2023
DOI: 10.3389/fmed.2023.1286510
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Association of direct bilirubin to total bilirubin ratio with 90-day mortality in patients with acute-on-chronic liver failure

Yuanji Ma,
Lingyao Du,
Shaoqun Zhou
et al.

Abstract: BackgroundHyperbilirubinemia occurs when the liver fails to process bilirubin properly. A disproportionate increase in direct bilirubin indicates a decreased ability of the hepatocytes to uptake and/or convert bilirubin, which may impact the prognosis of patients with acute-on-chronic liver failure (ACLF). However, the association of direct bilirubin to total bilirubin ratio (DB/TB) with outcomes in patients with ACLF remains unclear.MethodsA retrospective study was conducted in West China Hospital of Sichuan … Show more

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Cited by 4 publications
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“…Liver is a vital organ which performs important physiological functions such as metabolism of carbohydrates, lipids, and proteins, detoxification of bilirubin, ammonia and xenobiotics, and synthesis of bile acids and blood coagulation factors ( 26 , 27 ). When the liver function is damaged, the decrease in the amount as well as the function of coagulation factors will result in a variety of coagulation dysfunction, and the PT-INR will be prolonged correspondingly ( 28 , 29 ).…”
Section: Discussionmentioning
confidence: 99%
“…Liver is a vital organ which performs important physiological functions such as metabolism of carbohydrates, lipids, and proteins, detoxification of bilirubin, ammonia and xenobiotics, and synthesis of bile acids and blood coagulation factors ( 26 , 27 ). When the liver function is damaged, the decrease in the amount as well as the function of coagulation factors will result in a variety of coagulation dysfunction, and the PT-INR will be prolonged correspondingly ( 28 , 29 ).…”
Section: Discussionmentioning
confidence: 99%