Association of diffuse idiopathic skeletal hyperostosis (DISH) and calcification and ossification of the posterior longitudinal ligament

Resnick, Donald; Guerra, José Luiz; Robinson, C. Andrew; Vint, V

doi:10.2214/ajr.131.6.1049

Cited by 227 publications

(85 citation statements)

References 14 publications

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“…602475) (8), suggesting that they share common etiopathogenic factors. OPLL is mostly found in Asian populations, in particular among the Japanese, where it has been reported to have a prevalence of 1.9-4.3% (9).…”

mentioning

confidence: 99%

“…Since then, many reports of familial aggregation have been reported in different ethnic groups, most of them showing an autosomal-dominant inheritance (17)(18)(19)(20)(21)(22)(23). In contrast, very few cases of familial DISH have been reported (24)(25)(26)(27), and to our knowledge, there is only one description of DISH in association with calcium pyrophosphate dihydrate (CPPD) crystals (8).…”

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confidence: 99%

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Ectopic calcification among families in the Azores: Clinical and radiologic manifestations in families with diffuse idiopathic skeletal hyperostosis and chondrocalcinosis

Bruges-Armas¹,

Couto²,

Timms³

et al. 2006

Arthritis & Rheumatism

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Objective. Twelve families that were multiply affected with diffuse idiopathic skeletal hyperostosis (DISH) and/or chondrocalcinosis, were identified on the island of Terceira, The Azores, potentially supporting the hypothesis that the 2 disorders share common etiopathogenic factors. The present study was undertaken to investigate this hypothesis.Methods. One hundred three individuals from 12 unrelated families were assessed. Probands were identified from patients attending the Rheumatic Diseases Clinic, Hospital de Santo Espírito, in The Azores. Family members were assessed by rheumatologists and radiologists. Radiographs of all family members were obtained, including radiographs of the dorsolumbar spine, pelvis, knees, elbows, and wrists, and all cases were screened for known features of chondrocalcinosis.Results. Ectopic calcifications were identified in 70 patients. The most frequent symptoms or findings were as follows: axial pain, elbow, knee and metacarpophalangeal (MCP) joint pain, swelling, and/or deformity, and radiographic enthesopathic changes. Elbow and MCP joint periarticular calcifications were observed in 35 and 5 patients, respectively, and chondrocalcinosis was identified in 12 patients. Fifteen patients had sacroiliac disease (ankylosis or sclerosis) on computed tomography scans. Fifty-two patients could be classified as having definite (17%), probable (26%), or possible (31%) DISH. Concomitant DISH and chondrocalcinosis was diagnosed in 12 patients. Pyrophosphate crystals were identified from knee effusions in 13 patients. The pattern of disease transmission was compatible with an autosomal-dominant monogenic disease. The mean age at which symptoms developed was 38 years.Conclusion. These families may represent a familial type of pyrophosphate arthropathy with a phenotype that includes peripheral and axial enthesopathic calcifications. The concurrence of DISH and chondrocalcinosis suggests a shared pathogenic mechanism in the 2 conditions.

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confidence: 99%

mentioning

confidence: 99%

Ectopic calcification among families in the Azores: Clinical and radiologic manifestations in families with diffuse idiopathic skeletal hyperostosis and chondrocalcinosis

Bruges-Armas¹,

Couto²,

Timms³

et al. 2006

Arthritis & Rheumatism

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“…The association of DISH with OPLL is as high as 40% to 50% in some series. 3,4 The spinal cord injury occurred in this case after minor trauma and the neurological de®cit consisted of the upper limbs being weaker than the lower limbs which is characteristic of the central cord syndrome. Currently, this syndrome is considered to be due to injury to the corticospinal tracts, which are now known to play the major role of innervating the distal limb musculature, especially of the upper limbs.…”

Section: First Opinionmentioning

confidence: 86%

Surgical management of incomplete cervical cord injury with stenosis secondary to ossification of the posterior longitudinal ligament

Chin

et al. 2000

Spinal Cord

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“…Several previous reports discussed the association of DISH, OPLL, and OLF [23][24][25][26]. Resnick et al [25] described 4 patients with co-existing DISH and cervical OPLL, and they found OPLL in 50% of 74 additional patients with DISH after reviewing their cervical spine radiographs.…”

Section: Associations Of Dish Opll and Olfmentioning

confidence: 99%

“…Resnick et al [25] described 4 patients with co-existing DISH and cervical OPLL, and they found OPLL in 50% of 74 additional patients with DISH after reviewing their cervical spine radiographs. Ehara et al [24] found that DISH was present in 27 out of 109 cases of OPLL (25%) and in 4 out of 18 cases of OLF (21%), and 3 out of 18 patients with OLF had OPLL (16%).…”

Section: Associations Of Dish Opll and Olfmentioning

confidence: 99%

Simultaneous ossification of the posterior longitudinal ligament and ossification of the ligamentum flavum causing upper thoracic myelopathy in DISH: case report and literature review

Guo

Yang

et al. 2010

Eur Spine J

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A rare case of a 44-year-old Chinese male with diffuse idiopathic skeletal hyperostosis (DISH) and simultaneous ossification of the posterior longitudinal ligament (OPLL) and ossification of the ligamentum flavum (OLF) at T1-2 causing thoracic myelopathy is reported herein. Posterior decompression without extirpating the OPLL was performed at T1-2. Postoperatively, symptoms were greatly improved, with remaining hyperreflexia and Grade 4/5 muscle strength in the lower extremities. The Japanese Orthopedic Association score improved from 5 preoperatively to 9 at final follow-up. The presence of a cyst due to leakage of cerebrospinal fluid was confirmed by MRI at day 27, but it resolved after conservative management. The clinical manifestation of DISH, the relationship among DISH, OPLL, and OLF, and management of thoracic myelopathy due to OPLL and OLF were reviewed.Keywords Diffuse idiopathic skeletal hyperostosis Á Ossification of the posterior longitudinal ligament Á Ossification of the ligamentum flavum Á Upper thoracic Á Myelopathy

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Association of diffuse idiopathic skeletal hyperostosis (DISH) and calcification and ossification of the posterior longitudinal ligament

Cited by 227 publications

References 14 publications

Ectopic calcification among families in the Azores: Clinical and radiologic manifestations in families with diffuse idiopathic skeletal hyperostosis and chondrocalcinosis

Ectopic calcification among families in the Azores: Clinical and radiologic manifestations in families with diffuse idiopathic skeletal hyperostosis and chondrocalcinosis

Surgical management of incomplete cervical cord injury with stenosis secondary to ossification of the posterior longitudinal ligament

Simultaneous ossification of the posterior longitudinal ligament and ossification of the ligamentum flavum causing upper thoracic myelopathy in DISH: case report and literature review

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