Association of Dietary Vitamin A and β-Carotene Intake with the Risk of Lung Cancer: A Meta-Analysis of 19 Publications

Yu, Na; Su, Xinming; Wang, Zanfeng; Dai, Bing; Kang, Jian

doi:10.3390/nu7115463

Cited by 69 publications

(49 citation statements)

References 38 publications

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“…Recent meta-analysis confirmed that antioxidant activity of β-carotene and vitamin A delivered from diet may have a protective effect for risk of lung cancer. This is consistent with previous findings on vitamins C and E [58]. It can be assumed that a similar protective effect may be present in the case of many other cancers.…”

Section: Introductionsupporting

confidence: 93%

“…It has been suggested that β-carotene supplementation in high doses among smokers and workers exposed to asbestos could increase the risk of lung cancer [55,56]. Despite unclear data whether or not high levels of β-carotenids contribute to the development of lung cancer, it is now suggested that a higher intake of dietary β-carotene rather reduces lung cancer risk [57]. This indicates that β-carotene from natural sources and synthesized, has a different effect on that risk.…”

Section: Introductionmentioning

confidence: 99%

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Role of vitamin A in health and illness

Marzęda¹,

Łuszczki²

2019

J Pre Clin Clin Res.

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Introduction. Vitamin A is an essential substance for human well-being and survival. It plays a crucial role in many physiological processes, including growth and differentiation of target tissues, reproduction, proper functioning of the retina and modulation of the immune system. Vitamin A deficiency leads to increased risk of severe infections, numerous diseases and pathological conditions, including disorders of vision, bones, epithelial tissue and immunity. It remains one of the main causes of preventable blindness in children. Nonetheless, excessive intake of vitamin A can also cause serious health problems. Objective. The aim of this study is to describe and summarize current knowledge about the role of vitamin A in the human organism, as well as to provide general information on its supplementation. State of Knowledge. Vitamin A is a group of similar organic compounds that cannot be synthesized in the human body, and therefore has to be included in the diet. Vitamin A influences the human body since foetal life. Both deficiency and an excess of vitamin A may cause serious complications. The main sources of the vitamin are meat, fish, poultry and dairy products. Its precursors, such as carotenoids, are present in fruit and vegetables. It is stored mainly in the liver and adipose tissue. Vitamin A has antioxidative attributes. Conclusion. An adequate intake of vitamin A is crucial for maintaining health and well-being, and deficiency as well as overdose of this vitamin may cause serious complications and diseases.

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Section: Introductionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Role of vitamin A in health and illness

Marzęda¹,

Łuszczki²

2019

J Pre Clin Clin Res.

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“…Furthermore, orange carrots has in abundance α-carotene as well as β-carotene (39) , and were found to contain the greatest concentration of total carotenoids (40) among carrots with different colours. Previous studies have suggested that higher category of dietary vitamin A and β-carotene intake could reduce lung cancer risk (41) .…”

Section: Discussionmentioning

confidence: 98%

Is carrot consumption associated with a decreased risk of lung cancer? A meta-analysis of observational studies

Jiang

Yang

et al. 2019

Br J Nutr

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Findings of epidemiological studies regarding the association between carrot consumption and lung cancer risk remain inconsistent. The present study aimed to summarise the current epidemiological evidence concerning carrot intake and lung cancer risk with a meta-analysis. We conducted a meta-analysis of case–control and prospective cohort studies, and searched PubMed and Embase databases from their inception to April 2018 without restriction by language. We also reviewed reference lists from included articles. Prospective cohort or case–control studies reporting OR or relative risk with the corresponding 95 % CI of the risk lung cancer for the highest compared with the lowest category of carrot intake. A total of eighteen eligible studies (seventeen case–control studies and one prospective cohort study) were included, involving 202 969 individuals and 5517 patients with lung cancer. The pooled OR of eighteen studies for lung cancer was 0·58 (95 % CI 0·45, 0·74) by comparing the highest category with the lowest category of carrot consumption. Based on subgroup analyses for the types of lung cancer, we pooled that squamous cell carcinoma (OR 0·52, 95 % CI 0·19, 1·45), small-cell carcinoma (OR 0·43, 95 % CI 0·12, 1·59), adenocarcinoma (OR 0·34, 95 % CI 0·15, 0·79), large-cell carcinoma (OR 0·40, 95 % CI 0·10, 1·57), squamous and small-cell carcinoma (OR 0·85, 95 % CI 0·45, 1·62), adenocarcinoma and large-cell carcinoma (OR 0·20, 95 % CI 0·02, 1·70) and mixed types (OR 0·61, 95 % CI 0·46, 0·81). Exclusion of any single study did not materially alter the pooled OR. Integrated epidemiological evidence from observational studies supported the hypothesis that carrot consumption may decrease the risk of lung cancer, especially for adenocarcinoma.

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“…Wu et al found that treatment with astaxanthin inhibited the phosphorylation of JAK1 and STAT3 in NSCLC‐A549 cells, causing cell growth suppression and apoptotic induction (Wu et al, ). Interestingly, a meta‐analysis reported that dietary β‐carotene can lower the risk of lung cancer (Yu, Su, Wang, Dai, & Kang, ). Furthermore, the association between serum carotenoids and lung cancer mortality demonstrated that high serum levels of these compounds can strongly minimize the risk of death associated with smoking‐related lung cancer (Min & Min, ).…”

Section: Natural Product‐derived Compounds As Potent Inducers Of Cellmentioning

confidence: 99%

Molecular mechanisms of natural compounds in cell death induction and sensitization to chemotherapeutic drugs in lung cancer

Wattanathamsan

Hayakawa

Pongrakhananon

2019

Phytotherapy Research

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Cancer remains one of the leading causes of death worldwide, especially lung cancer.Chemotherapeutic drugs are commonly used for lung cancer treatment; nonetheless, undesirable side effects and drug resistance remain major challenges for therapeutic success. Therefore, harmless and effective treatments against lung cancer are urgently required. The use of natural phytochemical products, in single or combinatorial therapy, is an emerging strategy for prevention and cure of cancer because of the various remarkable anticancer properties of these compounds. Cell death, which primarily occurs via apoptosis and nonapoptotic mechanisms (necrosis, autophagy, and cellular senescence), is one of the antineoplastic effects of natural compounds. In this review, we highlight representative plant-derived compounds with cancer chemopreventive and sensitizing effects in combination with chemotherapeutic drugs with various cell death-inducing mechanisms. Relevant molecular mechanisms implicated in the pharmacological effects of these natural compounds are discussed. Overall, this review provides a reference and new perspective for application of phytochemical agents as potential anti-lung cancer drugs for further cancer drug research and development.

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Association of Dietary Vitamin A and β-Carotene Intake with the Risk of Lung Cancer: A Meta-Analysis of 19 Publications

Cited by 69 publications

References 38 publications

Role of vitamin A in health and illness

Role of vitamin A in health and illness

Is carrot consumption associated with a decreased risk of lung cancer? A meta-analysis of observational studies

Molecular mechanisms of natural compounds in cell death induction and sensitization to chemotherapeutic drugs in lung cancer

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