2020
DOI: 10.1042/ns20200006
|View full text |Cite
|
Sign up to set email alerts
|

Association of distinct type 1 bone morphogenetic protein receptors with different molecular pathways and survival outcomes in neuroblastoma

Abstract: Neuroblastoma (NB) is a paediatric cancer that arises in the sympathetic nervous system. Patients with stage 4 tumours have poor outcomes and 20% of high-risk cases have MYCN amplification. The bone morphogenetic proteins (BMPs) play roles in sympathetic neuritogenesis, by signalling through bone morphogenetic protein receptor (BMPR)2 and either BMPR1A or BMPR1B. Alterations in BMPR2 expression have been reported in NB; it is unknown if the expression of BMPR1A or BMPR1B is altered. We report lower BMPR2 and B… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
3
0

Year Published

2021
2021
2022
2022

Publication Types

Select...
3
1

Relationship

1
3

Authors

Journals

citations
Cited by 4 publications
(3 citation statements)
references
References 48 publications
0
3
0
Order By: Relevance
“…Finally, we hope this editorial will encourage you to read some of the excellent work being published in Neuronal Signaling [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. Of course, we would welcome any pre-submission queries and look forward to receiving your manuscripts in the future.…”
mentioning
confidence: 90%
“…Finally, we hope this editorial will encourage you to read some of the excellent work being published in Neuronal Signaling [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. Of course, we would welcome any pre-submission queries and look forward to receiving your manuscripts in the future.…”
mentioning
confidence: 90%
“…Our results also implicate several genes in cancer development for the first time. We identify that growth/differentiation factor 5 ( GDF5 ) is deficient in NMD- PTC+ variants, as would be expected of a tumor suppressor for the gain-of-function mechanism of NMD- PTC+ variants; however in this case the absolute number of PTC+ variants is small, and the role of GDF5 in tumorigenesis is not well established 12-14 . Many of the remaining genes in Table 1 have recurrent NMD- PTC+ variants that could produce activated and truncated peptides.…”
mentioning
confidence: 91%
“…The protein encoded by BMPR1B gene contains four conserved residues, which can play different roles in defining BMP2, 6, 7 and GDF5 ligand affinity [ 5 ]. The variation and expression change of the BMPR1B have been related to the human ovarian insufficiency and defects of folliculogenesis [ 6 , 7 ], Pierre Robin sequence [ 8 ], isolated acromesomelic dysplasia [ 9 ], neuroblastoma [ 10 ], growth plate defects [ 11 ] and cancers [ 2 ].…”
Section: Introductionmentioning
confidence: 99%