Association of Different Obesity Phenotypes with Sarcopenia in Han Chinese Middle-Aged and Elderly with Type 2 Diabetes Individuals

Lu, Lanyu; Liu, Bowei; Ma, Yongfang

doi:10.2147/dmso.s398475

Cited by 3 publications

References 37 publications

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Association between metabolic phenotypes and incident pre-sarcopenia: 3 years follow-up of Tehran Lipid and Glucose Study

Abiri,

Ahmadi,

Valizadeh

et al. 2024

BMC Public Health

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Objectives In the context of musculoskeletal health, the emergence of pre-sarcopenia as a precursor to sarcopenia has garnered attention for its potential insights into early muscle loss. We explored the association between different metabolic phenotypes of obesity, and the incidence of pre-sarcopenia over a 3-year follow-up in a cohort from the Tehran Lipid and Glucose Study (TLGS). Methods In this 3-year longitudinal study, 2257 participants were categorized into four groups based on their BMI and metabolic status: metabolically healthy normal weight (MHNW), metabolically healthy overweight/obese (MHO), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy overweight/obese (MUO). The participants were assessed for various anthropometric and body composition indices including muscle mass determined by bioelectrical impedance analysis (BIA). Blood samples were collected for metabolic indices, and participants underwent measurements for blood pressure. Pre-sarcopenia was defined based on low muscle mass. Statistical analyses included logistic regression and chi-squared tests. Results The MUNW group exhibited the highest prevalence of pre-sarcopenia (33.5%), while the MHO group had the lowest (2.8%). Adjusted models revealed that the odds ratio for pre-sarcopenia was higher in the MUNW group (OR = 2.23, P < 0.001), whereas the MHO and MUO groups showed lower odds (OR = 0.11 and 0.13, both P < 0.001). Notably, the association was gender-dependent, with MUNW females having a higher risk even after adjustments (OR = 2.37, P = 0.042). Conclusion Our findings suggest that metabolic health may play a pivotal role in pre-sarcopenia, emphasizing the need for targeted interventions based on both metabolic and obesity phenotypes.

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Association between metabolic phenotypes and incident pre-sarcopenia: 3 years follow-up of Tehran Lipid and Glucose Study

Abiri,

Ahmadi,

Valizadeh

et al. 2024

BMC Public Health

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Relationship between abdominal obesity and C-reactive protein in combination with hypertension in middle-aged and older adults: insights from the CHARLS study

Liao,

Huang,

Wang

et al. 2024

Preprint

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Background Hypertension is a global public health problem, and as good prevention and management of hypertension can effectively reduce the risk of myocardial infarction and stroke, thereby significantly reducing the health economic burden, exploring more risk factors used to identify hypertension remains necessary. Aim To investigate whether the combination of elevated hs-CRP levels and abdominal obesity increases the risk of hypertension in middle-aged and older adults. Methods This study used data from 3439 investigators aged 45 years and older who participated in the 2015 China Health and Retirement Longitudinal Study (CHARLS). Hypertension, waist circumference, and hs-CRP were measured. logistic regression adjusted for confounding variables was used to examine the association between abdominal obesity and hs-CRP under the combination with hypertension. Results The risk of hypertension was significantly increased when participants had both abdominal obesity and high hs-CRP levels. Even after adjusting for covariates, a significant risk of hypertension was still possible (OR = 1.71, 95% CI:1.33–2.20). Sex- and age-stratified analyses showed that the association between abdominal obesity and high hs-CRP levels in combination with incident hypertension was more likely to be observed in participants under 60 years of age (OR = 1.72, 95% CI:1.15–2.59) and in women (OR = 1.72, 95% CI:1.15–2.59). Conclusions The findings suggest that elevated hs-CRP levels in combination with abdominal obesity may increase the risk of hypertensive events in the middle-aged and elderly Chinese population.

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%BF, Rather Than BMI, is Associated with an Increased Risk of Sarcopenia in Hospitalized Postmenopausal Chinese Women with Type 2 Diabetes Mellitus

Lu,

Du,

et al. 2024

DMSO

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Purpose To investigate the relationship between obesity indices and sarcopenia in postmenopausal patients with type 2 diabetes mellitus (T2DM) at different body mass index (BMI) levels. Patients and Methods This retrospective cross-sectional study included 298 hospitalized postmenopausal women diagnosed with T2DM. We collected demographic, biochemical, and anthropometric data on each subject. Body composition was measured using dual-energy X-ray absorptiometry (DXA), and skeletal muscle mass index (SMI) and body fat percentage (%BF) were calculated. According to BMI stratification, the patients were divided into normal group A (18.5 kg/m 2 ≤BMI < 24 kg/m 2 ), overweight group B (24.0 kg/m 2 ≤BMI < 28 kg/m 2 ), and obesity group C (28.0 kg/m 2 ≤BMI < 35 kg/m 2 ). Results From group A to group C, SMI (5.21±0.56 vs 5.48±0.56 vs 6.03±0.69) increased gradually (P < 0.05). Logistic regression analysis indicated that for each 1-unit increase in BMI, the risk of sarcopenia decreased by 63.2% (OR=0.368, 95% CI 0.215–0.629, P=0.000) in group A. Age (OR=1.077, 95% CI 1.015–1.144, P=0.015) and %BF (OR=1.094, 95% CI 1.010–1.186, P=0.028) increased the risk of sarcopenia by 1.077 and 1.094 times, respectively, in group B. While every 1-unit increase in BMI, the risk of sarcopenia decreased by 35% (OR=0.650, 95% CI 0.430–0.983, P=0.041) in group B. %BF (OR=1.459, 95% CI 1.093–1.949, P=0.010) increased the risk factors of sarcopenia by 1.459 times in group C. Conclusion In postmenopausal patients with T2DM, BMI had a protective effect on the occurrence of sarcopenia within a certain range, and with the increase of BMI, the risk of sarcopenia was increasing by increased %BF levels in overweight and obese patients.

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Association of Different Obesity Phenotypes with Sarcopenia in Han Chinese Middle-Aged and Elderly with Type 2 Diabetes Individuals

Cited by 3 publications

References 37 publications

Association between metabolic phenotypes and incident pre-sarcopenia: 3 years follow-up of Tehran Lipid and Glucose Study

Association between metabolic phenotypes and incident pre-sarcopenia: 3 years follow-up of Tehran Lipid and Glucose Study

Relationship between abdominal obesity and C-reactive protein in combination with hypertension in middle-aged and older adults: insights from the CHARLS study

%BF, Rather Than BMI, is Associated with an Increased Risk of Sarcopenia in Hospitalized Postmenopausal Chinese Women with Type 2 Diabetes Mellitus

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