Association of dietary selenium intake with telomere length in middle-aged and older adults

Shu, Yan-Wen; Wu, Mingyang; Yang, Senbei; Wang, Youjie; Li, Huawen

doi:10.1016/j.clnu.2020.01.014

Cited by 42 publications

(36 citation statements)

References 43 publications

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“…Recent NHANES data showed a positive association between dietary selenium intake and TL in adults, suggesting a potential role of selenium in the maintenance of the TL ( 54 ). In the present study, we found no difference in placenta or cord blood rTL in relation to the serum selenium concentrations.…”

Section: Discussionmentioning

confidence: 99%

Placental and Cord Blood Telomere Length in Relation to Maternal Nutritional Status

Vahter

Broberg

Harari

2020

The Journal of Nutrition

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Background The uterine environment may be important for the chromosomal telomere length (TL) at birth, which, in turn, influences disease susceptibility throughout life. However, little is known about the importance of specific nutritional factors. Objectives We assessed the impact of multiple maternal nutritional factors on TL in placenta and cord blood. Methods In a population-based mother–child cohort in northwestern Argentina, we measured maternal weight, BMI, body fat percentage (BFP), and several nutrients [selenium, magnesium, calcium, zinc, manganese, iodine, vitamin B-12, folate, 25-hydroxycholecalciferol (25(OH)D3)], hemoglobin, and homocysteine in maternal whole blood, serum, plasma, or urine during pregnancy (mean gestational week 27). We measured the relative TL (rTL) in placenta (n = 99) and cord blood (n = 98) at delivery by real-time PCR. Associations were evaluated by multivariable-adjusted linear regression. Results The women's prepregnancy BMI (kg/m2; mean ± SD: 23.7 ± 4.1), body weight (55.4 ± 9.9 kg), and BFP (29.9 ± 5.5%), but not height (153 ± 5.3 cm), were inversely associated with placental rTL (P < 0.01 for all), with ∼0.5 SD shorter rTL for an IQR increase in prepregnancy body weight, BMI, or BFP. Also, impedance-based BFP, but not lean body mass, in the third trimester was associated with shorter placental rTL. In addition, serum vitamin B-12 (232 ± 96 pmol/L) in pregnancy (P = 0.038), but not folate or homocysteine, was associated with shorter placental rTL (0.2 SD for an IQR increase). In contrast, plasma 25(OH)D3 (46 ± 15 nmol/L) was positively associated with placental rTL (P < 0.01), which increased by 0.4 SD for an IQR increase in 25(OH)D3. No clear associations of the studied maternal nutritional factors were found with cord blood rTL. Conclusions Maternal BMI, BFP, and vitamin B-12 were positively associated, whereas 25(OH)D3 was inversely associated, with placental TL. No association was observed with cord blood TL. Future studies should elucidate the role of placental TL for child health.

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Section: Discussionmentioning

confidence: 99%

Placental and Cord Blood Telomere Length in Relation to Maternal Nutritional Status

Vahter

Broberg

Harari

2020

The Journal of Nutrition

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“…A defect in the selenoprotein synthetic machinery causing deficient levels of many selenoproteins has been related to shortened telomeres in peripheral blood monocytes [117]. A recent observational study indicated that dietary Se intake was related to longer telomeres in middle-aged and older adults in America [118]. These results were in accordance with observations by Wu et al, who showed that dietary Se deprivation induced telomere shortening in colonocytes of mice carrying humanized telomeres (G3 It is well known that the inhibitions of other classes of histone deacetylases (HDAC) (i.e., class I, II, and IV) may delay ageing and promote longevity in experimental systems by, i.a., contributing to the maintenance of histone acetylation and genome stability [111].…”

