Association of dietary inflammatory index with chronic kidney disease and kidney stones in Iranian adults: A cross-sectional study within the Ravansar non-communicable diseases cohort

Moludi, Jalal; Fateh, Hawal Lateef; Pasdar, Yahya; Moradinazar, Mehdi; Sheikhi, Leila; Saber, Amir; Kamari, Negin; Bonyani, Mitra; Najafi, Farid; Dey, Priyankar

doi:10.3389/fnut.2022.955562

Cited by 16 publications

(8 citation statements)

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“…DII has been validated that it can reflect the levels of systemic inflammation and closely associated with the expressions of blood inflammatory markers, including C-reactive protein (CRP), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-10 ( 11 , 12 ). At present, DII has already been widely used to explore the roles of diet-induced inflammation in the occurrence and development of various diseases ( 13 – 15 ). Actually, our team previously conducted a cross-sectional study based on the NHANES to explore the association between DII and the risk of coronary heart disease (CHD).…”

Section: Introductionmentioning

confidence: 99%

The dietary inflammatory index and its association with the prevalence of hypertension: A cross-sectional study

et al. 2023

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AimsWe aim to investigate the association of the Dietary Inflammatory Index (DII) with the prevalence of hypertension in a large multiracial population in the United States.MethodsParticipants from the National Health and Nutrition Examination Survey (NHANES) (1999–2018) were included in this cross-sectional study. Dietary information was obtained and used to calculate DII. Blood pressures of participants were measured by experienced examiners. The NHANES used the method of “stratified multistage probability sampling,” and this study is a weight analysis following the NHANES analytic guidance. Weight logistic regression analysis was adopted to investigate the association of hypertension with DII. Least Absolute Shrinkage and Selection Operator (LASSO) regression was carried out to screen the most important dietary factors associated with the risk of hypertension. Moreover, a nomogram model based on key dietary factors was established; the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic power of the nomogram model for screening hypertension risk.ResultsA total of 45,023 participants were included in this study, representing 191 million residents in the United States. Participants with hypertension had an elevated DII compared with those without hypertension. Weight logistic regression showed that an increment of DII was strongly associated with hypertension after adjusting for confounding factors. The nomogram model, based on key dietary factors screened by LASSO regression, showed a favorable discriminatory power with an area under the curve (AUC) of 78.5% (95% CI: 78.5%–79.3%). Results of the sensitivity analysis excluding participants who received any drug treatment were consistent with those in the main analysis.ConclusionAn increment of DII is associated with the risk of hypertension. For better prevention and treatment of hypertension, more attention should be paid to controlling dietary inflammation.

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Section: Introductionmentioning

confidence: 99%

The dietary inflammatory index and its association with the prevalence of hypertension: A cross-sectional study

et al. 2023

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“…Previous studies have reported an association between DII and a variety of renal diseases including CKD and kidney stones by examining different epidemiologic methods and participants ( 10 , 12 , 27 , 30 ). A study based on 21,649 adult Americans reported the odds of prevalent CKD increased from 5.3% in the lowest to 9.3% in the highest DII quartile ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

Association between dietary inflammation index and albuminuria: results from the National Health and Nutrition Examination Survey

Ding,

Guo,

Zhang

et al. 2024

Front. Nutr.

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BackgroundThe Dietary Inflammation Index (DII) is a tool for evaluating the potential for dietary inflammation, and inflammation is a major cause of exacerbation in chronic kidney disease. Our study aimed to investigate the relationship between DII and albuminuria.MethodsData were obtained from the 2005–2018 National Health and Nutrition Examination Survey (NHANES) after excluding pregnant, minors, and missing data of urinary albumin-creatinine ratio (ACR), estimated glomerular filtration rate (eGFR), and DII were enrolled in our study. Albuminuria was defined as ACR > 30 mg/g. DII was calculated and divided into tertiles. After fully adjusted, multivariate logistic regression analysis and subgroup analysis were performed to investigate the association between DII and albuminuria.ResultsA total of 22,607 participants including 2,803 (12.40%) with and 19,804 (87.60%) without albuminuria were enrolled in our study. The albuminuria increased with the increasing DII tertiles (Tertile 1: 10.81%; Tertile 2: 12.41%; Tertile 3:13.97%, P < 0.001). After fully adjusting for covariates, multivariate logistic regression showed that the higher the DII, the greater the odds of albuminuria (OR = 1.19; 95% CI, 1.00–1.41, P < 0.001). Subgroup analysis and interaction test of participants found that the positive correlation between DII and albuminuria was not significantly related to gender, age, BMI, hypertension, diabetes, and eGFR (P for interaction >0.05).ConclusionElevated DII is associated with high odds of albuminuria. Further large-scale prospective studies are still needed to analyze the role of DII in albuminuria.

