Association of drug-induced gingival enlargement (calcium channel blockers) and local factors: Who is the culprit?

Chouksey, Ajay; Awasthi, Nitin; Rai, Jayesh; Chaudhary, Abhishek

doi:10.15713/ins.idmjar.68

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…4 Gingival hyperplasia is characterized by an accumulation of extracellular matrix within the gingival connective tissue particularly the collagenous components. [14][15][16] It has been associated with multiple factors including systemic inflammation, adverse drug effects and cardiovascular disease. Drug-induced gingival overgrowth of an adverse drug reaction of commonly prescribed drugs Calcium Channel Blockers (CCBs).…”

Section: Discussionmentioning

confidence: 99%

Periodontal management of the elderly with medical compromise: a case report

Sembiring¹,

Adam²

2019

J Dentomaxillofac Sci

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Objective: The aim of the periodontal treatment is to provide healthy and functional dentition all through a lifetime. The primary objective of this case report is to describe that periodontal disease in the elderly complicated by medical compromise should be treated and the results will be very satisfactory. Methods: A sixty-eight years old female patient with cardiovascular disease took amlodipine and aspirin medication since two months ago. Patients complained of enlarged gingiva, all of the teeth become mobility. Periodontal surgery was performed after referring back to the internist to prepare patient condition facing periodontal surgery. Results: After several phase of periodontal treatment, the gingival inflamation demonstrated a good control and periodontal status become more stable. Conclusion: Although managing periodontal disease in elderly is complicated, the proper control of the periodontal infection and inclusion of other healthcare professionals will improve the prognosis and get a satisfactory result. In fact, studies demonstrate that elderly individuals whose comprehensive management includes dental care develop fewer co-morbid conditions and require less expenditure of healthcare rupiahs.

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Section: Discussionmentioning

confidence: 99%

Periodontal management of the elderly with medical compromise: a case report

Sembiring¹,

Adam²

2019

J Dentomaxillofac Sci

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“…Gingival overgrowth (GO) or enlargement is an increase in the size of the gingiva as a result of the collagenous components of the extracellular matrix that accumulate within the gingival connective tissue [1]. It may be idiopathic or be associated with a variety of factors like congenital diseases, hormonal disturbances, long-term poor oral hygiene, inflammation, neoplastic conditions, and adverse drug reactions.…”

Section: Introductionmentioning

confidence: 99%

“…It may be idiopathic or be associated with a variety of factors like congenital diseases, hormonal disturbances, long-term poor oral hygiene, inflammation, neoplastic conditions, and adverse drug reactions. 1 Some of the medications currently associated with gingival enlargement are anticonvulsants (phenytoin), antihypertensive drugs like calcium channel blockers (nifedipine and amlodipine) and immunosuppressive agents (cyclosporin A and tacrolimus) [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Gingival overgrowth and associated factors in a population of Nigerian hypertensives

Omotunde¹,

Ekua²

2021

World J. Adv. Res. Rev.

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Background: Gingival overgrowth may be idiopathic or secondary. Drug Induced Gingival Overgrowth (DIGO) occurs within 3 months of treatment and is more prevalent in younger age group with predilection for the anterior gingival tissue and usually not associated with attachment loss or tooth mobility unless there is an existing periodontal disease. Methodology: 170 hypertensive patients were recruited for the study; 85 calcium channel blocker (CCB) and 85 non-CCB users. Interviewer-administered questionnaires was used to obtain socio-demographic information as well as medical and drug history. GO was assessed using New Clinical Index for DIGO and data was analyzed with SPSS version 21 (Armonk, NY: IBM Corp). Continuous and nominal variables were described with means, standard deviations and frequencies. Statistical significance was set at P < 0.05. Results: Amlodipine was the most commonly used CCB. The prevalence of DIGO in CCB and non-CCB was the same (49.5%). Gingival enlargement was found equally among both sexes in the CCB and non-CCB groups. A third of the participants with GO were 70 years and above while those without were majorly in the fifth and sixth decade of life. Two-third of those with DIGO had fair oral hygiene status, two-fifth had gingival bleeding and three-fifth had mild gingival inflammation. Those without DIGO in both groups had a slight female predominance and majorly good oral hygiene. Associated factors with DIGO were female sex, 60-69 age group, 10mg drug dosage, been on medication less than 10 years, mild gingival inflammation and generalized gingivitis. Conclusion: There was no difference in the prevalence of DIGO between BBC and non-BBC users. However, there was mild gingival inflammation in all participants with DIGO and amlodipine users were three times more at risk of developing DIGO than nifedipine users. Thus, it is imperative to advise the hypertensives on the importance of maintaining adequate oral hygiene measures and incorporate periodontal care in their management so as to ameliorate the side effects of their medication.

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“…Tanda klinis yang muncul yaitu gingiva membesar, halus, mengkilat, konsistensi lunak, warna merah dan pinggirannya tampak membulat. 3 Hal ini menimbulkan masalah estetik yang kurang baik. Berdasarkan etiopatogenesisnya, pembesaran gingiva diklasifikasikan menjadi Inflammatory Enlargement, Drug Induced Enlargment dan Enlargement Associated with Systemic Diseases.…”

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Laporan Kasus: Pembesaran gingiva yang diinduksi fenitoin

Satrio

Laksmi

2018

stoma

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Gingival enlargement is a kind of oral manifestation, that can caused by induction of anticonvulsant drugs. Phenytoin is one of anticonvulsant drug that can caused gingival enlargement. Gingival enlargement in this case developed until grade III. The patient was highly phenytoin dependent and can’t be reconciled. The aim of this paper is to find out the cause of phenytoin induced gingival enlargement and its treatment. A 20 years old woman came to RSGM UNSOED to check her swollen gums. The patient’s history was epilepsy and had been regularly taking phenytoin. The patient was taking 30 mg phenobarbital, 10 mg clobazam, 1 mg folic acid and 100 mg phenytoin 2 times a day with 2 capsules each time that had been consumted for 4 years. Phenytoin as anticonvulsant drug has side effects that can caused gingival enlargement, this is because phenytoin can increase extracellular connective tissue, collagen and fibrous.

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Association of drug-induced gingival enlargement (calcium channel blockers) and local factors: Who is the culprit?

Cited by 4 publications

References 18 publications

Periodontal management of the elderly with medical compromise: a case report

Periodontal management of the elderly with medical compromise: a case report

Gingival overgrowth and associated factors in a population of Nigerian hypertensives

Laporan Kasus: Pembesaran gingiva yang diinduksi fenitoin

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