Association of Dietary Total Antioxidant Capacity with Bone Mass and Osteoporosis Risk in Korean Women: Analysis of the Korea National Health and Nutrition Examination Survey 2008–2011

Kim, Donghyun; Han, Anna; Park, Yongsoon

doi:10.3390/nu13041149

Cited by 21 publications

(16 citation statements)

References 42 publications

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“…DTAC was calculated according to the total antioxidant capacity (mg VCE) multiplied by the intake of each food (g) estimated from 24 h recall [28]. DTAC was categorized into the 17 food groups suggested by the Korea National Health and Nutrition Examination Survey: grains, potatoes, sugars and sweets, legumes, nuts and seeds, vegetables, mushrooms, fruits, meats, poultry, eggs, fish and shellfish, seaweeds, milk and dairy products, oils and fats, beverages and alcohols, seasonings, and others [29].…”

Section: Estimation Of Dtacmentioning

confidence: 99%

Relationship between Dietary Total Antioxidant Capacity and the Prognosis of Amyotrophic Lateral Sclerosis

et al. 2022

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Antioxidant intake has been suggested to be associated with the prognosis of amyotrophic lateral sclerosis (ALS). This study aimed to investigate whether dietary total antioxidant capacity (DTAC) and that of major food groups are related to disease progression rate (ΔFS) and survival time in ALS patients. A total of 301 participants diagnosed with sporadic ALS according to the revised El Escorial criteria were recruited from March 2011 and followed up to the event occurrence, or the end of October 2021. Events included percutaneous endoscopic gastrostomy, tracheostomy, and death. DTAC was estimated using task automation and an algorithm based on 24 h dietary recall. ΔFS was negatively correlated with the vegetable and legume DTAC, and event-free survival was different among the tertiles of vegetables and legumes DTAC. Consistently, the risk of events was negatively associated with DTAC from vegetables and legumes. These results suggest that the intake of antioxidants, especially those derived from vegetables and legumes, has a beneficial effect on delaying disease progression and prolonging survival in patients with ALS. Further studies with large prospective cohorts and clinical trials are needed to determine whether the consumption of foods with high DTAC improves the prognosis of ALS.

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Section: Estimation Of Dtacmentioning

confidence: 99%

Relationship between Dietary Total Antioxidant Capacity and the Prognosis of Amyotrophic Lateral Sclerosis

et al. 2022

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“…Malabsorption of vitamin C has been linked to the development of low BMD and osteoporosis in inflammatory bowel disease patients [ 9 ]. Scholarly reviews conclude that consumption of a vitamin-C-rich diet was negatively associated with decreased risk of hip fracture, osteoporosis, and loss of BMD [ 10 , 11 , 12 , 13 , 14 ]. Rondanelli et al [ 14 ] elegantly summarized various studies providing evidence for a positive association between vitamin C supplementation and BMD improvement.…”

Section: Introductionmentioning

confidence: 99%

The Positive Association of Plasma Levels of Vitamin C and Inverse Association of VCAM-1 and Total Adiponectin with Bone Mineral Density in Subjects with Diabetes

et al. 2022

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Context. Population studies have shown a trend in decreasing vitamin C status and increasing prevalence of osteoporosis in patients with diabetes and non-diabetic people. Dietary vitamin C consumption is linked to improvement in bone mineral density (BMD) in epidemiological studies. VCAM-1 and adiponectin are known to activate osteoclasts, which increase bone loss. Aim: This study examined whether there is any association between the circulating level of vitamin C and BMD and whether the beneficial effect of vitamin C on BMD was linked to a simultaneous decrease in circulating levels of adiponectin and VCAM-1 in subjects with diabetes. Methods: Patients with diabetes (T2D, n = 74) and age-matched non-diabetic controls (n = 26) were enrolled in this study. Fasting blood levels of glycemia, adiponectin, VCAM-1, inflammation biomarkers, and vitamin C were determined in both groups. The BMD of the lumbar spine (L1–L4), left femur, and right femur was determined using a DXA scan in subjects with diabetes. Results: Patients with diabetes had lower levels of vitamin C and higher levels of VCAM-1 and inflammatory cytokines. There was a significant positive association between vitamin C blood levels and lumbar spine BMD as well as a significant negative association between total adiponectin and VCAM-1 levels with that of vitamin C and lumbar BMD in patients with diabetes. Total adiponectin and VCAM-1 also showed a negative association with BMD of both the right and left femurs. The inter-relationship among the circulating levels of vitamin C and VCAM-1 and BMD was strong and is a novel finding. Conclusions: This study reports a positive association of circulating vitamin C levels and the BMD and that the beneficial effects of vitamin C on BMD could be linked to a simultaneous lowering in circulating VCAM-1 and total adiponectin levels. Thus, dietary vitamin C consumption has potential to lower inflammation and the risk of osteoporosis in subjects with diabetes.

