Association of DNA repair and xenobiotic pathway gene polymorphisms with genetic susceptibility to gastric cancer patients in West Bengal, India

Ghosh, Sudakshina; Bankura, Biswabandhu; Ml, Saha; Maji, Suvendu; Ghatak, Souvik; Ak, Pattanayak; Sadhukhan, Susanta; Guha, Manalee; Sk, Nachimuthu; Panda, CK; Maity, Biswanath; Das, Madhusudan

doi:10.1007/s13277-015-4780-5

Cited by 23 publications

(23 citation statements)

References 61 publications

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“…47 Contrary to the results of the present study, some previous studies from North India have reported an increased risk with AA genotype of XRCC1p.Arg399Gln polymorphism in lung cancer, 48 head and neck cancer, 49 colorectal cancer 50 and prostate cancer. 51 Similarly, some studies from South India reported an association of increased risk with the AA genotype in gastric cancer, 52 colorectal cancer, 29 lung cancer, 53,54 cervical cancer, 55 Naso-pharyngeal cancer, 56 acute lymphoblastic leukemia 57 and acute myeloid leukemia. 58 However, few studies from South India reported no association of XRCC1p.…”

Section: Discussionmentioning

confidence: 98%

Association of XRCC1, XRCC2 and XRCC3 Gene Polymorphism with Esophageal Cancer Risk

Kaur¹,

Sambyal²,

Guleria³

et al. 2020

CEG

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The X-ray repair cross-complementing (XRCC) gene polymorphisms influence esophageal carcinogenesis by altering the DNA repair capacity. The present study was designed to screen five single nucleotide polymorphisms (SNPs) of XRCC genes for their susceptibility to esophageal cancer (EC) risk. There is no previous report on these polymorphisms for EC from India, where EC frequency is high. Methods: The present study included 497 subjects (213 EC patients and 284 healthy controls). The polymorphisms were screened using the PCR-RFLP method and allele and genotype distribution were compared using chi-square test. Association analysis was done by haplotype analysis and linkage disequilibrium (LD) analysis. Gene-gene interactions were identified using multifactor dimensionality reduction (MDR). The risk was calculated using binary logistic regression. Results: For XRCC1 p.Arg399Gln, a decreased risk for EC was associated with the AA genotype [OR (95% CI): 0.53 (0.3-0.95), p=0.03] even after adjusting for various covariates [OR (95% CI): 0.49 (0.26-0.9), p=0.024] and with the recessive model [OR (95% CI): 0.49 (0.27-0.8), p=0.016]. The GA genotype of p.Arg280His was associated with an increased risk for EC [OR (95% CI): 1.7 (1.0-2.82), p= 0.045] after adjustments. The two XRCC1 polymorphisms, p.Arg399Gln and p.Arg194Trp were in slight LD among EC patients (D ̍́= 0.845, r 2 =0.042). XRCC2 and XRCC3 polymorphisms were not associated with EC risk. Conclusion: XRCC1 p.Arg399Gln plays a protective role in the development of the EC. The study is the first report from India, providing baseline data about genetic polymorphisms in DNA repair genes XRCC1, XRCC2 and XRCC3 modulating overall EC risk.

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Section: Discussionmentioning

confidence: 98%

Association of XRCC1, XRCC2 and XRCC3 Gene Polymorphism with Esophageal Cancer Risk

Kaur¹,

Sambyal²,

Guleria³

et al. 2020

CEG

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“…Moreover, previous studies have reported that many environmental and lifestyle factors could contribute to the risk of developing gastric cancer, such as consumption of preserved food containing carcinogenic nitrates, tobacco smoking, alcohol consumption, and overweight (Alberts et al, 2003). In additional, previous studies have reported that some genetic factors may contribute to the risk of developing gastric cancer, such as miRNA-196a-2, stromelysin-1 promoter gene, DNA repair and xenobiotic pathway gene, TP53 condon 72 gene and cytotoxic T-lymphocyte antigen 4 gene (Krishnaveni et al, 2015;Tang et al, 2015;Zha et al, 2015;Ghosh et al, 2016;Song et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Association between IL-17A and IL-17F gene polymorphisms and risk of gastric cancer in a Chinese population

