Association of Dietary Patterns With Testicular Function in Young Danish Men

Nassan, Feiby L.; Jensen, Tina Kold; Priskorn, Lærke; Halldórsson, Thorhallur I.; Chavarro, Jorge E.; Jørgensen, Niels O. G.

doi:10.1001/jamanetworkopen.2019.21610

Cited by 36 publications

(29 citation statements)

References 47 publications

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“…Fifteen peer-reviewed research studies comprised the primary citations used by 34 of the 52 total articles links (Table 4) [9][10][11][12][13][14][15][16][17][18][19][20][21][22]. The remaining 18 links did not cite original peer-reviewed scientific studies, or purported study data were not accessible.…”

Section: Resultsmentioning

confidence: 99%

Social Media Sensationalism in the Male Infertility Space: A Mixed Methodology Analysis

Zaila

Osadchiy

Shahinyan

et al. 2020

World J Mens Health

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Section: Resultsmentioning

confidence: 99%

Social Media Sensationalism in the Male Infertility Space: A Mixed Methodology Analysis

Zaila

Osadchiy

Shahinyan

et al. 2020

World J Mens Health

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“…In accordance with the role of testosterone in affecting sperm maturation and development, our study also found that testosterone-related dietary pattern decreased the SC and percentage of NSM, suggesting a reduction in spermatogenesis. However, a recent study conducted among 2935 Danish men showed reversed results [ 11 ]. The authors reported that men with the highest adherence to the Western pattern had higher testosterone levels compared to men with less adherence.…”

Section: Discussionmentioning

confidence: 99%

“…The authors reported that men with the highest adherence to the Western pattern had higher testosterone levels compared to men with less adherence. Nevertheless, the FSH and LH levels have remained unchanged regardless of the adherence to the dietary patterns [ 11 ]. In our study, it appears that higher quartiles of the testosterone-related dietary pattern may lead to increased aromatization of testosterone to estradiol ( Table S1 ).…”

Section: Discussionmentioning

confidence: 99%

“…According to the current meta-regression study reported that sperm concentration (SC) and total sperm count (TSC) declined by 50–60% in total between 1973 and 2011 particularly among Western countries [ 5 ]. In spite of socio- and lifestyle factors such as age, obesity, smoking, alcohol consumption, and physical activity that can affect the testosterone levels and sperm quality, [ 6 , 7 , 8 , 9 , 10 ] accumulating evidence indicates that diet could play a crucial role in influencing male sex hormone and sperm quality [ 11 , 12 ]. Recent studies conducted in Western countries similarly reported that adherence to a healthy prudent diet has a better testicular function (higher total sperm count or concentration and testosterone levels) [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Association of Testosterone-Related Dietary Pattern with Testicular Function among Adult Men: A Cross-Sectional Health Screening Study in Taiwan

et al. 2021

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Diets could play an important role in testicular function, but studies on how adherence to the dietary patterns influences human testicular function in Asian countries are scarce. Herein, we examined the association between testosterone-related dietary patterns and testicular function among adult men in Taiwan. This cross-sectional study recruited 3283 men who attended a private medical screening program from 2009 to 2015. Testosterone-related dietary pattern was generated by the reduced rank regression (RRR) method. The association between adherence to quartile of dietary pattern scores with sex hormones (testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2)) and sperm quality (sperm concentration (SC), total sperm motility (TSM), progressive motility (PRM), and normal sperm morphology (NSM)) were examined by multivariable linear regression. Hemoglobin (β = 0.57, p < 0.001), hematocrit (β = 0.17, p = 0.002), triglyceride (β = −0.84, p < 0.001), HDL-cholesterol (β = 3.58, p < 0.001), total cholesterol to HDL-cholesterol ratio (β = −0.78, p < 0.001), and uric acid (β = −10.77, p < 0.001) were highly correlated with testosterone levels. Therefore, these biomarkers were used to construct a testosterone-related dietary pattern. Highest adherence (Q4) to dietary pattern scores were negatively associated with lower testosterone in the pooled analysis (β = −0.89, p = 0.037) and normal-weight men (β = −1.48, p = 0.019). Likewise, men in the Q4 of the dietary pattern had lower SC (β = −5.55, p = 0.001) and NSM (β = −2.22, p = 0.007) regardless of their nutritional status. Our study suggesting that testosterone-related dietary pattern (rich in preserved vegetables or processed meat or fish, deep-fried foods, innards organs, rice or flour products cooked in oil, and dipping sauce, but low in milk, dairy products, legumes, or beans, and dark or leafy vegetables) was associated with a poor testicular function.

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“…In the face of emerging pandemics causing city lockdown and health care need for remote regions, tele-medicine will prevail and requires on-line processes of data and analysis connected with off-line point-of-care tests for end users. The Bemaner system is a prime example of this type of implementation, especially for infertility, which is always related to the following aspects: environmental pollution, life style, and diet [ 15 - 17 ], the analysis of big data could contribute much more than traditional case reports in research [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Web- and Artificial Intelligence–Based Image Recognition For Sperm Motility Analysis: Verification Study

Tsai¹,

Zhuang²,

Pong³

et al. 2020

JMIR Med Inform

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Background Human sperm quality fluctuates over time. Therefore, it is crucial for couples preparing for natural pregnancy to monitor sperm motility. Objective This study verified the performance of an artificial intelligence–based image recognition and cloud computing sperm motility testing system (Bemaner, Createcare) composed of microscope and microfluidic modules and designed to adapt to different types of smartphones. Methods Sperm videos were captured and uploaded to the cloud with an app. Analysis of sperm motility was performed by an artificial intelligence–based image recognition algorithm then results were displayed. According to the number of motile sperm in the vision field, 47 (deidentified) videos of sperm were scored using 6 grades (0-5) by a male-fertility expert with 10 years of experience. Pearson product-moment correlation was calculated between the grades and the results (concentration of total sperm, concentration of motile sperm, and motility percentage) computed by the system. Results Good correlation was demonstrated between the grades and results computed by the system for concentration of total sperm (r=0.65, P<.001), concentration of motile sperm (r=0.84, P<.001), and motility percentage (r=0.90, P<.001). Conclusions This smartphone-based sperm motility test (Bemaner) accurately measures motility-related parameters and could potentially be applied toward the following fields: male infertility detection, sperm quality test during preparation for pregnancy, and infertility treatment monitoring. With frequent at-home testing, more data can be collected to help make clinical decisions and to conduct epidemiological research.

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Association of Dietary Patterns With Testicular Function in Young Danish Men

Abstract: IMPORTANCE Diet may play a role in testicular function, but data on how adherence to different diet patterns influences human testicular function are scarce. OBJECTIVE To determine whether adherence to specific dietary patterns is associated with testicular function in young men.

Cited by 36 publications

References 47 publications

Social Media Sensationalism in the Male Infertility Space: A Mixed Methodology Analysis

Social Media Sensationalism in the Male Infertility Space: A Mixed Methodology Analysis

Association of Testosterone-Related Dietary Pattern with Testicular Function among Adult Men: A Cross-Sectional Health Screening Study in Taiwan

Web- and Artificial Intelligence–Based Image Recognition For Sperm Motility Analysis: Verification Study

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