Association of dry eye disease and sun exposure in geographically diverse adult (≥40 years) populations of India: The SEED (sun exposure, environment and dry eye disease) study - Second report of the ICMR-EYE SEE study group

Tandon, Radhika; Vashist, Praveen; Gupta, Vivek; Sahay, Pranita; Deka, Dipali; Singh, Satyendra; Vishwanath, K; Murthy, G V S

doi:10.1016/j.jtos.2020.07.016

Cited by 28 publications

(43 citation statements)

References 45 publications

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“…1-4),suggesting that the antioxidant approach is useful against corneal epithelial photo-oxidative damage. Previous clinical reports have shown that prolonged use of a VDT 10) and increased exposure to sunlight 6,7) can increase the risk of dry eye symptoms. Oxidative stress and inflammation are thought to play a role in the development of dry eyes, [37][38][39] and it is known that lipid peroxides, 40) which are produced by oxidative stress and proinflammatory proteins such as matrix metalloproteinase (MMP)-9, 41,42) are increased in the tear fluid of dry eye patients.…”

Section: Discussionmentioning

confidence: 97%

“…5) In addition, epidemiological studies have reported that dry eye symptoms are more likely in areas with high sun exposure, suggesting that UVlightmayaffecttheocularsurfacenegatively. 6,7) Basedon these findings, it is important to understand the effects of UV light on corneal epithelial cells and to construct methods to protect the cornea from UV light.…”

Section: Introductionmentioning

confidence: 99%

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Free-Radical Scavenger NSP-116 Protects the Corneal Epithelium against UV-A and Blue LED Light Exposure

Ishida

Yako

Tanaka

et al. 2021

Biological & Pharmaceutical Bulletin

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The corneal epithelium is continuously exposed to oxygen, light, and environmental substances. Excessive exposure to those stresses is thought to be a risk factor for eye diseases. Photokeratitis is damage to the corneal epithelium resulting in a painful eye condition caused by unprotected exposure to UV rays, usually from sunlight, and is often found in people who spend a long time outdoors. In modern life, human eyes are exposed to artificial light from light-emitting diode (LED) displays of computers and smartphones, and it has been shown that short-wavelength (blue) LED light can damage eyes, especially photoreceptors. However, the effect of blue LED light on the cornea is less understood. In addition, it is important to develop new treatments for preserving human eyesight and eye health from light stress. Here, we used human corneal epithelial cells-transformed (HCE-T) cells as an in-vitro model to investigate the protective effect of NSP-116, an imidazolyl aniline derivative, against the oxidative stress induced by light in the corneal epithelium. Treatment with 10 µM NSP-116 significantly increased the cell viability and reduced the death ratio following UV or blue LED light exposure. Furthermore, NSP-116 treatment decreased light-induced reactive oxygen species production and preserved the mitochondrial membrane potential. Immunoblotting data showed that NSP-116 suppressed the stress response pathway. Finally, NSP-116 treatment prevented corneal epithelial apoptosis induced by blue LED light in an in-vivo mouse model. In conclusion, NSP-116 has a protective effect against oxidative stress and corneal cell death from both UV and blue LED light exposure.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Free-Radical Scavenger NSP-116 Protects the Corneal Epithelium against UV-A and Blue LED Light Exposure

Ishida

Yako

Tanaka

et al. 2021

Biological & Pharmaceutical Bulletin

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“…Numerous epidemiological studies have reported age, sex, place of residence, urbanization, occupation, and socio-economic status as significant risk factors for developing DED [ 9 ]. Increased risk of DED has also been associated with prolonged exposure to sunlight, indoor smoke, and smoking [ 11 ]. With growing urbanization and digitization, along with dynamically changing environmental exposures, we can anticipate a greater surge in cases of DED in the coming years.…”

Section: Levels Of Prevention Of Dedmentioning

confidence: 99%

“…The risk of exposure to such occupational hazards can be mitigated by having mandatory protective measures for individuals at high risk for ocular chemical, thermal, or radiation injuries. Environmental pollution and particulate matter exposure have also been associated with DED and can be effectively addressed only when the countermeasures are planned as legislative policies to conserve the environment [ 11 , 27 ].…”

Section: Levels Of Prevention Of Dedmentioning

confidence: 99%

An Evidence-Based Strategic Approach to Prevention and Treatment of Dry Eye Disease, a Modern Global Epidemic

2021

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Dry eye disease (DED) is an emerging health concern causing significant visual, psychological, social, and economic impact globally. In contrast to visual rehabilitation undertaken at late stages of DED, measures instituted to prevent its onset, establishment, or progression can alter its natural course and effectively bring down the associated morbidity. This review attempts to present the available literature on preventive strategies of DED at one place, including strategies for risk assessment and mitigation, targeting a wide range of population. A literature search was conducted using PubMed and an extensive literature review on preventive strategies for DED was compiled to put forth a holistic and strategic approach for preventing DED. This can be undertaken at various stages or severity of DED directed at different tiers of the health care system. Conclusion: This review intends to put emphasis on preventive strategies being adopted as an integral part of routine clinical practice by general ophthalmologists and specialists to tackle the burden of DED and improve the quality of the lives of the patients suffering from it.

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“…The prevalence of dry eye is increasing worldwide 5 – 7 . Common associated factors include age 5 – 14 , female gender 7 , 12 – 15 , extended visual display terminal use 8 , 16 – 20 , sleep disorder 21 , 22 , environmental factors 9 , 12 , 17 , 23 , 24 , seasonality 24 , etc., among which age is the most important and universal 10 .…”

Section: Introductionmentioning

confidence: 99%

Protective effects of low-molecular-weight components of adipose stem cell-derived conditioned medium on dry eye syndrome in mice

Lee

Sun

Zhang

2021

Sci Rep

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The present study demonstrated the protective effects of low-molecular-weight adipose-derived stem cell-conditioned medium (LADSC-CM) in a mouse model of dry eye syndrome. Mice subjected to desiccating stress and benzalkonium chloride had decreased tear secretion, impaired corneal epithelial tight junction with microvilli, and decreased conjunctival goblet cells. Topical application of adipose-derived stem cell-conditioned medium (ADSC-CM) stimulated lacrimal tear secretion, preserved tight junction and microvilli of the corneal epithelium, and increased the density of goblet cells and MUC16 expression in the conjunctiva. The low-molecular-weight fractions (< 10 kDa and < 3 kDa) of ADSC-CM (LADSC-CM) provided better protections than the > 10 kDa or > 3 kDa fractions of ADSC-CM. In the in vitro study, desiccation for 10 min or hyperosmolarity (490 osmols) for 24 h caused decreased viability of human corneal epithelial cells, which were reversed by LADSC-CM. The active ingredients in the LADSC-CM were lipophobic and stable after heating and lyophilization. Our study demonstrated that LADSC-CM had beneficial effects on experimental dry eye. It is worthy of further exploration for the active ingredient(s) and the mechanism.

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Association of dry eye disease and sun exposure in geographically diverse adult (≥40 years) populations of India: The SEED (sun exposure, environment and dry eye disease) study - Second report of the ICMR-EYE SEE study group

Cited by 28 publications

References 45 publications

Free-Radical Scavenger NSP-116 Protects the Corneal Epithelium against UV-A and Blue LED Light Exposure

Free-Radical Scavenger NSP-116 Protects the Corneal Epithelium against UV-A and Blue LED Light Exposure

An Evidence-Based Strategic Approach to Prevention and Treatment of Dry Eye Disease, a Modern Global Epidemic

Protective effects of low-molecular-weight components of adipose stem cell-derived conditioned medium on dry eye syndrome in mice

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