Association of dilated retinal arteriolar caliber with early age-related macular degeneration: the Handan Eye Study

Ke, Yang; Zhan, Si Yan; Liang, Yuan Bo; Duan, Xianbao; Wang, Fenghua; Wong, Tien Yin; Sun, Lan; Wang, Ningli

doi:10.1007/s00417-011-1824-4

Cited by 30 publications

(30 citation statements)

References 29 publications

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“…Although some studies found no association between retinal arteriolar diameter and choroidal neovascular activity, subretinal fluid, or CMT [33][34][35][36] , the Handan Eye Study [37] reported a relationship between dilated retinal arteriolar caliber and early AMD. Nevertheless, we did not confirm this possibility clinically in noninjected eyes during the study period.…”

Section: Discussionmentioning

confidence: 99%

Comparative Retinal Vessel Size Study of Intravitreal Ranibizumab and Bevacizumab in Eyes with Neovascular Age-Related Macular Degeneration

et al. 2017

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Purpose: The aim of this paper was to assess and compare the effects of intravitreal ranibizumab and bevacizumab on retinal vessel diameter in eyes with neovascular age-related macular degeneration (AMD). Methods: Patients with neovascular AMD who underwent intravitreal injection of either ranibizumab or bevacizumab were included. Noninjected fellow eyes served as a control. The main outcome measures were central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), and the artery-vein ratio (AVR). Results: In the ranibizumab group, the mean CRAE value decreased significantly at 1 week and 1 month (p = 0.002). The AVR value decreased significantly at 1 month (p = 0.028). CRVE values did not change at 1 week and 1 month (p = 0.083). In the bevacizumab group, the preinjection CRAE, CRVE, and AVR values did not change through the study period (p = 0.128, p = 0.600, and p = 0.734, respectively). Conclusion: These results suggest that intravitreal ranibizumab led to significant retinal arteriolar vasoconstriction in eyes with neovascular AMD.

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Section: Discussionmentioning

confidence: 99%

Comparative Retinal Vessel Size Study of Intravitreal Ranibizumab and Bevacizumab in Eyes with Neovascular Age-Related Macular Degeneration

et al. 2017

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“…Thus far, several studies have also examined the association between retinal vascular caliber and age-related macular degeneration (AMD) [114,115,116]. The results from these studies have been inconsistent.…”

Section: Retinal Vascular Caliber and Ocular Diseasesmentioning

confidence: 99%

“…Data from the Singapore Malay Eye Study revealed that wider venular caliber was independently associated with early AMD, whereas no relationship was found between retinal arteriolar caliber and AMD [114]. The Handan Eye Study showed that wider retinal arteriolar caliber was related to early AMD and venular caliber was not related to AMD [115]. In contrast to both these studies, cross-sectional data from the Beaver Dam Eye Study showed no association between retinal vascular calibers and AMD [116].…”

Section: Retinal Vascular Caliber and Ocular Diseasesmentioning

confidence: 99%

Retinal Vascular Caliber Measurements: Clinical Significance, Current Knowledge and Future Perspectives

Ikram¹,

Ong

Cheung³

et al. 2012

Ophthalmologica

191

187

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The retinal vasculature provides a unique window to assess vascular health noninvasively and directly in vivo. Advances in fundus photography and retinal image analysis techniques have enabled the objective and accurate assessment of quantitative retinal vascular caliber measurement. Over the last decade, large population-based studies have shown that retinal vascular calibers are associated with a wide range of subclinical (e.g. atherosclerosis, inflammation and endothelial dysfunction) and clinical cardiovascular diseases (hypertension, diabetes mellitus, stroke, kidney and heart diseases). However, while retinal image analysis provided exciting possibilities to study the pathogenesis of these diseases, its direct applicability in a clinical setting as a ‘test' to predict cardiovascular diseases is yet to be established, particularly within the context of being used as a population screening tool. Nevertheless, with continual development of retinal imaging techniques and newer understanding of the clinical significance of these retinal changes, there remains scope for the development of retinal vascular caliber measurements as a biomarker for vascular disease risk assessment in targeted areas and patient subgroups (e.g. patients with diabetes, suspected hypertension and stroke).

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“…11 To date, several population-based studies have examined the relationship between retinal vascular caliber and AMD in Caucasian populations, [12][13][14] and some Asian, including Chinese and Malay, populations. [15][16][17] With respect to Caucasian studies, longitudinal data from the Beaver Dam Eye Study and the Blue Mountains Eye Study found no association between retinal vascular caliber and AMD. 12,14 In contrast, the Rotterdam Study found a borderline association between smaller arteriolar caliber and AMD in persons older than 75 years.…”

Section: Introductionmentioning

confidence: 97%

Retinal Vascular Caliber and Age-related Macular Degeneration in an Indian Population from Singapore

Chin

Wong

Cheung

et al. 2014

Ophthalmic Epidemiology

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Association of dilated retinal arteriolar caliber with early age-related macular degeneration: the Handan Eye Study

Cited by 30 publications

References 29 publications

Comparative Retinal Vessel Size Study of Intravitreal Ranibizumab and Bevacizumab in Eyes with Neovascular Age-Related Macular Degeneration

Comparative Retinal Vessel Size Study of Intravitreal Ranibizumab and Bevacizumab in Eyes with Neovascular Age-Related Macular Degeneration

Retinal Vascular Caliber Measurements: Clinical Significance, Current Knowledge and Future Perspectives

Retinal Vascular Caliber and Age-related Macular Degeneration in an Indian Population from Singapore

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