Association of Dietary Inflammatory Index With Depression and Suicidal Ideation in Older Adult: Results From the National Health and Nutrition Examination Surveys 2005–2018

Xiao, Yingqi; Huang, Wei

doi:10.3389/fpsyt.2022.944154

Cited by 4 publications

(1 citation statement)

References 27 publications

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“…Meanwhile, it was reported that dietary pattern, evaluated by the dietary inflammatory index (DII), was associated with various inflammatory markers, including CRP, IL-6, and homocysteine [12,13]. In addition, higher DII scores have been shown to be associated with poor health and higher risk of diseases, such as obesity [14], various cancer [15,16], cardiovascular disease (CVD) [14,17], chronic obstructive pulmonary disease [18], depression [19,20], metabolic syndrome [21], type 2 diabetes [14,22], and kidney stones [23].…”

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confidence: 99%

A Proinflammatory Diet Is Associated with Higher Risk of Peripheral Artery Disease

et al. 2022

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Peripheral arterial disease (PAD) has a strong relationship with inflammation. However, it is unclear whether the dietary inflammatory potential is associated with PAD. We aimed to address this knowledge gap. The dietary inflammatory index (DII) was obtained using a 24-h dietary recall interview for each individual. Logistic regression models and restricted cubic spline were performed to assess the relationship of DII with the prevalence of PAD. In addition, Spearman correlation analysis and subgroup analysis were also undertaken. In total, 5840 individuals from the 1999–2004 National Health and Nutrition Examination Survey (NHANES) were enrolled in our study. Participants in higher DII quartile tended to have higher rates of PAD. The increase in DII scores showed a positive association with PAD after fully multivariate adjustment (OR (odds ratios) = 1.094, 95% confidence interval (CI): 1.022–1.171). The multivariable-adjusted OR and 95% CI of the highest DII index quartile compared with the lowest quartile was 1.543 (95% CI: 1.116–2.133). Subgroup analysis demonstrated that the positive association between DII and PAD was persistent across population subgroups. In conclusion, we report that a proinflammatory dietary pattern is related to a higher risk of developing PAD among US adults.

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Section: Introductionmentioning

confidence: 99%

A Proinflammatory Diet Is Associated with Higher Risk of Peripheral Artery Disease

et al. 2022

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Association between uric acid and the risk of depressive symptoms in US adults: results from NHANES 2005–2018

Wang,

Yang,

Lin

et al. 2024

Sci Rep

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Background This study explores the relationship between serum uric acid(UA) levels and depression. UA is the final product of purine metabolism in the human body, possessing certain physiological functions such as blood pressure regulation, antioxidation, DNA protection, and anti-aging, thereby drawing attention for its potential role in preventing and treating depression. Methods This cross-sectional study includes 32,424 participants aged ≥ 20 years from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2018, generating a nationally representative database. Depressive symptoms were assessed using the Patient Health Questionnaire-9. Serum uric acid concentration was measured using the uricase-peroxidase coupled method, and participants were divided into quartiles of serum uric acid concentration. Weighted data were calculated according to analysis guidelines. The association between serum uric acid and depressive symptoms was analyzed using weighted multivariable logistic regression models and restricted cubic spline regression analyses. Subgroup analyses were also performed. Results Among 32,424 participants, 3,421 were defined as having depressive symptoms. The crude prevalence of depressive symptoms was 10.5% (weighted prevalence: 9.086% [95% confidence interval: 9.032–9.139%]). Compared with the first quartile, individuals with higher UA levels had a decreased risk of depressive symptoms by 9% (OR: 0.910, 95% CI: 0.797–10.40), 14.6% (OR: 0.854, 95% CI: 0.741–0.983), and 20.5% (OR: 7795, 95% CI: 0.680–0.930), respectively. Further restricted cubic spline regression analysis revealed a nonlinear association between UA and depressive symptoms, with an inflection point of 319.72 µmol/L. Subgroup multivariable weighted logistic regression analysis found that the association between UA and the risk of depressive symptoms remained consistent across all subgroups, demonstrating high stability and reliability. Conclusion This study emphasizes a significant nonlinear negative correlation between serum uric acid and depressive symptoms. This suggests that proper control of serum uric acid levels may play a role in preventing and treating depression.

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The association between triglyceride glucose index and suicidal ideation in American adults: Results from NHANES 2005 to 2018

Lu,

Zhou,

Shen

et al. 2024

Medicine

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Previous studies have shown a significant association between the triglyceride glucose index (TyG) and suicidal ideation in Korean women. However, this association has not yet been examined among American adults. This study aims to investigate the association between TyG and suicidal ideation using data from the National Health and Nutrition Examination Survey. The National Health and Nutrition Examination Survey database from 2005 to 2018 was used, including samples ≥20 years old. Suicidal ideation was assessed through questionnaires, and the TyG was derived from fasting triglyceride and glucose measurements. Weighted logistic regression models were used to analyze the relationship between the TyG and suicidal ideation. Generalized additive model curves explored the nonlinear relationship, while stratified and sensitivity analyses assessed potential interactions and the robustness of the findings. A significance level of P < .05 was considered statistically significant. A total of 15,694 participants were enrolled, of whom 3.67% participants showed suicidal ideation. The mean TyG index for participants with or without suicidal ideation was 8.82 ± 0.76, 8.65 ± 0.68, respectively (P < .001). Multivariable logistic regression showed that a higher level of TyG were associated with a higher likelihood of suicidal ideation (OR = 1.20; 95% CI, 1.05–1.38) after full adjustment. Subgroup analysis and interaction tests showed no significant correlation between gender, age, race, marital status, education, body mass index, poverty income ratio, smoking status, drinking status, diabetes, hypertension, stroke, and cancer (P > .05 for all interactions). Our findings confirm a significant and positive association between the TyG and suicidal ideation among American adults. Further large-scale prospective studies are needed to analyze the role of TyG in suicidal ideation.

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Association of Dietary Inflammatory Index With Depression and Suicidal Ideation in Older Adult: Results From the National Health and Nutrition Examination Surveys 2005–2018

Cited by 4 publications

References 27 publications

A Proinflammatory Diet Is Associated with Higher Risk of Peripheral Artery Disease

A Proinflammatory Diet Is Associated with Higher Risk of Peripheral Artery Disease

Association between uric acid and the risk of depressive symptoms in US adults: results from NHANES 2005–2018

The association between triglyceride glucose index and suicidal ideation in American adults: Results from NHANES 2005 to 2018

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