et al. 2016

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ABSTRACT. We conducted a case-control study to investigate the role of interleukin-17A (IL-17A) rs2275913 G > A and IL-17F rs763780 T > C polymorphisms in the development of gastric cancer. A hospitalbased case-control design was performed, and 153 patients and 207 control subjects were consecutively selected from the Third Affiliated Hospital between May 2013 and December 2014. Polymerase chain reaction-restriction fragment length polymorphism was used to genotype for IL-17A rs2275913 G > A and IL-17F rs763780 T > C. The genotypes of IL-17A rs2275913 G > A and IL-17F rs763780 T > C did not deviate from Hardy-Weinberg equilibrium (P values were 0.44 and 0.11, respectively). By unconditional logistic regression analysis, we observed that the GG genotype of rs2275913 was associated with an increased risk of gastric cancer compared to the AA genotype [odds ratio (OR) = 2.66; 95% confidence interval (CI) = 1.26-5.66]. The AG + GG genotype of rs2275913 increased the susceptibility to gastric cancer compared to the AA genotype, and the adjusted OR (95%CI) was 2.66 (1. 26-5.66). Moreover, the GG genotype of rs2275913 was correlated with an elevated risk of gastric cancer when compared with the AA + AG genotype (OR = 2.15; 95%CI = 1.08-4.34). In conclusion, we found that the IL-17A rs2275913 G > A gene polymorphism was significantly associated with an increased risk of gastric cancer in codominant, dominant, and recessive models.

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“…So far, several studies have reported on the association between XRCC1 polymorphisms and development of several types of cancers, including non-small cell lung cancer, gastric cancer, cervical cancer, hepatocellular carcinoma, pancreatic cancer, ovarian cancer, colorectal cancer, and thyroid cancer (Liu et al, 2012;Abdel-Fatah et al, 2013;Feng et al, 2014;Wang and Ai, 2014;Xia et al, 2014;Cătană et al, 2015;Han et al, 2015;Huang et al, 2015;Xu et al, 2015;Zhao and Chen, 2015;Ghosh et al, 2016). Liu et al (2015) observed a significant relationship between the XRCC1 Arg399Gln polymorphism and risk of cervical cancer in a meta-analysis comprising 2051 cervical cancer patients and 2919 control subjects.…”

Section: Discussionmentioning

confidence: 99%

Association between XRCC1 polymorphisms and laryngeal cancer susceptibility in a Chinese sample population

Zhang

Liao

et al. 2016

Genet. Mol. Res.

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Laryngeal cancer is the major malignant tumor affecting the upper respiratory tract. Previous studies have reported on the association between XRCC1 genetic polymorphisms and risk of laryngeal cancer, but with conflicting results. In this study, we attempted to assess the association between XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphisms and risk of laryngeal cancer in a Chinese population. A total of 126 laryngeal cancer patients and 254 control subjects were recruited to this study from the Second Medical College of Jinan University between December 2013 and May 2015. The XRCC1 Arg194Trp, Arg280His, and Arg399Gln polymorphic sites were genotyped by polymerase chain reaction-restriction fragment length polymorphism. Our results revealed a significant association between the AA genotype of XRCC1 Arg280His [odds ratio (OR) = 2.51, 95% confidence interval (CI) = 1.29-4.87, P = 0.01] and an increased risk of laryngeal cancer susceptibility compared to the GG genotype. Moreover, the A allele showed a higher risk of laryngeal cancer susceptibility compared to the G allele (OR = 1.63, 95%CI = 1.19-2.50, P = 0.002). In conclusion, the results of our study suggest that the AA genotype and A allele of the XRCC1 Arg280His polymorphism are associated with an increased laryngeal cancer risk in a Chinese population.

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Association of DNA repair and xenobiotic pathway gene polymorphisms with genetic susceptibility to gastric cancer patients in West Bengal, India

Cited by 23 publications

References 61 publications

<p>Association of <em>XRCC1</em>, <em>XRCC2</em> and <em>XRCC3</em> Gene Polymorphism with Esophageal Cancer Risk</p>

<p>Association of <em>XRCC1</em>, <em>XRCC2</em> and <em>XRCC3</em> Gene Polymorphism with Esophageal Cancer Risk</p>

Association between IL-17A and IL-17F gene polymorphisms and risk of gastric cancer in a Chinese population

Association between XRCC1 polymorphisms and laryngeal cancer susceptibility in a Chinese sample population

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