Association of different severity of diabetic retinopathy and hearing loss in type 2 diabetes mellitus

Alizadeh, Yousef; Jalali, Mir Mohammad; Sehati, Asieh

doi:10.1016/j.amjoto.2022.103383

Cited by 7 publications

(7 citation statements)

References 23 publications

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“…This was evident among patients with moderate non-proliferative diabetic retinopathy or more severe retinopathy, who were more likely to experience moderate SNHL or worse. This finding is consistent with the previous research on the relationship between diabetic retinopathy and hearing loss [ 13 , 14 ].…”

Section: Discussionsupporting

confidence: 94%

A Correlational Study of Hearing Loss and Severity of Diabetic Retinopathy Among Jordanian Patients

Al-Abed,

Hakooz,

Teimat

et al. 2023

Cureus

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Background Sensorineural hearing loss (SNHL) is a common complication of diabetes, but the underlying mechanisms and risk factors are not fully understood. This study investigated the relationship between several potential risk factors and SNHL in 118 individuals previously diagnosed with diabetes mellitus type 2 (DM2). Methods We did a cross-sectional analysis of data collected from 118 patients with diabetes mellitus at multiple tertiary hospitals in the Jordanian Royal Medical Services (JRMS). The mean age was 60.57 ± 12.8 years, with 56.8% males. Demographic and clinical data were collected, including age, gender, duration of diabetes, presence and duration of hypertension, diabetic retinopathy (DR) severity, tinnitus, and comprehension inability. In addition, a hearing assessment for SNHL was performed using pure-tone audiometry at 0.5, 1, 2, 4, and 8 kHz frequencies. Goodman and Kruskal’s γ test and cumulative odds ordinal logistic regression were used to analyze the relationship between these factors and hearing assessment results for SNHL. Results Goodman and Kruskal’s γ test showed a statistically significant moderate and positive association between diabetic retinopathy severity and sensorineural hearing loss. Further analysis using logistic regression revealed that retinopathy severity, age, and gender were all significant predictors of hearing loss level in this population. The odds of having a higher level of hearing loss increased by 9.1% for each additional year of age and were higher for males than females. In terms of DR severity, a worsening SNHL had lower odds in individuals with no DR or mild nonproliferative DR compared to those with proliferative DR. Conclusion Our findings have important implications for managing SNHL in individuals with diabetes. They indicate that healthcare providers must closely monitor and manage the risk factors in patients with diabetes. Further research is needed to generalize better the relationship between these risk factors and SNHL, including the potential role of other factors, such as exposure to loud noise or certain medications.

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Section: Discussionsupporting

confidence: 94%

A Correlational Study of Hearing Loss and Severity of Diabetic Retinopathy Among Jordanian Patients

Al-Abed,

Hakooz,

Teimat

et al. 2023

Cureus

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“…The gradual onset and complex manifestation of diabetic hearing loss contribute to the lack of research on it, compounded by the intricate structure and relative inaccessibility of the inner ear ( 19 ). Consistent with hearing loss caused by ototoxicity, noise overstimulation, or aging, hair cells in the cochlea are preferentially affected ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

Apelin‑13 reduces high glucose‑induced mitochondrial dysfunction in cochlear hair cells by inhibiting endoplasmic reticulum stress

Huo,

Gu,

2024

Exp Ther Med

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The complex manifestation of diabetic hearing loss and the relative inaccessibility of the inner ear contribute to the lack of research. The present study aimed to reveal the role of Apelin-13, a critical regulator of lipid metabolism, in diabetes-induced hearing loss. Cochlear hair cells treated with high glucose (HG) were adopted as an in vitro research model, and the impacts of Apelin-13 on cellular oxidative stress, apoptosis, mitochondrial dysfunction and endoplasmic reticulum (ER) stress were determined. In addition, cells were treated with the ER stress agonist tunicamycin to further explore its potential role in the regulatory effects of Apelin-13. Apelin-13 inhibited oxidative stress and apoptosis in the HG-induced cells. Additionally, Apelin-13 elevated mitochondrial membrane potential and ATP production, whereas it reduced mitochondrial reactive oxygen species levels. The levels of ER stress-related proteins exhibited a downward trend in response to Apelin-13. By contrast, tunicamycin reversed the effects of Apelin-13 on the aforementioned aspects, suggesting the role of ER stress in the regulatory effects of Apelin-13. In conclusion, the present study elucidated the protective role of Apelin-13 in ameliorating HG-induced mitochondrial functional impairment in cochlear hair cells by inhibiting ER stress.

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“…The incidence of hearing loss at high frequency was 1.17 times higher in the severe retinopathy group (71.4%) than in the mild-to-moderate retinopathy group (61.0%). At the frequency of speech, the ratio of the incidence of DRHL in the two groups was close to three times (31.4% vs. 11.4%) (Alizadeh et al 2022 ). In addition, Ooley et al ( 2017 ).…”

Section: Risk Factors For Drhlmentioning

confidence: 93%

Diabetes mellitus and hearing loss

Deng,

Chen,

2023

Mol Med

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Diabetes mellitus (DM) is a major disease threatening human health and its incidence is increasing year on year. As a chronic complication of DM, hearing loss mostly occurs undetectably. However, the mechanism of this diabetes-related hearing loss (DRHL) remains unclear and there is no effective clinical treatment. Studies of animal or human pathology show that DM causes damage to the blood vessels, spiral ganglion neurons, afferent nerve fibers, the organ of Corti, and the stria vascularis of the inner ear. In recent years, more advances in pathological research have revealed the possible mechanism of DRHL. In addition, a large number of clinical studies suggest that the duration and severity of DM are closely related to the incidence and severity of DRHL. This review focuses on the relationship between DM and hearing loss. The clinical audiological characteristics of diabetic patients, risk factors for DRHL, typical pathology, and potential interventions of DRHL are summarized. This will help reveal the pathogenesis and intervention approaches for DRHL.

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Association of different severity of diabetic retinopathy and hearing loss in type 2 diabetes mellitus

Cited by 7 publications

References 23 publications

A Correlational Study of Hearing Loss and Severity of Diabetic Retinopathy Among Jordanian Patients

A Correlational Study of Hearing Loss and Severity of Diabetic Retinopathy Among Jordanian Patients

Apelin‑13 reduces high glucose‑induced mitochondrial dysfunction in cochlear hair cells by inhibiting endoplasmic reticulum stress

Diabetes mellitus and hearing loss

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