2018
DOI: 10.1016/j.ijcard.2017.09.193
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Association of diuretic treatment at hospital discharge in patients with heart failure with all-cause short- and long-term mortality: A propensity score-matched analysis from SwedeHF

Abstract: Diuretic treatment at hospital discharge was not associated with short-term mortality whereas it was associated with increased long-term mortality. Although we accounted for a wide range of clinical features, measured or unmeasured factors could still explain this increase in risk. However, our results suggest that diuretic treatment at hospital discharge may be regarded as a marker of increased long-term mortality.

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Cited by 10 publications
(6 citation statements)
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“…Correspondingly, only loop diuretics were associated with an elevated risk during all calendar periods. Here, we speculate on a reverse causality: The most severe cases of DCM, requiring diuretic therapy, are also prone to worse outcome, which is compatible with previous findings in HF [ 28 30 ]. Likewise, the most severely symptomatic patients, in functional class NYHA IV, carried a comparatively higher risk with time.…”
Section: Discussionsupporting
confidence: 89%
“…Correspondingly, only loop diuretics were associated with an elevated risk during all calendar periods. Here, we speculate on a reverse causality: The most severe cases of DCM, requiring diuretic therapy, are also prone to worse outcome, which is compatible with previous findings in HF [ 28 30 ]. Likewise, the most severely symptomatic patients, in functional class NYHA IV, carried a comparatively higher risk with time.…”
Section: Discussionsupporting
confidence: 89%
“…Furthermore, a selection bias may exist as participation in the registry is voluntary. Nonetheless, baseline characteristics of patients in the registry are similar to contemporary HF registry data [44], suggesting that patients enrolled in SwedeHF are representative of European real-life patients with HF. Moreover, our study population was enrolled over a 16-year time period characterized by significant changes in the diagnosis and management of HF.…”
Section: Limitationsmentioning
confidence: 65%
“…Previous clinical trial suggested loop diuretics treatment was associated with significant increased long-term mortality at discharge among patients with worsening HF [13]. In a Swedish nationwide trial of 26,218 patients with HF, use of diuretic at discharge was associated with increased long-term all-cause mortality [14]. In this study, 41 patients (59.4%) in the conservative group received diuretics treatment at hospital discharge whereas 33 patients (27.3%) in the invasive group.…”
Section: Discussionmentioning
confidence: 95%