Association of Diverse Genotypes and Phenotypes of Immune Cells and Immunoglobulins With the Course of HIV-1 Infection

Li, Liuzhe; Liu, Yan; Gorny, Miroslaw K.

doi:10.3389/fimmu.2018.02735

Cited by 4 publications

(4 citation statements)

References 161 publications

(198 reference statements)

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“…We also found higher IgG1 in cases compared to controls. HIV-specific IgG1 have been associated with viral control and slower progression to HIV infection 34 , 35 . These data suggest that in the cases, at the pre-HIV infection stage, sexual exposure to HIV or other pathogens may have elicited increased mucosal IgG1 and IgM titres.…”

Section: Discussionmentioning

confidence: 99%

Higher mucosal antibody concentrations in women with genital tract inflammation

Sobia

Pillay

Liebenberg

et al. 2021

Sci Rep

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Inflammatory cytokines augment humoral responses by stimulating antibody production and inducing class-switching. In women, genital inflammation (GI) significantly modifies HIV risk. However, the impact of GI on mucosal antibodies remains undefined. We investigated the impact of GI, pre-HIV infection, on antibody isotypes and IgG subclasses in the female genital tract. Immunoglobulin (Ig) isotypes, IgG subclasses and 48 cytokines were measured prior to HIV infection in cervicovaginal lavages (CVL) from 66 HIV seroconverters (cases) and 66 matched HIV-uninfected women (controls) enrolled in the CAPRISA 004 and 008 1% tenofovir gel trials. Pre-HIV infection, cases had significantly higher genital IgM (4.13; IQR, 4.04–4.19) compared to controls (4.06; IQR, 3.90–4.20; p = 0.042). More than one-quarter of cases (27%) had GI compared to just over one-tenth (12%) in controls. Significantly higher IgG1, IgG3, IgG4 and IgM (all p < 0.05) were found in women stratified for GI compared to women without. Adjusted linear mixed models showed several pro-inflammatory, chemotactic, growth factors, and adaptive cytokines significantly correlated with higher titers of IgM, IgA and IgG subclasses (p < 0.05). The strong and significant positive correlations between mucosal antibodies and markers of GI suggest that GI may impact mucosal antibody profiles. These findings require further investigation to establish a plausible biological link between the local inflammatory milieu and its consequence on these genital antibodies.

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Section: Discussionmentioning

confidence: 99%

Higher mucosal antibody concentrations in women with genital tract inflammation

Sobia

Pillay

Liebenberg

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…We also found higher IgG1 in cases compared to controls. HIV-speci c IgG1 have been associated with viral control and slower progression to HIV infection 34,35 . These data suggest that in the cases, at the pre-HIV infection stage, sexual exposure to HIV or other pathogens may have elicited increased mucosal IgG1 and IgM titres.…”

Section: Discussionmentioning

confidence: 99%

Higher Mucosal Antibody Concentrations in Women with Genital Tract Inflammation

Sobia

Pillay

Liebenberg

et al. 2021

Preprint

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Inflammatory cytokines augment humoral responses by stimulating antibody production and inducing class-switching. In women, genital inflammation (GI) significantly modifies HIV risk. However, the impact of GI on mucosal antibodies remains undefined. We investigated the impact of GI, pre-HIV infection, on antibody isotypes and IgG subclasses in the female genital tract. Immunoglobulin (Ig) isotypes, IgG subclasses and 48 cytokines were measured prior to HIV infection in cervicovaginal lavages (CVL) from 66 HIV seroconverters (cases) and 66 matched HIV-uninfected women (controls) enrolled in the CAPRISA 004 and 008 tenofovir gel trials. Pre-HIV infection, cases had significantly higher genital IgM (4.13; IQR, 4.04-4.19) compared to controls (4.06; IQR, 3.90-4.20; p=0.042). More than one-quarter of cases (27%) had GI compared to just over one-tenth (12%) in controls. Significantly higher IgG1, IgG3, IgG4 and IgM (all p<0.05) were found in women stratified for GI compared to women without. Adjusted linear regression analyses showed several pro-inflammatory, chemotactic, growth factors, and adaptive cytokines significantly correlated with higher titers of IgM and IgG subclasses (p<0.05). The strong and significant positive correlations between mucosal antibodies and markers of GI suggest that GI may impact mucosal antibody profiles. These findings require further investigation to establish a plausible biological link between the local inflammatory milieu and its consequence on these genital antibodies.

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“…The key players and complex interplay of genetic factors predisposing to bNAb development are still being investigated, however, predisposition to natural control of HIV-1, evident in elite neutralizers, involves HLA-I alleles that allow for a robust CD8+ T cell response ( 95 ). Inherently, characteristics of the immune system actually restrict the development of bNAbs.…”

Section: Generation Of Bnabsmentioning

confidence: 99%

Employing Broadly Neutralizing Antibodies as a Human Immunodeficiency Virus Prophylactic & Therapeutic Application

Ding

Patel

et al. 2021

Front. Immunol.

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Despite the discovery that the human immunodeficiency virus 1 (HIV-1) is the pathogen of acquired immunodeficiency syndrome (AIDS) in 1983, there is still no effective anti-HIV-1 vaccine. The major obstacle to the development of HIV-1 vaccine is the extreme diversity of viral genome sequences. Nonetheless, a number of broadly neutralizing antibodies (bNAbs) against HIV-1 have been made and identified in this area. Novel strategies based on using these bNAbs as an efficacious preventive and/or therapeutic intervention have been applied in clinical. In this review, we summarize the recent development of bNAbs and its application in HIV-1 acquisition prevention as well as discuss the innovative approaches being used to try to convey protection within individuals at risk and being treated for HIV-1 infection.

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Association of Diverse Genotypes and Phenotypes of Immune Cells and Immunoglobulins With the Course of HIV-1 Infection

Cited by 4 publications

References 161 publications

Higher mucosal antibody concentrations in women with genital tract inflammation

Higher mucosal antibody concentrations in women with genital tract inflammation

Higher Mucosal Antibody Concentrations in Women with Genital Tract Inflammation

Employing Broadly Neutralizing Antibodies as a Human Immunodeficiency Virus Prophylactic & Therapeutic Application

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