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“…A few researchers have clarified that antioxidant intake plays a crucial role in protecting against oxidative damage and relevant inflammatory complications in people with NAFLD ( 12 ). Currently, dietary total antioxidant capacity (DTAC) is regarded as a useful index to investigate the whole antioxidant capacity of foods ( 13 ). In comparison to a simple sum of certain dietary antioxidants, DTAC provides the cumulative capability of the total dietary antioxidants ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

“…Currently, dietary total antioxidant capacity (DTAC) is regarded as a useful index to investigate the whole antioxidant capacity of foods ( 13 ). In comparison to a simple sum of certain dietary antioxidants, DTAC provides the cumulative capability of the total dietary antioxidants ( 13 ). Accumulating evidence suggests that DTAC is inversely associated with adverse health consequences such as cardiovascular diseases, T2DM, cancer deaths, and obesity ( 14 – 17 ).…”

Section: Introductionmentioning

confidence: 99%

Dietary total antioxidant capacity is inversely associated with the odds of non-alcoholic fatty liver disease in people with type-2 diabetes

et al. 2022

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BackgroundThis study was conducted to evaluate possible associations between Dietary Total Antioxidant Capacity (DTAC) and odds of non-alcoholic fatty liver disease (NAFLD) in people with type-2 diabetes mellitus (T2DM).Materials and methodsWe recruited two hundred people with T2DM, and evaluated their liver steatosis using Fibroscan. Dietary intakes of participants were assessed using a validated food frequency questionnaire. DTAC was computed via ferric reducing antioxidant power (FRAP).ResultsIn the crude model, no statistically significant association was found between DTAC and the odds of NAFLD in people with diabetes. However, after adjustment for potential confounders including age, gender, diabetes duration, smoking status, physical activity, BMI, waist circumference, and energy, the most reduced adjusted OR was indicated for the third tertile vs. the first one (OR: 0.28, 95% CI: 0.09–0.81, P = 0.02), meaning that diabetic patients in the third tertile of DTAC had 72% decreased risk of NAFLD in comparison to those in the first one. The relationship was remained significant after additional adjustment for HOMA-IR, HbA1c, serum Triglyceride (TG), and low-density lipoprotein-cholesterol (LDL) levels (OR: 0.29, 95% CI: 0.09–0.93, P = 0.03). Importantly, a dose-response pattern was demonstrated for DTAC and risk of NAFLD (P = 0.04).ConclusionHigher DTAC was related with a decreased risk of NAFLD in individuals with diabetes.

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Association of Dietary Total Antioxidant Capacity with Bone Mass and Osteoporosis Risk in Korean Women: Analysis of the Korea National Health and Nutrition Examination Survey 2008–2011

Cited by 21 publications

References 42 publications

Relationship between Dietary Total Antioxidant Capacity and the Prognosis of Amyotrophic Lateral Sclerosis

Relationship between Dietary Total Antioxidant Capacity and the Prognosis of Amyotrophic Lateral Sclerosis

The Positive Association of Plasma Levels of Vitamin C and Inverse Association of VCAM-1 and Total Adiponectin with Bone Mineral Density in Subjects with Diabetes

Dietary total antioxidant capacity is inversely associated with the odds of non-alcoholic fatty liver disease in people with type-2 diabetes

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