Association of dry eye disease with psychiatric or neurological disorders in elderly patients

Han, Sang Beom; Yang, Hee Kyung; Hyon, Joon Young; Wee, Won Ryang

doi:10.2147/cia.s137580

Cited by 56 publications

(53 citation statements)

References 89 publications

(186 reference statements)

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“…A sleep disorder is a serious health problem and eye diseases may be linked to sleep in many aspects. 1 There is an increased interest in the psychiatric profile of patients with dry eye disease (DED), 2,3 including depression and sleep disorders, since a neurologic and psychiatric pathophysiology may underlie DED. Since DED 4,5 and sleep disorders 6,7 are more prevalent in women than men, we reviewed sleep and health, eyes and sleep, and DED and sleep in terms of the systemic and eye health, especially of women.…”

mentioning

confidence: 99%

Sleep Disorders are a Prevalent and Serious Comorbidity in Dry Eye

Ayaki

Ohta

Kawashima

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Sleep is an essential life habit and closely associated with lifespan, diabetes, hypertension, and mental health. Sleep disorders are a prominent, but overlooked problem in patients with dry eye disease (DED), characterized by a poor sleep index, short sleep duration, long sleep latency, and poor subjective sleep. DED and sleep disorders are more prevalent in women than men. Moreover, sleep quality in DED is worse than in other eye diseases, including glaucoma, retinal diseases, cataract, and allergic and chronic conjunctivitis. METHODS. We reviewed the literature for studies investigating sleep and health, eyes and sleep, and DED and sleep, in terms of systemic and eye health, especially in women. RESULTS. Two studies reported that approximately half of patients with DED suffer from poor sleep. The severity of mood disorders, including anxiety and depression, is correlated strongly with sleep disorders in DED, and the symptoms and signs of DED, especially pain, also are correlated with sleep quality. Sleep disorders are documented in primary Sjögren's syndrome and an association with sleep apnea and depression is suggested. Primary Sjögren's syndrome includes arthritis and other rheumatic disease causing pain and fatigue; however, how sicca contributes to sleep disorders is not known. CONCLUSIONS. Possible explanations for sleep disorders in DED may be depression, pain, and eye exposure at night. Reciprocal effects may be expected and consultation-liaison psychiatry is recommended for the management of sleep disorders in DED. Topical medication and lid heating also may be advantageous for sleep quality in DED.

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confidence: 99%

Sleep Disorders are a Prevalent and Serious Comorbidity in Dry Eye

Ayaki

Ohta

Kawashima

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…1 Dry Eye Syndrome (DES) or Keratoconjunctivitis Sicca (KCS) is one of the most common ophthalmic disorders associated with symptoms including ocular discomfort, pain, dryness and foreign body sensation, which can impair the quality of life of diabetic patients. 2 Diabetic retinopathy constitutes 4.8% of the global cause for blindness with high prevalence (ranging from 7.3% to 25%) in India. Diabetic retinopathy is a silent disease and calls for early detection and timely intervention for its management is necessary.…”

Section: Introductionmentioning

confidence: 99%

Dry eye syndrome in patients of diabetes with and without diabetic retinopathy

Sharma¹,

Aslami²,

Kumar³

et al. 2018

Int J Res Med Sci

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Background: Diabetes Mellitus (DM) can lead to Diabetic retinopathy. Dry Eye Syndrome is commonly seen in diabetic patients. The purpose of this study was assessment of dry eye in patients with and without diabetic retinopathy.Methods: The study was conducted in the department of Ophthalmology and Rural and Urban centres of Community Medicine, Narayan Medical College and Hospital, Sasaram, Bihar. All cases of Type 2 diabetes mellitus over six months period were considered for the study. The diabetic patients were divided into two groups, one with diabetic retinopathy and others without diabetic retinopathy. All patients were subjected to McMonnie’s questionnaire and clinical evaluation including tear film studies like Schirmer’s test and Tear Film Break Up Time (TBUT).Results: 60 diabetic patients were enrolled for the study, 30 had evidence of diabetic retinopathy while 30 had no evidence. The most common dry eye symptom reported was foreign body sensation (96.7%). All Signs of dry eye disorder were found more commonly in patients with diabetic retinopathy as compared to those without diabetic retinopathy. Mcmonnie’s scores correlates well with both Schirmer’s basic secretion test (BST) and TBUT.Conclusions: Dry eye syndrome must be diagnosed in diabetic patients. Periodic screening of diabetic patients should be carried out to evaluate diabetic retinopathy and its complications.

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“…Despite a long history of recognizing the symptom of the watery eye, there are few reports on its impact on patients daily activities and social life (Cassel 1982, Shin et al 2015. There are few studies that describe the effect of the dry eye on the expression of psychiatric symptoms, but so far there is no influence which has been described on the expression of depressive symptoms in patients with watery eye (HAN SB et al 2017, Zheng Y et al 2017). This has resulted in certain health care policy worldwide, that assigns higher priorities to anterior eye segment problems, namely cataract and its treatment to other ophthalmological conditions and treatments.…”

Section: Introductionmentioning

confidence: 99%

Quality of Life and Depression Level in Patients With Watery Eye

Mandić¹,

Ivkić²,

Mandić³

et al. 2018

Psychiat Danub

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Background: The aim of this study was to assess subjective, human aspect of the medical condition, evaluate the quality of life (QOL) and level of depressive symptoms in patients with watery eye and compare it with patients with two most common causes of visual deterioration: cataract and macular region pathology. The results of this study may serve to raise awareness of watery eye impact on a large number of patients and subsequently promote their treatment in order to restore full visual and life quality necessary for normal human functioning. Subjects and methods: In this prospective, randomised, questionnaire-based study, we have surveyed three groups of patients with a total of 210 patients: group with the watery eye of different etiology (n=69), group with one pseudophakic eye and one cataract eye (n=73) and group with the unilateral pathology of the macular region (n=68). All three groups underwent a complete ophthalmologic examination. To examine the overall quality of life we have used a modified vision-related quality of life questionnaire (VR-QOL) and to evaluate depression level "Beck Depression Inventory-2". The results were analyzed with statistical program STATISTICA 13. Results: Compared to group with unilateral cataract eye and to group with unilateral pathology of the macular region, the results of this study show that patients with watery eye have significantly decreased quality of life in all daily activities, particularly in outdoor activities (F=125.80, df=2/143, p<0.01), during sports (F=36.67, df=2/143, p<0.01) and interpersonal relations (F=18.73, df=2/143, p<0.01). Results between three groups showed that group with watering eye expressed highest depression level and group with one pseudophakic eye and the other cataract eye the lowest (F=25.86, df=2/207, p<0.01). Conclusion: Watery eye has a significant impact on vision-related quality of life. Our research showed that patients with watery eye had expressed more depressive symptoms than other groups, but still without statistically significant value. Since it affects a large and heterogenic group of patients it is important to be recognized on time and treated etiologically in attempt to restore full function and life quality. The results of this study may serve to raise awareness of watery eye impact on a large number of patients and subsequently promote their treatment in order to restore full visual and life quality necessary for normal functioning.

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Association of dry eye disease with psychiatric or neurological disorders in elderly patients

Cited by 56 publications

References 89 publications

Sleep Disorders are a Prevalent and Serious Comorbidity in Dry Eye

Sleep Disorders are a Prevalent and Serious Comorbidity in Dry Eye

Dry eye syndrome in patients of diabetes with and without diabetic retinopathy

Quality of Life and Depression Level in Patients With Watery Eye

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