Association of duodenal eosinophilia with Helicobacter pylori-negative functional dyspepsia

Evaluation of the association between duodenal eosinophil counts, functional dyspepsia, symptomatic erosive GERD and other variables: A retrospective multi-ethnic Malaysian study.

“…The failure to nd a relationship between functional dyspepsia and duodenal eosinophilic in ltration irrespective of whether it was measured in terms of absolute counts or rate of pre-de ned eosinophilia, is concordant with the ndings of some studies 8-10 but not with others [3][4][5] . We are cognisant however of a limitation of our retrospective study that restricts the conclusions that can be drawn with regard to the relationship between duodenal eosinophilia and functional dyspepsia.…”

“…In this context, it should be noted that normal ranges for duodenal eosinophil counts among healthy adults have not been clearly established. The cut off value of eosinophils per HPF used to de ne duodenal eosinophilia in previous publications has been variable, ranging from 15 to 63 per HPF 4,6,8,11 . The arbitrary choice of 15 per HPF in our study as proposed by Chaudhari et al, 11 was based on the premise that the degree of eosinophilia in conditions such as functional dyspepsia and GERD is likely to be subtle and a relatively lower cut-off would have greater sensitivity in detecting a positive signal.…”

“…The arbitrary choice of 15 per HPF in our study as proposed by Chaudhari et al, 11 was based on the premise that the degree of eosinophilia in conditions such as functional dyspepsia and GERD is likely to be subtle and a relatively lower cut-off would have greater sensitivity in detecting a positive signal. A number of studies have used a cut-off value of >22 counts per 5 HPF to de ne eosinophilia 3,4,6 . When we reanalysed our data using a cut-off value of > counts per 5 HPF, the association between duodenal eosinophilia and concomitant co-morbidities was preserved but the associations with symptomatic erosive GERD, ethnicity and age were no longer detectable (data not shown).…”

“…3 The association between duodenal eosinophilia and functional dyspepsia however has not been uniformly consistent. Some have reported duodenal eosinophilia to be positively associated with functional dyspepsia as a whole [3][4][5] while others have reported an association with only subtypes of functional dyspepsia [6][7][8][9] or indeed no association at all. 10 The relevance of the association between duodenal eosinophilia and functional dyspepsia lies not only in its importance in elucidating the pathogenesis of functional dyspepsia but also in the potential applicability of duodenal eosinophilia as a diagnostic biomarker of functional dyspepsia.…”

WITHDRAWN: Identification and Genetic Analysis of Major Gene ST3GAL4 Related to Serum Alkaline Phosphatase in Chickens

“…Besides, the results of tissue expression showed that the expression level of GA and AA genotype in duodenum were signi cantly higher than that of GG genotype. Duodenum has important digestive function, studies have found that it plays an important role in functional dyspepsia [31]. This may be due to the low ALP level and poor digestive function of GG genotype in the process of commercial breeding of broilers, which would result in the gradual selection of genotype AA during this process, and thus, genotype AA was more common in broiler population.…”