Section: Selenium Genomic Stability and Telomere Lengthmentioning

confidence: 99%

Impact of Selenium on Biomarkers and Clinical Aspects Related to Ageing. A Review

et al. 2021

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Selenium (Se) is an essential dietary trace element that plays an important role in the prevention of inflammation, cardiovascular diseases, infections, and cancer. Selenoproteins contain selenocysteine in the active center and include, i.e., the enzymes thioredoxin reductases (TXNRD1–3), glutathione peroxidases (GPX1–4 and GPX6) and methionine sulfoxide reductase, involved in immune functions, metabolic homeostasis, and antioxidant defense. Ageing is an inevitable process, which, i.e., involves an imbalance between antioxidative defense and reactive oxygen species (ROS), changes in protein and mitochondrial renewal, telomere attrition, cellular senescence, epigenetic alterations, and stem cell exhaustion. These conditions are associated with mild to moderate inflammation, which always accompanies the process of ageing and age-related diseases. In older individuals, Se, by being a component in protective enzymes, operates by decreasing ROS-mediated inflammation, removing misfolded proteins, decreasing DNA damage, and promoting telomere length. Se-dependent GPX1–4 and TXNRD1–3 directly suppress oxidative stress. Selenoprotein H in the cell nucleus protects DNA, and selenoproteins residing in the endoplasmic reticulum (ER) assist in the removal of misfolded proteins and protection against ER stress. In this review, we highlight the role of adequate Se status for human ageing and prevention of age-related diseases, and further its proposed role in preservation of telomere length in middle-aged and elderly individuals.

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“…The types and amounts of all foods and beverages during the 24-h period prior to the interview were collected with the use of a computer-assisted dietary interview system. The dietary magnesium intake was estimated based on the University of Texas Food Intake Analysis System and U.S. Department of Agriculture Survey Nutrients Database [22]. The nutrient estimates did not include nutrients obtained from medications or dietary supplements.…”

Section: Dietary Magnesium Intakementioning

confidence: 99%

“…However, whether LTL plays a role in prolonging lifespan with magnesium intake remains unclear. Although some studies have explored the associations between minerals intake (e.g., copper, zinc and selenium) and LTL [22][23][24], the association of dietary magnesium intake with LTL has rarely been examined. Of note, the possible effect modi ers for the dietary magnesium intake-LTL association have not been fully investigated in previous studies.Therefore, the present study aimed to address the knowledge gap by examining the association of dietary magnesium intake with LTL and explore any possible effect modi ers in US middle-aged and elderly adults using a large population based survey data, the National Health and Nutrition Examination Survey (NHANES).…”

Section: Introductionmentioning

confidence: 99%

Dietary Magnesium Intake and its Association with Leukocyte Telomere Length in US Middle-aged and Elderly Adults

Bai

et al. 2021

Preprint

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Background: Magnesium supplementation may extend the life span; however, the biological mechanism is still unknown. Leukocyte telomere length (LTL) is a marker of cell aging and biological health in humans. Data concerning whether magnesium supplementation can maintain telomere length, thus prolonging life are limited.Purpose: To investigate the association between dietary magnesium intake and LTL in US middle-aged and elderly adults. Methods: A total of 4039 US adults aged ≥45 years from National Health and Nutrition Examination Survey (NHANES, 1999-2002). Dietary magnesium intake was collected by a trained interviewer using 24-hour dietary recall method and LTL was obtained using the quantitative polymerase chain reaction (PCR) method. Multivariate linear regression analysis was performed to evaluate the the crude and adjusted association of dietary magnesium intake with LTL. Results: The overall mean (SD) of LTL was 5.6 (0.6) kp. After adjusting potential confounders, every 1 mg increase in log-transformed dietary magnesium intake was associated with 0.20 kp [95% confidence intervals (CI): 0.05-0.34] longer LTL. Participants with the highest tertile (≥ 299 mg) of dietary magnesium intake had statistically significant longer LTL (β = 0.07, P=0.038) compared with the lowest tertile (< 198 mg), with significant linear trends across tertiles. Moreover, the association between dietary magnesium intake and LTL was significantly stronger in participants with higher levels of education (≥ high school compared with < high school, P for interaction = 0.002). E-value analysis suggested robustness to unmeasured confounding.Conclusions: Our findings suggested that increased dietary magnesium intake was associated with longer LTL. Theses warrant additional investigation.

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Association of dietary selenium intake with telomere length in middle-aged and older adults

Cited by 42 publications

References 43 publications

Placental and Cord Blood Telomere Length in Relation to Maternal Nutritional Status

Placental and Cord Blood Telomere Length in Relation to Maternal Nutritional Status

Impact of Selenium on Biomarkers and Clinical Aspects Related to Ageing. A Review

Dietary Magnesium Intake and its Association with Leukocyte Telomere Length in US Middle-aged and Elderly Adults

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