolic reprogramming, shifting from utilizing glucose to fatty acids (FAs) for energy. CD36, a lipid transporter, is highly expressed in certain kinds of cancer cells. High expressions of CD36 in tumor cells triggers FA uptake and lipid accumulation, promoting rapid tumor growth and initiating metastasis. Meanwhile, immune cells in the tumor microenvironment overexpress CD36 and undergo metabolic reprogramming. CD36-mediated FA uptake leads to lipid accumulation and has immunosuppressive effects. This paper reviews the types of FAs associated with cancer, high expressions of CD36 that promote cancer development and progression, effects of CD36 on different immune cells in the tumor microenvironment, and the current status of CD36 as a therapeutic target for the treatment of tumors with high CD36 expression.

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Association of dietary fat intake and hepatocellular carcinoma among US adults

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 11 publications

References 62 publications

Association between macronutrient intake and liver dysfunction among tuberculosis patients in rural China

Association between macronutrient intake and liver dysfunction among tuberculosis patients in rural China

Hepatocellular Carcinoma Chemoprevention with Generic Agents

CD36: The Bridge between Lipids and Tumors

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