Association of Dietary Niacin Intake with Diabetes in Adults in the
                    United States

Liu, Chan; Duan, Wenjuan; Xu, Wenming

doi:10.1055/a-2038-0476

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…Niacin might influence DNA repair, genomic stability, and the immune system, eventually impacting cancer risk, but its metabolism requires complex interactions [ 52 ]. Moreover, it can be influenced by numerous factors such as income, education level, race, and comorbidity [ 66 ]. To date, identifying the correct dose for cancer prevention is challenging since niacin intake is highly variable across the population, exceeding the tolerable upper intake level [ 66 ], and some uncertainty exists about the potential benefit, even in other conditions (diabetes, cardiovascular disease, and neurological disorders) [ 52 , 66 , 67 , 68 ].…”

Section: Discussionmentioning

confidence: 99%

The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis

Tosti,

Pepe,

Gnagnarella

et al. 2023

Nutrients

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Background: Nicotinamide is the active form of vitamin B3 (niacin) obtained through endogenous synthesis, mainly through tryptophan metabolism and dietary supplements, fish, meats, grains, and dairy products. It participates in cellular energy metabolism and modulates multiple cellular survival and death pathways. Nicotinamide has been widely studied as a safe chemopreventive agent that reduces actinic keratosis (AKs) and non-melanoma skin cancers (NMSC). Methods: We used the Medline, EMBASE, PubMed, and Cochrane databases to search the concepts “nicotinamide”, “chemoprevention”, and “skin cancer” up to August 2023. Three independent authors screened titles and abstracts for intervention and study design before searching full texts for eligibility criteria. The primary outcome was the impact of oral nicotinamide on the incidence of NMSC in high-risk patients. We also conducted a systematic search to identify relevant epidemiological studies published evaluating dietary niacin intake and the risk of NMSC. Results: Two hundred and twenty-five studies were reviewed, and four met the inclusion criteria. There was no association between NAM consumption and risk for squamous cell carcinoma (SCC) (rate ratio (RR) 0.81, 95% CI 0.48–1.37; I2 = 0%), basal cell carcinoma (BCC) (RR 0.88, 95% CI 0.50–1.55; I2 = 63%), and NMSC (RR 0.82, 95% CI 0.61–1.12; I2 = 63%). Adverse events were rare and acceptable, allowing optimal compliance of patients to the treatment. We found only one article evaluating the association between niacin dietary intake and NMSC risk, supporting a potential beneficial role of niacin intake concerning SCC but not BCC or melanoma. Conclusions: The present meta-analysis shows, by pooling immunocompetent and immunosuppressed patients, that there is insufficient evidence that oral nicotinamide therapy significantly reduces the number of keratinocyte cancers.

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Section: Discussionmentioning

confidence: 99%

The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis

Tosti,

Pepe,

Gnagnarella

et al. 2023

Nutrients

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“…However, the studies regarding vitamin B3 demonstrate a more contradictory picture. While cross-sectional studies have indicated an inverse correlation [ 20 , 21 , 22 ], Pan et al have reported a positive correlation, underscoring the complexity of this relationship [ 23 ]. Folic acid (vitamin B9) presents another intriguing case.…”

Section: Introductionmentioning

confidence: 99%

Joint B Vitamin Intake and Type 2 Diabetes Risk: The Mediating Role of Inflammation in a Prospective Shanghai Cohort

Zhu,

Ying,

et al. 2024

Nutrients

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Background and Aims: Type 2 diabetes (T2D) is a global and complex public health challenge, and dietary management is acknowledged as critical in its prevention. Recent studies have highlighted the involvement of micronutrients in T2D pathophysiology; our study aims to assess the association between B vitamin intake and T2D risks and the mediating role of inflammation. Methods: In a prospective cohort design, data on B vitamins intake, including thiamine (B1), riboflavin (B2), niacin (B3), pyridoxine (B6), folate (B9), and cobalamin (B12), was obtained using a validated food frequency questionnaire (FFQ), and blood inflammatory biomarkers were analyzed according to standard protocol in the local hospitals at baseline from 44,960 adults in the Shanghai Suburban Adult Cohort and Biobank (SSACB). Incident T2D cases were identified according to a physician’s diagnosis or medication records from the electronic medical information system. We employed logistic and weighted quantile sum regression models to explore the associations of single and combined levels of B vitamins with T2D and mediation analyses to investigate the effects of inflammation. Results: Negative correlations between B vitamins and T2D were observed in the single-exposure models, except for B3. The analyses of joint exposure (B1, B2, B6, B9, and B12) also showed an inverse association (OR 0.80, 95% CI 0.71 to 0.88), with vitamin B6 accounting for 45.58% of the effects. Further mediation analysis indicated a mediating inflammatory impact, accounting for 6.72% of the relationship. Conclusions: Dietary intake of B vitamins (B1, B2, B6, B9, B12) was associated with a reduced T2D risk partially mediated by inflammation in Shanghai residents.

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Impaired sensitivity to thyroid hormones is associated with all-cause and cause-specific mortality among chronic kidney disease patients: results from National Health and Nutrition Examination Survey (NHANES) 2007–2012

Liu,

Zhu,

Wang

et al. 2024

Renal Failure

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Background Resistance to thyroid hormone shows underlying mechanical link with chronic kidney disease (CKD) and is prevalent in CKD population. However, whether it attributes to mortality risk among CKD population is unknown. This study aimed to examine the association of thyroid hormone resistance (THR) with all-cause and cause-specific mortality among CKD individuals. Methods This study extracted CKD population from the National Health and Nutrition Examination Survey (NHANES) 2007–2012. Death outcomes were ascertained by linkage to National Death Index records through 31 December 2019. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence interval (CI) for mortality from all causes, cardiovascular disease (CVD). Results A total of 1,634 adults with CKD were included in the cohort, in which 663 deaths were recorded during an average follow-up of 8.72 years. After multivariate adjustment, resistance to thyroid hormone was significantly associated with higher all-cause and CVD mortality. There was an 18% and 31% increase in risks of all-cause and CVD mortality per-standard deviation (SD) increment in Parametric Thyroid Feedback Quantile-based Index (PTFQI) respectively. When PTFQI was analyzed as categorical variable (classified according to PTFQI percentiles), after adjusted for potential confounders and taking PTFQI ≤ P 5 as reference, the HRs and 95% CIs in category with PTFQI > P 95 for all-cause mortality and CVD mortality were 2.12 [1.10, 4.09] ( p for trend 0.026) and 5.14 [1.81, 14.60] for ( p for trend 0.018), respectively. Conclusions Resistance to thyroid hormone, centered on variations in the typical pituitary response to thyroid hormones, may independently correlate with all-cause and CVD mortality in CKD patients.

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Association of Dietary Niacin Intake with Diabetes in Adults in the United States

Cited by 4 publications

References 37 publications

The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis

The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis

Joint B Vitamin Intake and Type 2 Diabetes Risk: The Mediating Role of Inflammation in a Prospective Shanghai Cohort

Impaired sensitivity to thyroid hormones is associated with all-cause and cause-specific mortality among chronic kidney disease patients: results from National Health and Nutrition Examination Survey (NHANES) 2007–2012

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