Association of DISC1 and TSNAX genes and affective disorders in the depression case–control (DeCC) and bipolar affective case–control (BACCS) studies

Schosser, Alexandra; Gaysina, Darya; Cohen‐Woods, Sarah; Chow, Philip C.; Martucci, Livia; Craddock, Nicholas; Farmer, Anne; Korszun, Ania; Gunasinghe, Cerisse; Gray, Joanna; Jones, L. A.; Tozzi, Federica; Perry, Julia; Muglia, Pierandrea; Owen, Michael John; Craig, Ian W.; McGuffin, Peter

doi:10.1038/mp.2009.21

Cited by 61 publications

(31 citation statements)

References 27 publications

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“…Also, rs766288 was the almost same MAFs in both Japanese and Caucasians. Schosser et al (2009) reported that rs766288 was not associated with BP or MDD in the UK population. Although they selected only one SNP (rs766288) in TSNAX, their study was a case-control study using larger samples than our study (Schosser et al 2009).…”

Section: Discussionmentioning

confidence: 96%

“…Schosser et al (2009) reported that rs766288 was not associated with BP or MDD in the UK population. Although they selected only one SNP (rs766288) in TSNAX, their study was a case-control study using larger samples than our study (Schosser et al 2009). Hennah et al haplotype transmission analysis showed that SNPs in intron 4 in TSNAX (rs1615344, rs1615409, and rs766288) was associated with schizophrenia.…”

Section: Discussionmentioning

confidence: 96%

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Translin-Associated Factor X Gene (TSNAX) may be Associated with Female major Depressive Disorder in the Japanese Population

et al. 2009

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Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depressive disorder (MDD). TSNAX is located immediately upstream of DISC1, and has been shown to undergo intergenic splicing with DISC1. It thus may also be influenced by translocation. To our knowledge, there are no reported gene-based association analyses between TSNAX and mood disorders in the Japanese population. We conducted a case-control study of Japanese samples (158 bipolar patients, 314 major depressive disorder patients, and 811 controls) with three tagging SNPs in TSNAX, selected using HapMap database. In addition, we performed an association analysis between TSNAX and the efficacy of fluvoxamine treatment in 120 Japanese patients with MDD. The MDD patients in this study had scores of 12 or higher on the 17 items of the Structured Interview Guide for Hamilton Rating Scale for Depression (SIGH-D). We defined a clinical response as a decrease of more than 50% in baseline SIGH-D within 8 weeks, and clinical remission as an SIGH-D score of less than 7 at 8 weeks. We found an association between rs766288 in TSNAX and female MDD in the allele/genotype analysis. However, we did not find any association between TSNAX and BP or the fluvoxamine therapeutic response in MDD in the allele/genotype analysis or haplotype analysis. Our results suggest that rs766288 in TSNAX may play a role in the pathophysiology of female MDD in the Japanese population. A replication study using larger samples may be required for conclusive results, since our sample size was small.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 96%

Translin-Associated Factor X Gene (TSNAX) may be Associated with Female major Depressive Disorder in the Japanese Population

et al. 2009

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“…Genotyping of the DeCC sample was performed using SNPlexÔ Genotyping System (PE Applied Biosystems, Foster City, CA) as described previously [Schosser et al, 2010]. One SNP, rs1394015 in ZNF80 could not be typed using SNPlexÔ and was genotyped using a Taqman Ò SNP genotyping platform (PE Applied Biosystems).…”

Section: Genotypingmentioning

confidence: 99%

A follow‐up case–control association study of tractable (druggable) genes in recurrent major depression

Schosser¹,

Gaysina²,

Cohen‐Woods³

et al. 2011

American J of Med Genetics Pt B

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The High-Throughput Disease-specific target Identification Program (HiTDIP) aimed to study case-control association samples for 18 common diseases. Here we present the results of a follow-up case-control association study of HiTDIP in major depressive disorder (MDD). The HiTDIP in MDD was conducted in a sample of 974 cases of recurrent MDD of white German origin collected at the Max-Planck Institute (MP-GSK) and 968 ethnically matched controls screened for lifetime absence of depression. Six genes were identified as of interest for a follow-up, based on the strength of the association and based on the interest as potential candidate target for developing new treatment for depression: Solute Carrier Family 4 Member 10 (SLC4A10), Dipeptidyl Peptidase IV (DPP4), Dopamine Receptor D3 (DRD3), Zinc Finger Protein 80 (ZNF80), Nitric Oxide Synthase 2A (NOS2A) and Peroxisome Proliferator-Activated Receptor-Gamma, Coactivator 1, Alpha (PPARGC1A). Within the current study, we attempted to follow-up these findings in a sample from the UK, the Depression Case Control (DeCC) sample consisting of 1,196 cases and 842 screened controls, phenotyped using exactly the same methods as the MP-GSK sample. Performing Cochran-Mantel-Haenzel statistics to test for genotypic and/or allelic differences between the DeCC and MP-GSK samples, we found no significant differences, thus being able to combine the two samples for association testing. In the combined sample of 2,170 MDD cases and 1,810 controls, there were positive findings in the Nitric Oxide Synthase 2A (NOS2A) gene both using single SNP analysis and haplotype analysis.

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“…The DeCC (Depression Case Control) sample consists of cases of recurrent depression fulfi lling DSM-IV and/or ICD-10 criteria of at least moderate severity ascertained from three UK clinical sites (London, Cardiff and Birmingham) (Schosser et al 2010). Subjects were identifi ed from psychiatric clinics, hospitals, general medical practices, and from volunteers responding to media advertisements.…”

Section: Samplesmentioning

confidence: 99%

Genome-wide association study of co-occurring anxiety in major depression

Schosser

Butler

Uher

et al. 2013

The World Journal of Biological Psychiatry

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Objectives . Co-morbidity between depression and anxiety disorders is common. In this study we defi ne a quantitative measure of anxiety by summating four anxiety items from the SCAN interview in a large collection of major depression (MDD) cases to identify genes contributing to this complex phenotype. Methods . A total of 1522 MDD cases dichotomised according to those with at least one anxiety item scored ( n ϭ 1080) and those without anxiety ( n ϭ 442) were analysed, and also compared to 1588 healthy controls at a genome-wide level, to identify genes that may contribute to anxiety in MDD. Results . For the quantitative trait, suggestive evidence of association was detected for two SNPs, and for the dichotomous anxiety present/absent ratings for three SNPs at genome-wide level. In the genome-wide analysis of MDD cases with co-morbid anxiety and healthy controls, two SNPs attained P values of Ͻ 5 ϫ 10 Ϫ 6 . Analysing candidate genes, P values Յ 0.0005 were found with three SNPs for the quantitative trait and three SNPs for the dichotomous trait.Conclusions . This study provides an initial genome-wide assessment of possible genetic contribution to anxiety in MDD. Although suggestive evidence of association was found for several SNPs, our fi ndings suggest that there are no common variants strongly associated with anxious depression.

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Association of DISC1 and TSNAX genes and affective disorders in the depression case–control (DeCC) and bipolar affective case–control (BACCS) studies

Cited by 61 publications

References 27 publications

Translin-Associated Factor X Gene (TSNAX) may be Associated with Female major Depressive Disorder in the Japanese Population

Translin-Associated Factor X Gene (TSNAX) may be Associated with Female major Depressive Disorder in the Japanese Population

A follow‐up case–control association study of tractable (druggable) genes in recurrent major depression

Genome-wide association study of co-occurring anxiety in major depression

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