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“…This finding aligns with research results from published studies. A cross-sectional study involving Iranian adults showed that individuals with higher DII scores had lower eGFR levels [ 10 ]. Another cross-sectional study focusing on the Iranian CKD population revealed an increased risk of advanced CKD stages in the highest DII quartile group [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, previous research has highlighted the significance of a healthy dietary pattern in the management of CKD [ 9 ]. Consuming an anti-inflammatory diet rich in Ω-3 Polyunsaturated Fatty Acid (PUFA), vitamins and fiber has been associated with a reduced risk of proteinuria and an improvement in kidney function [ 10 ]. Conversely, the intake of nutrients generally considered pro-inflammatory, such as saturated fatty acids and sugars, is associated with an increased risk of worsening kidney function [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Association of Dietary Inflammatory Index with CKD progression and estimated glomerular filtration rate in the American CKD population: A cross-sectional study

Xu,

Li,

Jiang

et al. 2024

PLoS ONE

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Purpose The number of CKD patients is on the rise worldwide, and diet has become an essential aspect influencing the treatment and prognosis of CKD. However, limited research has explored the association of the Dietary Inflammatory Index (DII) with CKD progression and the essential kidney function indicator, eGFR, in CKD patients. This study aimed to analyze the association between DII and CKD progression and eGFR in the US CKD population using data from the National Health and Nutrition Examination Survey (NHANES). Methods This study utilized data obtained from the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2018, with a total sample size of 2,488 individuals. Study used multiple imputation, based on 5 replications and a chained equation approach method in the R MI procedure, to account for missing data. Weighted multiple logistic regression was used to analyze the relationship between DII and the risk of higher CKD stage and a weighted multiple regression analysis was used to assess the relationship between DII and eGFR. Weighted Generalized Additive Models and smoothed curve fitting were applied to detect potential non-linear relationships in this association. Results In all three models, it was found that DII was positively associated with the risk of higher CKD stage (P < 0.0001), and an increase in DII was associated with a decrease in eGFR (P < 0.0001). The trend across quartiles of DII remained statistically significant, revealing a gradual elevation in higher CKD stage risk and reduction in eGFR levels for the second, third, and fourth quartiles compared to the lowest quartile (P for trend < 0.0001). Upon adjusting for age, gender, race, education level, poverty income ratio (PIR), marital status, body mass index (BMI), metabolic equivalent (MET) score, drinking, smoking, history of hypertension, history of diabetes, cotinine, systolic blood pressure, diastolic blood pressure, total triglycerides, and total cholesterol, we found a positive correlation between DII and the risk of higher CKD stage (OR = 1.26, 95% CI: 1.14–1.40). Further investigation revealed that an increase in DII was associated with a decrease in eGFR (β = -1.29, 95% CI: -1.75, -0.83). Smooth curves illustrated a non-linear positive correlation between DII and CKD risk, while a non-linear negative correlation was observed between DII and eGFR. Conclusions Our study results indicate that an increase in DII is associated with an increased risk of higher CKD stage and a decrease in eGFR in all three models. In the fully adjusted model, the risk of higher CKD stage increased by 26% and the eGFR decreased by 1.29 ml/min/1.73 m2 for each unit increase in DII. This finding suggests that in patients with CKD in the US, improved diet and lower DII values may help slow the decline in eGFR and delay the progression of CKD.

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Association of dietary inflammatory index with chronic kidney disease and kidney stones in Iranian adults: A cross-sectional study within the Ravansar non-communicable diseases cohort

Cited by 16 publications

References 42 publications

The dietary inflammatory index and its association with the prevalence of hypertension: A cross-sectional study

The dietary inflammatory index and its association with the prevalence of hypertension: A cross-sectional study

Association between dietary inflammation index and albuminuria: results from the National Health and Nutrition Examination Survey

Association of Dietary Inflammatory Index with CKD progression and estimated glomerular filtration rate in the American CKD population: A cross-sectional study

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